A5033704412- Peroxisome Proliferator-Activated Receptors
- NF-κB Signaling Pathways
- Inflammatory mediators and NSAID effects
- Estrogen and related hormone effects
- Retinoids in leukemia and cellular processes
- Antioxidant Activity and Oxidative Stress
- Receptor Mechanisms and Signaling
- Nuclear Receptors and Signaling
- Computational Drug Discovery Methods
- Endoplasmic Reticulum Stress and Disease
- Thyroid Disorders and Treatments
- DNA and Nucleic Acid Chemistry
- Adenosine and Purinergic Signaling
- Animal Genetics and Reproduction
- Animal health and immunology
Brazilian Center for Research in Energy and Materials
2013-2019
Brazilian Biosciences National Laboratory
2013-2019
Universidade Estadual de Campinas (UNICAMP)
2019
Universidade de São Paulo
2015
Laboratório Nacional de Ciência e Tecnologia do Bioetanol
2013-2014
Instituto Colombiano Agropecuario
1993
The peroxisome proliferator-activated receptor γ (PPARγ) is a target for treatment of type II diabetes and other conditions. PPARγ full agonists, such as thiazolidinediones (TZDs), are effective insulin sensitizers anti-inflammatory agents, but their use limited by adverse side effects. Luteolin flavonoid with actions that binds but, unlike TZDs, does not promote adipocyte differentiation. However, previous reports suggested variously luteolin agonist or an antagonist. We show exhibits weak...
Non-steroidal anti-inflammatory drugs (NSAIDs) display anti-inflammatory, antipyretic and analgesic properties by inhibiting cyclooxygenases blocking prostaglandin production. Previous studies, however, suggested that some NSAIDs also modulate peroxisome proliferator activated receptors (PPARs), raising the possibility such off target effects contribute to spectrum of clinically relevant NSAID actions. In this study, we set out understand how receptor-γ (PPARγ/PPARG) interacts with using...
Transcriptional regulation controlled by thyroid hormone receptor (TR) drives events such as development, differentiation, and metabolism. TRs may act either homodimers or heterodimers with retinoid X (RXR). Thyroid T3 preferentially binds TR-RXR heterodimers, which activate transcription through coactivator recruitment. However, it is unclear whether also be responsive to the canonical RXR agonist 9-cis retinoic acid (9C) in context of physiological gene regulation. New structural studies...
Thyroid hormone receptors (TRs) are responsible for mediating thyroid (T3 and T4) actions at a cellular level. They belong to the nuclear receptor (NR) superfamily execute their main functions inside cell nuclei as hormone-regulated transcription factors. These also exhibit so-called 'nonclassic' actions, which other proteins, apart from coregulators nuclei, regulate activity. Aiming find alternative pathways of TR modulation, we searched interacting proteins found that PDIA1 interacts with...