A5021987603- Advanced Polymer Synthesis and Characterization
- Electrochemical sensors and biosensors
- Surfactants and Colloidal Systems
- Supramolecular Chemistry and Complexes
- Supramolecular Self-Assembly in Materials
- Polymer Surface Interaction Studies
- Silicone and Siloxane Chemistry
- Polysaccharides and Plant Cell Walls
- biodegradable polymer synthesis and properties
- Hydrogels: synthesis, properties, applications
- Polymer composites and self-healing
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- Pickering emulsions and particle stabilization
- Fuel Cells and Related Materials
- Photopolymerization techniques and applications
- Biofuel production and bioconversion
- Glycosylation and Glycoproteins Research
- Curcumin's Biomedical Applications
- Advanced Cellulose Research Studies
- Electrospun Nanofibers in Biomedical Applications
- Electrochemical Analysis and Applications
- Carbohydrate Chemistry and Synthesis
- Polymer Science and PVC
Centre de Recherches sur les Macromolécules Végétales
2012-2022
Université Grenoble Alpes
2011-2022
Centre National de la Recherche Scientifique
2011-2022
Institut Carnot PolyNat
2013-2015
Université Joseph Fourier
2011-2013
Institut de Chimie Moléculaire de Grenoble
2011-2013
Institut Carnot ARTS
2013
Centre Hospitalier Universitaire de Grenoble
2013
Centre de Gestion Scientifique
2012
Université de Strasbourg
2009-2010
Topological polymer networks with sliding cross-link points, the "sliding gels" (also called slide-ring gels), are a new class of supramolecular based on intermolecularly cross-linked α-cyclodextrins/poly(ethylene glycol) polyrotaxane precursors. The points such not fixed but can slide along template chain polyrotaxanes. main parameters governing gel properties number cyclodextrins per polyrotaxane, cross-linking density, and nature swelling solvent. Small-angle neutron scattering,...
The colloidal stability together with the tunable aggregation and viscoelastic properties of thermoresponsive polymer-grafted cellulose nanocrystals (CNCs) were investigated. TEMPO oxidation CNCs followed by peptidic coupling in water used to covalently graft thermosensitive Jeffamine polyetheramine M2005 chains onto surface CNCs. resulting polymer-decorated particles (M2005-g-CNCs) exhibited new properties, their ability perfectly redisperse organic solvents such as toluene, dichloromethane...
Background: Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder. Levodopa (L-DOPA) remains gold-standard drug available for treating PD. Curcumin has many pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anti-amyloid, and antitumor properties. Copolymers composed of Poly (ethylene oxide) (PEO) biodegradable polyesters such as (ε-caprolactone) (PCL) can self-assemble into nanoparticles (NPs). This study describes...
n-Heptyl α-d-mannose (HM) is a nanomolar antagonist of FimH, virulence factor E. coli. Herein we report on the construction multivalent HM-based glycopolymers as potent antiadhesives type 1 piliated We investigate glycopolymer/FimH and glycopolymer/bacteria interactions show that efficiently inhibit bacterial adhesion disrupt established cell-bacteria in vitro at very low concentration (0.1 μM mannose unit basis). On valency-corrected basis, are, respectively, 10(2) 10(6) times more than HM...
This paper discusses the thermoresponsive nanoparticles obtained by self-assemblies of nonlinear oligosaccharide-based diblock copolymer systems. These copolymers were synthesized Cu(I)-catalyzed 1,3-dipolar azide/alkyne cycloaddition ("click" reaction) propargyl-functionalized β-cyclodextrin (βCyD) and xyloglucooligosaccharide (XGO) with poly(N-isopropylacrylamide) (PNIPAM) having a terminal azido group prepared atom transfer radical polymerization (ATRP). Elastic quasi-elastic light...
This work describes the synthesis and self-assembly of carbohydrate-clicked rod-coil amphiphilic systems. Copper-catalyzed Huisgen cycloaddition was efficiently employed to functionalize hydrophilic extremity PEG-b-tetra(p-phenylene) conjugates by lactose N-acetyl-glucosamine ligands. The resulting systems spontaneously self-assembled into nanoparticles when dissolved in aqueous media, as evidenced dynamic light scattering (DLS), transmission electron microscopy (TEM), small-angle X-ray...
We demonstrate self-assembly, characterization and bioelectrocatalysis of redox-active cyclodextrin-coated nanoparticles. The nanoparticles with host–guest functionality are easy to assemble permit entrapment hydrophobic redox molecules in aqueous solution. Bis-pyrene-ABTS encapsulated were investigated electrochemically spectroscopically. Their use as electron shuttles is demonstrated via an intraelectron transfer chain between neighboring units clustered particles (Dh,DLS = 195 nm) the...
α-Cyclodextrins (α-CDs) have the ability to form inclusion complexes with poly(ethylene oxide) (PEO) polymer chains. These pseudo-polyrotaxanes (PPRs) can be obtained by quenching an α-CD/PEO mixture in water from 70 °C down a lower temperature (typically range 5 30 °C) thanks favorable interactions between α-CD cavities and PEO Moreover, starting liquid at total mass fraction of 15% w/w °C, formation PPRs time induces white physical gel time, phase separation is observed. We established...
