A5067794846- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Vitamin D Research Studies
- Lipoproteins and Cardiovascular Health
- Bone and Joint Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Atherosclerosis and Cardiovascular Diseases
- HIV, Drug Use, Sexual Risk
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Hepatitis C virus research
- Cholesterol and Lipid Metabolism
- Drug Transport and Resistance Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Trace Elements in Health
- Ferroptosis and cancer prognosis
- Homelessness and Social Issues
- Kawasaki Disease and Coronary Complications
- Chronic Disease Management Strategies
University School
2014-2025
MetroHealth
2016-2025
MetroHealth Medical Center
2016-2025
Case Western Reserve University
2016-2025
University Hospitals Cleveland Medical Center
2010-2021
Infectious Disease Consultants
2013-2014
University Hospitals of Cleveland
2010
Introduction Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may trigger autoimmune disease (AD) through initial innate immune activation with subsequent aberrations in adaptive cells leading to AD. While there are multiple reports of incident AD diagnosed after COVID-19, the risk context key circulating strains is unknown. Methods TriNetX, a global, federated, health research network providing access electronic medical records across 74 healthcare organizations, was utilized...
Abstract Background Injectable cabotegravir (CAB)/rilpivirine (RPV) is the only combination long-acting (LA) antiretroviral regimen approved for HIV. RPV may not be effective among individuals with non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance, which has >10% prevalence in many countries. Lenacapavir (LEN) an LA capsid given every 6 months, but been studied other agents. Methods We assembled a case series from 4 US academic medical centers where patients adherence...
Background Studies suggest that vitamin D deficiency is a risk factor for cardiovascular disease and diabetes. Vitamin prevalent in HIV patients but the effect of supplementation on this population unknown. Methods We conducted randomized, double-blind, placebo-controlled trial among 45 HIV-infected adults Cleveland (OH, USA) stable antiretroviral therapy with durable virological suppression baseline serum 25-hydroxyvitamin level ≤20 ng/ml. Participants were randomized 2:1 to D3 4,000 IU...
Background. Little is known about how different antiretrovirals effect inflammation and monocyte activation in human immunodeficiency virus (HIV) infection. Methods. We examined plasma specimens obtained during a randomized, double-blinded trial antiretroviral therapy (ART)–naive HIV-infected adults which compared the efficacy of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (EVG/c/FTC/TDF) with that efavirenz/emtricitabine/tenofovir (EFV/FTC/TDF). From random sample...
Importance Despite higher atherosclerotic cardiovascular disease (ASCVD) risk, people with HIV (PWH) experience unique barriers to ASCVD prevention, such as changing models of primary care. Objective To test whether a multicomponent nurse-led strategy would improve systolic blood pressure (SBP) and non–high-density lipoprotein (HDL) cholesterol level in diverse population PWH receiving antiretroviral therapy (ART). Design, Setting, Participants This randomized clinical trial enrolled at 3...
Background Patients with HIV infection are at increased risk of cardiovascular disease (CVD). Vitamin D insufficiency has been associated CVD in non-HIV populations. This study sought to determine the relationship between vitamin status and markers HIV-related factors HIV-positive patients. Methods on antiretroviral therapy healthy controls were prospectively enrolled. Fasting lipids, glucose, insulin, inflammatory (soluble tumour necrosis factor-α receptor I, interleukin-6 high-sensitivity...
Antiretroviral therapy (ART) has been implicated in bone loss HIV. The role of inflammation and vitamin D is unclear better investigated ART-naive individuals.This a 48-week, prospective cohort study to compare baseline change hip spine mineral density (BMD) measured by dual-energy X-ray absorptiometry HIV-infected, adults healthy controls matched age, sex, race. We also studied associations between markers plasma 25-hydroxyvitamin [25(OH)D] using logistic regression.Forty-seven HIV-infected...
Oxidative stress plays a significant role in atherosclerosis development. HIV infection has been linked with heightened cardiovascular disease risk. HMG-CoA reductase inhibitors may reduce oxidative and subsequently subclinical vascular HIV.This is randomized, placebo-controlled trial to evaluate the effect of rosuvastatin HIV-infected adults on stable antiretroviral therapy low-density lipoprotein less than 130 mg/dl increased inflammation or T-cell activation disease. Changes over 48 weeks...
