A5024141858- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Effects of Radiation Exposure
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Chronic Disease Management Strategies
- Sarcoidosis and Beryllium Toxicity Research
- Systemic Sclerosis and Related Diseases
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Carcinogens and Genotoxicity Assessment
- Medical Coding and Health Information
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiation Dose and Imaging
- Viral Infections and Immunology Research
- Diabetes and associated disorders
- Autoimmune and Inflammatory Disorders
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Gut microbiota and health
- Renal Diseases and Glomerulopathies
- Healthcare cost, quality, practices
- Oral microbiology and periodontitis research
- Inflammatory Bowel Disease
- Cystic Fibrosis Research Advances
Central State Medical Academy
2022-2024
VA Nasonova Scientific Research Institute of Rheumatology
2015-2023
State Scientific Center of the Russian Federation - Federal Medical Biophysical Center named after A.I. Burnazyan
2019-2022
Ministry of Health of the Russian Federation
2020
Federal Medical-Biological Agency
2018-2019
Central Clinical Hospital and Polyclinic
2009
Medico
2001
Background: Patients’ needs and perspectives are important determinants of treatment success in rheumatoid arthritis (RA). Assessing patients’ can help identify unmet enhance the understanding benefits. Objective: The SENSE study assessed impact inadequate response to disease-modifying antirheumatic drugs (DMARDs) on satisfaction, disease outcomes, patient related RA management. Methods: was a noninterventional, cross-sectional conducted 18 countries across Europe, Asia, South America. Adult...
Background The COVID-19 pandemic has had a significant impact on public health. However, the of infection during pregnancy microbiome mother and her newborn child still remains poorly understood. Methods This study involved 94 mother-child pairs whose mothers 44 newborns as control group recruited in 2018. Stool samples were collected from women before delivery infants at 5–7 days after birth used for 16S rRNA sequencing. Results We found that microbiomes exposed utero to showed decreased...
The undoubted and legitimate interest of investigators in comorbidities rheumatic diseases has not faded the past decade; however, concept multimorbidity yet been integrated into either clinical practice or rheumatology researches. The terms comorbidity are frequently always consciously used as interchangeable, which leads to some confusion their terminology accordingly development further research strategies. concepts of concurrent pathology mutually exclusive contradictory to each other,...
Ankylosing spondylitis (AS) is commonly characterized by clonal expansions of T cells. However, these populations are poorly studied and their role in disease initiation progression remains unclear. Here, we performed mass sequencing TCR V beta libraries to search for the expanded cell clones two AS patients. A number comprising more than 5% corresponding family were identified both For first time, shown be stably abundant blood samples patients prolonged period (1.5 2.5 years patients,...
Aim. Study of spectrum, frequency and risk factors comorbid infections in rheumatic diseases (RD) the stationary contingent patients hospitalized FSBI RIR named after V.A. Nasonova within 1 year. Patients methods. The study included 245 with RD: 122 suffered from rheumatoid arthritis, 62 - systemic lupus erythematosus, 61 scleroderma. All were interviewed by a doctor-researcher filled questionnaire. If necessary, additional information was obtained during analysis medical records. Results....
The World Health Organization assigns cardiovascular diseases, cancers, chronic respiratory as well diabetes mellitus and some other nosological entities, including mental musculoskeletal disorders, to main non-communicable diseases. These are considered be a major public health challenge of the 21st century. In this case, one patient frequently has set several age-related diseases that develop simultaneously or sequentially. management these patients requires an integrated approach based on...
Objective : a comparative study of the peculiarities pharmacotherapy rheumatoid arthritis (RA) in presence and absence interstitial lung disease (ILD). Material methods . The included 1034 patients with active RA who met 2010 ACR/EULAR criteria. Patients were divided into two groups: ILD according to high-resolution computed tomography lungs (n=82) without or other types chronic obstructive pulmonary diseases, including bronchial asthma (52 excluded; n=900). Based on medical documentation,...
As of now, impaired immune homeostasis the intestinal mucosa in genetically predisposed individuals is considered to be one major components pathogenesis spondyloarthritis (SpA), which leads to systemic chronic inflammation. The results recent studies may suggest that interleukin-23/interleukin-17 (IL-23/IL-17) axis plays a leading role development these diseases. multifactorial SpA are characterized by not only hyperproduction IL-23, but also change cell target susceptibility this cytokine...
The widespread introduction into clinical practice of modern approaches to the treatment rheumatoid arthritis (RA), rational use traditional and targeted antirheumatic drugs can effectively suppress inflammatory activity, restrain progression disease improve quality life patients. At same time, in some patients, even after repeated change drugs, it is not possible achieve target level RA activity. Serious difficulties arising management such patients raised question identifying a special...
Objective: to compare the course of disease and therapy in rheumatoid arthritis (RA) patients who meet do not criteria for difficult- to-treat RA (D2T). Patients methods. The study included met 2010 ACR/EULAR were hospitalized V.A. Nasonova Research Institute Rheumatology from March October 2021. All underwent a conventional clinical laboratory examination, radiography hands distal feet, radiological stage according Steinbroker was assessed. To determine inflammatory activity, DAS28-ESR...