The present paper discusses the controlled self-assembly of sugar-containing block copolymer, maltoheptaose-block-polystyrene (MH(1.2k)-b-PS(4.5k)), into micellar nanoparticles ca. 30 nm radius in aqueous media and their possibility gold encapsulation. Micellar association MH(1.2k)-b-PS(4.5k) was demonstrated by mixing a large amount water (MH-selective solvent) with solution mixture tetrahydrofuran (THF) (PS-selective certain weight fraction [4:1 (w/w) THF/water], where exists as...
The present work demonstrates that α-cyclodextrin/poly(ethylene oxide) (α-CD/PEO)-based polyrotaxanes (PRs) behave as multiblock copolymers. One block type consists of a rod-like tube made 6 to 7 weakly stacked α-CDs threaded along the PEO chain. other one is naked segment, i.e. PR part not covered by α-CDs. This behaviour induces self-organization PRs in concentrated solution dimethyl sulfoxide (DMSO) at room temperature leading formation nano-cylinders. These nano-cylinders consist...
The photo-dimerization of the coumarinated inner compartment nanoparticles is investigated.
Enzymatic biofuel cells are ecofriendly power sources that can deliver μW–mW outputs from renewable substrates, but their stability is a major issue owing to enzyme fragility. The vast majority of reported only generate continuously for relatively short periods time. Here we report novel "solubilized enzymatic fuel cell (SEFC)" concept continuous long-term operation. Avoiding surface immobilization techniques allows biocatalytic activity be easily restored or replenished. exploits freely...
The synthesis and self-assembly of amphiphilic polymers based on unsaturated vegetable oils poly(2-methyl-2-oxazoline) (POx) are reported. Two architectures lipopolymers were explored starting from fatty methyl esters raw oils. latter converted into macroinitiators for cationic ring-opening polymerization (CROP) 2-methyl-2-oxazoline. Firstly, a thiol–ene coupling reaction in the presence mercaptoethanol under UV irradiation was performed to introduce hydroxyl groups that further transformed...
The controlled self-assembly of precise and well-defined photochemically electrochemically active carbohydrate-coated nanoparticles offers the exciting prospect biocompatible catalysts for energy storage/conversion biolabeling applications. Here an aqueous nanoparticle system has been developed with a versatile outer layer host-guest molecule encapsulation via β-cyclodextrin inclusion complexes. A β-cyclodextrin-modified polystyrene polymer was first obtained by copper nanopowder click...
The structure of polyrotaxanes (PRs) based on α-cyclodextrins (α-CDs) threaded onto 22 kg mol−1 poly(ethylene oxide) (PEO) chains in concentrated solution (≈20% w/w) dimethyl sulfoxide (DMSO) was studied by small-angle neutron scattering (SANS) measurements as a function the temperature and complexation degree N (i.e., number α-CDs per PR which ranged from 7 up to 157). A multiblock copolymers behavior revealed for PRs DMSO. This at 43 °C is due presence two kinds blocks alternate along PR....
Abstract Fluorescent vesicles considered as a mimic of natural primitive cells are prepared from poly(3‐hexylthiophene)‐ block ‐poly(3‐ O ‐methacryloyl‐ D ‐galactopyranose) P3HT‐ b ‐PMAGP copolymers. The unique characteristic such vesicular nanostructures is their architecture, which comprises hydrophobic π ‐conjugated P3HT wall stabilized by hydrophilic PMAGP interface featuring glucose units. results this work offer very efficient and straightforward method for engineering well‐controlled...
A series of amphiphilic photo-responsive heterografted copolymers have been successfully synthesized. The random were composed a methacrylate backbone, with various compositions hydrophilic oligomeric 2-methyl-2-oxazoline side chains (OMOx) and hydrophobic long alkyl terminated by coumarin moiety (Cm). Using dynamic (DLS) static light scattering (SLS), transmission electron microscopy (TEM), their self-assembling behavior was studied in water using the nanoprecipitation method. Depending on...
Synthesis and self-assembly behavior in solution of tunable copolymers with amphiphilic grafts based on fatty chain polymethacrylate polyoxazoline.
The conformational impact of environmental biopolymers on metal sorption was studied through Cu xanthan. apparent Cu(2+) complexation constant (logK; + L(-) ↔ CuL(+)) decreased from 2.9 ± 0.1 at pH 3.5 to 2.5 5.5 (ionic strength I = 0.1). This behavior is in contradiction with basic thermodynamics, as usually the higher more cations bind. Our combined titration, circular dichroism and dynamic light scattering study indicated that change observed bond relates a structure xanthan, which...
RAFT polymerization of dimethyl(methacrylamido)dodecylphosphonate (DMADP-(OMe)<sub>2</sub>) was successfully achieved and resulting polymer proved to self-assemble in liquid media.
We report in this contribution that while low molecular weight hemicellulosic building blocks are known not to interact with cellulosic materials, their multivalent presentation on a polymeric scaffold significantly enhanced the binding interactions remarkably same range as those usually observed for lectin-carbohydrate interactions. developed poly(propargyl methacrylate) which we conjugated, by "post-click" reaction, variety of azide reducing-end functionalized xyloglucan oligosaccharides...