A5101885168- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Essential Oils and Antimicrobial Activity
- Luminescence and Fluorescent Materials
- Animal health and immunology
- interferon and immune responses
- Inflammasome and immune disorders
- Medicinal Plants and Neuroprotection
- Protein purification and stability
- Metal-Organic Frameworks: Synthesis and Applications
- MicroRNA in disease regulation
- Breast Cancer Treatment Studies
- Radiomics and Machine Learning in Medical Imaging
- Crystallography and molecular interactions
- Cancer, Lipids, and Metabolism
- Piperaceae Chemical and Biological Studies
- Organoboron and organosilicon chemistry
- Radical Photochemical Reactions
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
Nanjing Tech University
2019-2023
Air Force Medical University
2020-2021
Xijing Hospital
2020-2021
Shaanxi Normal University
2020
Southern Medical University
2020
University of Science and Technology of China
2019
Central South University
2015
Kaohsiung Chang Gung Memorial Hospital
2012
Chang Gung University
2012
National Sun Yat-sen University
2012
Abstract MIEF2 (mitochondrial elongation factor 2) is one of the key regulators mitochondrial fission. Bioinformatics analysis indicated that high expression predicted a poor prognosis in ovarian cancer patients. However, relationship between and aberrant lipid metabolism OC remains elusive. In this study, we demonstrated significantly promoted synthesis, while has no significant effect on fatty acid uptake oxidation cells. enhanced de novo synthesis through up-regulating sterol regulatory...
Abstract Background Increasing evidence has revealed the close link between mitochondrial dynamic dysfunction and cancer. MIEF2 (mitochondrial elongation factor 2) is outer membrane protein that functions in regulation of fission. However, expression, clinical significance biological are still largely unclear human cancers, especially ovarian cancer (OC). Methods The expression were determined by qRT-PCR, western blot immunohistochemistry analyses tissues cell lines OC. OC vitro vivo growth...
A photo-induced transition-metal-free regioselective hydroborylation of α,β-unsaturated carbonyl compounds is developed. The PhSSPh reagent was employed as the photocatalyst, and NHC-BH3 used boron source. This transformation shows a broad substrate scope provides wide range α-borylcarbonyl molecules in good to excellent yields.
Abstract The aim of this study was to investigate the mechanism by which growth arrest‐specific transcript 5 (GAS5) regulates bladder cancer cells. Bladder samples were collected and tested for experiment. Dual‐luciferase reporter assay used verify downstream target genes GAS5 miR‐21. expression level decreased that miR‐21 increased, indicating a negative correlation between two. Patients with high low had relatively longer survival rates. inhibited cells proliferation promoted apoptosis,...
Abstract Research on new supramolecular synthons facilitates the progress of materials design. Herein, ability sp 2 carbonyl oxygen atoms to act as halogen‐bond acceptors was established through cocrystallization. Four sets compounds, including aldehydes, ketones, esters, and amides, were selected acceptors. In absence strong hydrogen bonds, 14 out 16 combinations donors could form cocrystals, whereby synthon C=O ⋅⋅⋅ X acts main interaction. Further, geometric parameters interaction...
Background: NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is one of the ubiquitin-like proteins which activated by activating enzyme (NAE). The overexpressed NAE can cause a variety diseases such as numerous cancer types and inflammatory diseases. selective inhibition could mediate rate ubiquitination subsequent degradation associated with so to achieve purpose treatment. Objective: In this article, we decided study synthesis screening coumarin scaffold...
Background: NEDD8 activating enzyme (NAE) plays a critical role in various cellular functions carcinomas. The selective inhibition of NAE could mediate the rate ubiquitination and subsequent degradation proteins associated with cancer so as to achieve purpose treatment. Objective: In this article, we decided study synthesis screening 4-amino substituted 2H-chromen-2-one derivatives against cell lines, specifically human pancreatic line BxPC-3. Methods: After twenty targeted compounds,...
A series of di-substituted cinnamic hydroxamic derivatives was designed, synthesized and evaluated as HDAC inhibitors. Compound 5f (HS270) demonstrated potent inhibitory antiproliferative activities. In xenograft model, showed significant antitumor efficacy in tumorbearing mice. Keywords: Antitumor, cinnamic, design, histone deacetylase, HDAC, hydroxamaic acid.
Background: Pancreatic cancer (PC) is one of the cancers with highest mortality rate in world. Therefore, it urgent to understand potential molecular mechanisms PC progression and detect novel original strategies for a targeted therapy. Many reports show that lot are regulated by miR-1275; however, role which miR-1275 plays remains unknown. Our study was conducted explore expression PC. Methods: qRT-PCR used both tissues cell lines. The function cells evaluated luciferase assays through...
Abstract Pancreatic cancer remains clinically challenging because of the lack efficient targeted therapies and high aggressiveness. NEDD8 activating enzyme (NAE) plays a critical role in various cellular functions cancers. Herein, we report synthesis, optimization, evaluation new series pyrido[2,3-d]pyrimidin-7(8 H )-one derivative as highly selective efficacious NAE inhibitors, enabling rapid degradation related substrates potent inhibition BxPC-3 cell proliferation. Moreover, western blot...