The problem of comorbidity is widely discussed in modern medical literature. Its role rheumatic diseases particular interest due to their multifactorial nature and the involvement a wide range pathogenetic mechanisms. For many years, researchers around world have noted correlations between presence active autoimmune disorders complicated course cardiovascular diseases. A deeper understanding mechanisms at present stage development rheumatology allows us take fresh look relationship...
In Russia, as well throughout the world, use of glucocorticoids (GC) in treatment rheumatoid arthritis (RA) is widespread, often going beyond recommendations for both duration and dose regimen, which makes it relevant to study long-term consequences such a "wrong" (EULAR, 2022) GC RA therapy. Of 1143 patients with active (ACR/EULAR 2010), two groups were formed: A (n=782) more than 6 months experience systemic GC; group B (n=245) - no taking GC. The cumulative disease index (CIRS) was used...
Assessing the status of a patient with rheumatoid arthritis allows one to obtain information necessary choose appropriate management tactics for patient. The use quantitative methods in routine practice determine inflammatory activity is basis development standardized recommendations and provides substantial improvement quality health care. At same time, accumulated experience suggests that existing summary indices do not always allow correctly disease activity. paper discusses factors can...
Aim. To compare the features of course disease and therapy in rheumatoid arthritis (RA) patients who meet criteria difficult-to-treat RA (D2T). Materials methods. The study included 505 (ACR/EULAR 2010). Rheumatologist experts discussed all patients, since treatment ware perceived as problematic and/or insufficient. All had at least one following signs: activity is no lower than moderate; inability to reduce dose glucocorticoids low; rapid radiological progression; symptoms causing a...
There have been now prerequisites for changing the scientific view of etiology and pathogenesis spondyloarthritis (SpA). An important role is assigned to dysfunction disintegration so-called barrier organs that make protection man between his internal milieu environment. update on cellular molecular mechanisms in SpA permits rheumatologists offer a hypothesis concept organ disease as preclinical stage diseases included group. reason think this process involves individual genetic immune...
Relevance. Life expectancy of cystic fibrosis patients mostly depends on the degree respiratory system damage caused by opportunistic microorganisms, which is due to fact that 90-95% deaths are lung infections. Goal. To define epidemiologic characteristics chronic infection most common agents (S. aureus, P. aeruginosa, B. cepacia-like bacteria (Bcc) and Achromobacter spp.) using a novel in microbiological diagnosis algorithm. Materials methods. Over period 7 years (2008-2016) 300 children...
In 2008, the term cardiorenal syndrome (CRS) was proposed by Acute Dialysis Quality Initiative (ADQI) Group to denote pathological reciprocal conditions involving heart and kidneys, which develop due acute or chronic dysfunction of one organs, followed other one. The problem CRS in patients with rheumatoid arthritis (RA) has not been studied. Of greatest interest is type 5 secondary that occurs systemic diseases, including those RA. Currently, there no doubt risk developing cardiovascular...
комоРбидностЬ в Ревматологии
<h3>Background</h3> In current rheumatology practice concurrent infections produce significant negative impact on patients' morbidity, mortality and quality of life. Based WHO estimations the annual incidence influenza in adult population amounts to 5-10% worldwide. Influenza can lead hospitalization (3 5 million cases per year) even death (250-500 thousand year). Flu its complications rates are higher patients with rheumatic diseases (RD) as compared general population. Therefore,...
Purpose: To study the regeneration processes in treatment of radiation skin lesions with mesenchymal stem cells (MSC) derived from human gingiva and their conditional medium concentrate (CCM) during animal studies.
 Material methods: The includes 80 white male Wistar rats weighing 210 ± 30 g at age 8–12 weeks, randomized into 4 groups (20 animals each): control group (C), did not receive treatment; introduction three times on days 1, 14 21; MSC a dose 2 million per 1 kg CCM estimated...
Systemic sclerosis (SS), is an autoimmune connective tissue disease, the main clinical signs of which are due to disseminated microcirculatory disorders and fibrosis skin viscera. Morphological examinations showed that 80% patients with SS had renal changes, including those unassociated with rheumatic diseases. Whereas prevalence scleroderma crisis now estimated be 2–5%, there considerably often asymptomatic reduction in function (silent uremia), caused by multimorbidity comorbidity....
Hemophagocytic syndrome (HPS) is a rare life-threatening condition caused by massive cytokine release from activated macrophages and lymphocytes. The paper depicts the development of HPS in different infections, malignancies, autoimmune diseases. It describes clinical case hemophagocytic 63-year-old female patient with adult-onset Still's disease high fever accompanied neutrophil leukocytosis drastic left leukocyte count shift, procalcitonin levels, hepatosplenomegaly, edematous syndrome,...
Objective: to compare the course of “rheumatoid disease” in multimorbid patients with and without interstitial lung disease (ILD). Material methods. Two groups were formed 1034 active rheumatoid arthritis (RA) who met 2010 ACR/EULAR criteria: one group ILD identified by high-resolution computed tomography lungs (n=82) another – (n=900). In all patients, estimated glomerular filtration rate (eGFR) was determined using Cockroft–Gault formula. The presence stage chronic kidney (CKD) assessed...