Background.In chronic human immunodeficiency virus (HIV) infection, plasma cystatin C may be influenced by factors other than glomerular filtration rate such as inflammation.Statins improve improving function or decreasing inflammation.Methods.The Stopping Atherosclerosis and Treating Unhealthy Bone With Rosuvastatin in HIV (SATURN-HIV) trial randomized 147 patients on stable antiretroviral therapy (ART) with low-density lipoprotein cholesterol ≤130 mg/dL to blinded 10 mg daily rosuvastatin...
Background: With the highest rates of HIV/AIDS in United States, Black Americans are still underrepresented HIV medical research. Setting: BRAAVE (NCT03631732) is a randomized, phase 3b, multicenter, open-label US study. Methods: Adults identifying as or African American and virologically suppressed on 2 nucleoside reverse transcriptase inhibitors (NRTIs) plus third agent were randomized (2:1) to switch bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) once daily stay baseline...
Background D-Dimer elevations have been associated with a striking increase in mortality HIV-infected patients. However, has not directly linked to endothelial dysfunction HIV. Methods In this cross-sectional study, we used flow-mediated dilation (FMD) of the brachial artery measure function and several biomarkers systemic inflammation coagulation activation adults on stable antiretroviral therapy HIV-1 RNA levels <400 copies/ml. Multivariable linear regression was model FMD by these...
This is a 96-week prospective cohort study of antiretroviral therapy (ART)–naive HIV-infected adults and matched healthy controls to assess progression carotid intima media thickness (CIMT) its relationship inflammation. Median common artery (CCA) CIMT increased significantly but similarly in both groups [CCA: 0.02 (interquartile range: 0–0.05); P < 0.01 within vs. (0–0.05) mm; controls; = 0.83 between groups]. Change bulb yielded similar results. Independent predictors CCA were higher...
Fat accumulation and insulin resistance remain a threat to the success of antiretroviral therapy (ART). The role gut dysfunction in metabolic complications associated with ART initiation is unclear.
People with HIV are at increased risk of cardiovascular events; thus, care delivery strategies that increase access to comprehensive disease (CVD) management a priority. We report the results multi-component telemedicine-based strategy improve blood pressure control among people HIV—Assess and Adapt Impact COVID-19 on CVD Self-Management Prevention Care in Adults Living (AAIM-High). The AAIM High is virtual adaptation our previously published EXTRA-CVD consisted hypertension education six...
Abstract Glycation is a class of modifications arising from non-enzymatic reactions reducing sugars with proteins, lipids, and/or DNA, generating advanced glycation end-products (AGEs). AGEs are linked to many age-related comorbidities. In response HIV-1 infection, activated T-cells and macrophages shift their predominate metabolism oxidative phosphorylation glycolysis. Increased glycolytic flux enhances AGE formation, which may increase this prospective, multicenter cohort study...
Abstract Background We sought to understand how no, single, and polysubstance use correlate with social drivers of health (SDOH) mental symptoms in persons HIV (PWH). Methods Cross-sectional analysis PWH who do not illicit substances marijuana. Substance was defined by self-report toxicology (urine hair). Surveys evaluated SDOH domains. Linear logistic regression were used assess the associations single substance domains at risk presence symptom compared controls (no use). Results A total...
Thymidine reverse transcriptase inhibitors (tNRTI) are strong of PPAR-gamma and clearly implicated as a cause lipoatrophy. Thiazolidenediaones (TZD), potent agonists, would be expected to beneficial in HIV lipoatrophy, but prior studies have been conflicting. None specifically excluded the use tNRTIs. We report first study individuals treated with tNRTI-sparing regimens using TZD for treatment
Omega-3 fatty acids decrease cardiovascular disease (CVD) mortality possibly due to antiinflammatory effect. Inflammation and endothelial dysfunction likely play a role in the heightened CVD risk HIV. Our goal was evaluate effect of omega-3 primarily on function inflammation HIV-infected adults with moderate stable antiretroviral therapy. We conducted 24-week, randomized, double-blind, placebo-controlled study omega-3-acid ethyl esters 1 g twice day. Flow-mediated dilation (FMD) brachial...