A5051096921- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Electrowetting and Microfluidic Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Stress Responses and Cortisol
- Microfluidic and Bio-sensing Technologies
- Neuroendocrine regulation and behavior
New York University
2021-2024
Columbia University
2016
Pingry School
2010
Inhibitory interneurons in the neocortex often connect a promiscuous and extensive fashion, extending "blanket of inhibition" on circuit. This raises problem how can excitatory activity propagate midst this widespread inhibition. One solution to could be vasoactive intestinal peptide (VIP) interneurons, which disinhibit other interneurons. To explore VIP affect local circuits, we use two-photon optogenetics activate them individually mouse visual cortex vivo while measuring their output with...
Interneurons in the medial prefrontal cortex (PFC) regulate local neural activity to influence cognitive, motivated, and emotional behaviors. Parvalbumin-expressing (PV+) interneurons are primary mediators of thalamus-evoked feed-forward inhibition across mouse cortex, including anterior cingulate where they engaged by inputs from mediodorsal (MD) thalamus. In contrast, adjacent prelimbic (PL) we find that PV+ scarce principal thalamorecipient layer 3 (L3), suggesting distinct mechanisms...
Connections from the basolateral amygdala (BLA) to medial prefrontal cortex (PFC) regulate memory and emotion become disrupted in neuropsychiatric disorders. The diverse roles attributed interactions between BLA PFC may reflect multiple circuits nested within a wider network. To examine these circuits, we first used retrograde anterograde anatomy show that rostral (rBLA) caudal (cBLA) differentially project prelimbic (PL) infralimbic (IL) subregions of mouse PFC. Using ex vivo whole-cell...
Cholinergic interneurons (ChIs) in the nucleus accumbens (NAc) play a central role motivated behaviors and associated disorders. However, while activation of ChIs has been well studied dorsal striatum, little is known about how they are engaged NAc. Here, we find that ventral hippocampus (vHPC) paraventricular thalamus (PVT) main excitatory inputs to NAc medial shell. While PVT activates ChIs, vHPC evokes pronounced pause firing through prominent feedforward inhibition. In contrast this...
Mixing of analytes and reagents is a critical difficult step in lab-on-a-chip applications. This paper presents hybrid approach for mixing two laminar aqueous streams microchannel. It consists patterned geometric features electrokinetic actuation along the channel improved performance. The mixer can potentially mix fluid medium from deionized water to electrically conductive fluids (0.2 S m−1) with low voltage supplies (3.5 Vrms). capacity this microfluidic characterized compared that...
ABSTRACT Connections from the basolateral amygdala (BLA) to medial prefrontal cortex (PFC) regulate memory and emotion become disrupted in neuropsychiatric disorders. We hypothesized that diverse roles attributed interactions between BLA PFC reflect multiple circuits nested within a wider network. To assess these circuits, we first used anatomy show rostral (rBLA) caudal (cBLA) differentially project prelimbic (PL) infralimbic (IL) subregions of PFC, respectively. then combined vivo silicon...