A5102020931- Cancer Immunotherapy and Biomarkers
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- Graphene and Nanomaterials Applications
- Electrospun Nanofibers in Biomedical Applications
- Immune cells in cancer
- Bone Tissue Engineering Materials
- Biochemical effects in animals
- Tryptophan and brain disorders
- Adenosine and Purinergic Signaling
- Peptidase Inhibition and Analysis
- RNA and protein synthesis mechanisms
- Dendrimers and Hyperbranched Polymers
- vaccines and immunoinformatics approaches
- Galectins and Cancer Biology
- Calcium signaling and nucleotide metabolism
- RNA Interference and Gene Delivery
- Single-cell and spatial transcriptomics
- Polyamine Metabolism and Applications
- Cutaneous lymphoproliferative disorders research
Memorial Sloan Kettering Cancer Center
2022-2025
Kettering University
2023-2024
National Yang Ming Chiao Tung University
2022-2023
Taipei Medical University
2022
Abstract The immune composition of solid tumors is typically inferred from biomarkers, such as histologic and molecular classifications, somatic mutational burden, PD-L1 expression. However, the extent to which these biomarkers predict landscape in gastric adenocarcinoma—an aggressive cancer often linked chronic inflammation—remains poorly understood. We leveraged high-dimensional spectral cytometry generate a comprehensive single-cell tumors, normal tissue, lymph nodes patients Western...
<p>Supplementary Figure 5</p>
<p>Supplementary Table 2</p>
<p>Supplementary Figure 3</p>
<p>Supplementary Figure 4</p>
<div>Abstract<p>The immune composition of solid tumors is typically inferred from biomarkers, such as histologic and molecular classifications, somatic mutational burden, PD-L1 expression. However, the extent to which these biomarkers predict landscape in gastric adenocarcinoma—an aggressive cancer often linked chronic inflammation—remains poorly understood. We leveraged high-dimensional spectral cytometry generate a comprehensive single-cell tumors, normal tissue, lymph nodes...
<p>Supplementary Table 1</p>
<p>Supplementary Figure 1</p>
<p>Supplementary Figure 2</p>
Abstract The gastric mucosa is characterized by continuous innate immune surveillance and inflammatory signaling, yet a high proportion of carcinomas (GCs) are recalcitrant to immune-directed therapies. mechanisms which GCs evade adaptive within the highly antigenic microenvironment remains unknown. To address this, we collected patient-matched tumor tissue, distant normal metastasis, draining lymph nodes generate large-scale single-cell profiling dataset from 64 patients (n=179 samples,...
Selective autophagy is a defense mechanism by which foreign pathogens and abnormal substances are processed to maintain cellular homeostasis. Sequestosome 1 (SQSTM1)/p62, vital selective receptor, recruits ubiquitinated cargo form autophagosomes for lysosomal degradation. Nab-PTX an albumin-bound paclitaxel nanoparticle used in clinical cancer therapy. However, the role of SQSTM1 regulating delivery efficacy nanodrugs remains unclear. Here we showed that plays crucial drug human lung...
In tissue engineering, foreign body reactions (FBRs) that may occur after the insertion of medical implants are a considerable challenge. Materials currently used in mainly metals non-organic, and lack biocompatibility absence immune regulations lead to fibrosis long periods implantation. Here, we introduce highly biocompatible hybrid interface graphene oxide (GO) collagen type I (COL-I), where topological nanostructure can effectively inhibit differentiation fibroblasts into myofibroblasts....
Guided bone regeneration surgery is an important dental operation used to regenerate enough successfully heal implants. When this technique performed on maxilla sinuses, hyaluronic acid (HLA) can be as auxiliary material improve the graft handling properties. Recent studies have indicated that low-molecular (L-HLA) provides a better ability than high-molecular-weight (H-HLA) analogues. The aim of study was fabricate L-HLA-carboxymethyl cellulose (CMC) hybrid promote while maintaining...
The current abundance of immunotherapy clinical trials presents an opportunity to learn about the underlying mechanisms and pharmacodynamic effects novel drugs on human immune system. Here, we present a protocol study how these responses impact outcomes using large-scale high-throughput profiling cohorts. We describe Human Immune Profiling Pipeline, which comprises end-to-end solution from flow cytometry results computational approaches unsupervised patient clustering based lymphocyte...
Abstract Background: Mantle cell lymphoma (MCL) is an aggressive subtype of B-cell non-Hodgkin that exhibits clinical, pathological, and genetic heterogeneity. While generally thought to be incurable, recently demonstrated clinical activity both chimeric antigen receptor T (CAR-T) cells bispecific antibodies suggest immune-mediated therapies offer substantial benefit in this disease underscores the value understanding mechanisms immune evasion disease. Aim: The aim project uncover distinct...
In tissue engineering, foreign body reactions (FBRs) that may occur after the insertion of medical implants are a considerable challenge. Materials currently used in mainly metals non-organic, and lack biocompatibility absence immune regulations lead to fibrosis long periods implantation. Here, we introduce highly biocompatible hybrid interface graphene oxide (GO) collagen type I (COL-I), where topological nanostructure can effectively inhibit differentiation fibroblasts into myofibroblasts....