A5050848678- Visual perception and processing mechanisms
- Neurobiology of Language and Bilingualism
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Cerebrovascular and Carotid Artery Diseases
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Dementia and Cognitive Impairment Research
- Genetics, Bioinformatics, and Biomedical Research
- Olfactory and Sensory Function Studies
- Gaze Tracking and Assistive Technology
- Action Observation and Synchronization
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Reading and Literacy Development
- Language Development and Disorders
- Categorization, perception, and language
- Vestibular and auditory disorders
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
New York University
2021-2025
New York University Abu Dhabi
2022-2023
Massachusetts General Hospital
2020-2021
Harvard University
2020-2021
<title>Abstract</title> Microsaccades and pupil dynamics exhibit canonical temporal profiles, providing insights into perceptual cognitive processes. are typically suppressed with respect to expected stimulus onset followed by a rebound baseline rates. Here, we investigated whether how the of microsaccades dilation vary task difficulty for motion perception task. We hypothesized that jointly delays microsaccade rates time peak when discriminating direction. Human observers discriminated...
Abstract The fundus of the superior temporal sulcus (FST) in macaque monkeys is implicated processing complex motion signals, yet a human homolog remains elusive. To better understand neural mechanisms underlying analysis signals humans, it crucial to if and where region homologous FST exists. Here, we considered potential localizers evaluated their effectiveness delineating putative (pFST) from two nearby motion-sensitive areas, hMT MST, humans. Nine participants underwent fMRI scanning...
The discriminability of motion direction is asymmetric, with some directions that are better discriminated than others. For example, discrimination near the cardinal axes (upward/downward/leftward/rightward) tends to be oblique directions. Here, we tested for multiple at polar angle locations. We found three systematic asymmetries. First, a large advantage in cartesian reference frame – Second, moderate radial (inward/outward) and tangential (clockwise/counterclockwise) other Third, small...
Abstract In this cross-sectional study, we examined the relationship between cortical thickness and performance on several verbal repetition tasks in a cohort of patients with primary progressive aphasia order to test predictions generated by theoretical accounts phonological working memory that predict content buffers left posterior inferior frontal sulcus supramarginal gyrus. Cortical surfaces were reconstructed from magnetic resonance imaging scans 42 participants diagnosed aphasia. was...
Exogenous attention, a powerful adaptive tool that quickly and involuntarily orients processing resources to salient stimuli, has traditionally been studied in the lower-resolution parafoveal peripheral visual field.1-4 It is not known whether how it operates across 1° central fovea where resolution peaks.5,6 Here we investigated dynamics of exogenous attention foveola. To circumvent challenges posed by fixational eye movements at this scale, used high-precision eye-tracking gaze-contingent...
Abstract Data are mixed on whether patients with semantic variant primary progressive aphasia exhibit a category-selective deficit for animate objects. Moreover, there is little consensus regarding the neural substrates of this deficit, though prior literature has suggested that perirhinal cortex and lateral posterior fusiform gyrus may support memory functions important processing In study, we investigated exhibited objects in word-picture matching task, controlling psycholinguistic...
The fundus of the superior temporal sulcus (FST) in macaques is implicated processing complex motion signals, yet a human homolog remains elusive. Here we considered potential localizers and evaluated their effectiveness delineating putative FST (pFST), from hMT MST, two nearby motion-sensitive areas humans. Nine healthy participants underwent scanning sessions with 2D 3D localizers, as well population receptive field (pRF) mapping. We observed consistent anterior inferior activation...
Abstract In this cross-sectional study, we examined the relationship between cortical thickness and performance on several verbal repetition tasks in a cohort of patients with primary progressive aphasia (PPA) order to test predictions generated by theoretical accounts phonological working memory (PWM) that predict content buffers left posterior inferior frontal sulcus (pIFS) supramarginal gyrus (SMG). Cortical surfaces were reconstructed from magnetic resonance imaging scans 42 participants...
INTRODUCTION. Microsaccades, or small recurring eye movements, typically occur ~1-2 times per second. Although generally considered involuntary, the characteristics of these movements are task-dependent and affect performance. For example, microsaccades flexibly allocated to precisely relocate gaze during high acuity tasks in fovea suppressed prior onset a stimulus outside motion discrimination task. Here we investigated whether how microsaccade rates adaptively modulated by trial difficulty...
Event Abstract Back to Quantifying the Differentiated Trajectory of Wernicke’s-like Presentation Logopenic Variant Primary Progressive Aphasia (lvPPA) Jeanne Gallée1*, Jessica Collins2, 3, Claire Cordella2, Rania Ezzo2, Shalom Kim2, Bradford C. Dickerson2, 3 and Megan Quimby2 1 Harvard University, United States 2 Massachusetts General Hospital, Medical School, (PPA) is a neurodegenerative aphasic syndrome with devastating effects on language. The current study focuses logopenic variant PPA...
The effects of exogenous attention in the visual periphery have been studied extensively. Yet, it is not well-known if this type can be fine-tuned foveola, 1-degree foveal region where resolution highest. Here, we addressed issue by investigating temporal dynamics inhibition return. This phenomenon typically associated with attention, and involves suppression a stimulus that had recently attended to. A classic spatial cueing paradigm was used. entire array scaled size to fit within foveola....
Abstract Background Approximately 5% of the 5.6 million (∼280,000) Americans with Alzheimer’s disease (AD) develop symptoms at age 65 or younger and are classified as having early‐onset AD (EOAD). Although EOAD late‐onset (LOAD) share same pathologic substrate, there notable differences in their clinical biological phenotypes. The Longitudinal Early‐onset study (LEADS) is a multi‐site, observational biomarker EOAD. In present we utilized currently available LEADS imaging data to explore...
Abstract Background White matter (WM) hypointensity volume in T1 MRI correlates strongly with T2 hyperintensities and both are typically associated advancing age vascular brain injury (VBI). Recent research has suggested that Alzheimer’s Disease (AD) neuropathologic changes (ADNC) also increases WM volume. Sporadic early onset AD (EOAD) patients provide a unique model to examine the relationship between ADNC biomarkers absence of advanced age, cardiovascular injury, or autosomal dominant...
Abstract Background Primary Progressive Aphasia (PPA) is a rare neurodegenerative disorder characterized by progressive language impairment and three clinical phenotypes: semantic variant (svPPA), logopenic (lvPPA) non‐fluent (nfvPPA). The goals of the present study were to 1) identify group brain atrophy “signatures” each PPA phenotype, 2) determine degree individual variability in spatial extent within 3) explore ability machine learning algorithm classify patients based on regional...
Abstract Background Studies of patients with impaired semantic memory have identified cases a category‐selective deficit (CSSD) for living things—a disproportionate loss animate versus inanimate items. Data are mixed on whether variant primary progressive aphasia (svPPA) exhibit CSSD, in part because measurement can be confounded by psycholinguistic variables. Furthermore, there exists little consensus regarding the neural substrates CSSD.Here we examine (1) effect animacy single word...
Rationale. There are several perceptual asymmetries associated with motion sensitivity, each of which has been investigated independently. Sensitivity is greater: (1) for directions toward/away from the center gaze than tangential trajectories (radial direction advantage); (2) locations in lower upper visual field (LVF and (3) cardinal oblique (cardinal advantage). Goal. We systematically whether radial advantage occurs across polar angle locations, first tested LVF advantages interact....