A5036479387- Cancer Cells and Metastasis
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Histone Deacetylase Inhibitors Research
- Genetic factors in colorectal cancer
- COVID-19 Clinical Research Studies
- Melanoma and MAPK Pathways
- Occupational and environmental lung diseases
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- RNA modifications and cancer
- Gene expression and cancer classification
- SARS-CoV-2 detection and testing
- Pancreatic and Hepatic Oncology Research
- FOXO transcription factor regulation
- Endoplasmic Reticulum Stress and Disease
- Bacteriophages and microbial interactions
- vaccines and immunoinformatics approaches
- Ideological and Political Education
- interferon and immune responses
- Cancer Immunotherapy and Biomarkers
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Advanced Proteomics Techniques and Applications
- Immune Cell Function and Interaction
Acıbadem University
2024
Bilkent University
2013-2023
Kent Hastanesi
2022-2023
Acıbadem Adana Hospital
2022-2023
Ankara (Czechia)
2016
Abstract Intrinsic and acquired resistance to chemotherapy is the fundamental reason for treatment failure many cancer patients. The identification of molecular mechanisms involved in drug or sensitization imperative. Here we report that tribbles homologue 2 (TRIB2) ablates forkhead box O activation disrupts p53/MDM2 regulatory axis, conferring various chemotherapeutics. TRIB2 suppression exerted via direct interaction with AKT a key signalling protein cell proliferation, survival metabolism...
Background: Prognostic biomarkers for cancer have the power to change course of disease if they add value beyond known prognostic factors, can help shape treatment protocols, and are reliable.The aim this study was identify such colon understand molecular mechanisms leading stratifications based on these biomarkers.Methods Findings: We used an in house R script (SSAT) silico discovery stage-independent using two cohorts, GSE17536 GSE17537, that include 177 55 patients, respectively.This...
Background . There is not yet an agreed adjuvant treatment for melanoma patients with American Joint Committee on Cancer stages III B and C. We report administration of autologous vaccine to prevent disease recurrence. Patients Methods 126 received eight doses irradiated cells conjugated dinitrophenyl mixed BCG. Delayed type hypersensitivity (DTH) response unmodified was determined the days 5 8. Gene expression analysis performed 35 tumors from good or poor survival. Results Median overall...
Despite the availability of various treatment protocols, response to therapy in patients with Acute Myeloid Leukemia (AML) remains largely unpredictable. Transcriptomic profiling studies have thus far revealed presence molecular subtypes AML that are not accounted for by standard clinical parameters or routinely used biomarkers. Such predicted vary chemotherapy targeted therapy. The Renin-Angiotensin System (RAS) is an important group proteins play a critical role regulating blood pressure,...
Aims: Molecular heterogeneity of breast cancer results in variation morphology, metastatic potential and response to therapy.We previously showed that cell line sub-groups obtained by a clustering approach using highly variable genes overlapped almost completely with generated drug cytotoxicity-profile based approach.Two distinct populations thus identified were CSC(cancer stem cell)-like non-CSC-like.In this study we asked whether an mRNA gene signature identifying these two types would...
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Known risk factors for this disease are currently insufficient in predicting mortality. In order to better prognosticate patients with PDAC, we identified 20 genes by utilizing publically available high-throughput transcriptomic data from GEO, TCGA and ICGC which associated overall survival event-free survival. A score generated based on expression matrix of these was validated two independent cohorts. We find that...
The diagnosis of new variants and monitoring their potential effects on diagnosis, therapeutics, vaccines by genomic sequencing is essential to manage global public crises. In the current study, spike-genome next-generation was generated from 492 SARS-CoV-2 isolates evaluate mutations in Turkey April 2021 February 2022. variant analysis performed using (Coronavirus Antiviral Resistance Database (CoV-RDB) Stanford University). We revealed that lineages Alpha (B.1.1.7), Beta (B.1.351), Delta...
Tumor-specific, coordinate expression of cancer-testis (CT) genes, mapping to the X chromosome, is observed in more than 60% non-small cell lung cancer (NSCLC) patients. Although CT gene has been unequivocally related DNA demethylation promoter regions, underlying mechanism leading loss methylation remains elusive. Polymorphisms enzymes within 1-carbon pathway have shown affect S-adenosyl methionine (SAM) production, which sole methyl donor cell. Allelic variants several this associated with...
Transcriptomic phenotypes defined for melanoma correlate with sensitivity to MEK, SRC and HSP90 inhibitors.
Our current understanding of cancer-stem cells (CSCs) is that they are slow growing, generally mesenchymallike capable generating tumors. Convincing evidence for the existence such comes from recent lineage tracing experiments. CSCs have been reported as being resistant to conventional drug treatment and considered responsible failure chemotherapy. Recently, several databases aiming genetic characterization a large number cancer cell lines made publicly available. In addition gene expression...
This study determined SARS-CoV-2 variations by phylogenetic and virtual phenotyping analyses.
Melanoma is a highly aggressive cancer with poor prognosis. Although more than 80% of melanomas harbor an activating mutation in genes within the MAPK pathway, which are mutually exclusive, usefulness therapies targeting pathway impeded by innate and/or acquired resistance most patients. In this study, using melanoma cells, we report efficacy recently developed pyrazolo[3,4-d]pyrimidine derived c-Src inhibitor 10a and identify molecular signature predictive chemosensitivity. We show that...
This research paper presents a novel approach to identifying biomarkers that can be used prognosticate patients with triple-negative breast cancer (TNBC) eligible for neoadjuvant therapy. The study utilized survival and RNA sequencing data from cohort of TNBC identified 276 genes whose expression was related in such patients. gene were then classify into two major groups based on the presence or absence Wingless/Integrated-pathway (Wnt-pathway) mesenchymal (Mes) markers (Wnt/Mes). Patients...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Known risk factors for this disease are currently insufficient in predicting mortality. The only FDA approved prognostic biomarker PDAC patients CA19-9. This, along with AJCC TNM staging and performance status, considered important indicators clinical practice. In order to better prognosticate PDAC, we identified a novel panel of genes by utilizing publically available microarray RNAseq data tumors from GEO...
The prognosis of malignant pleural mesothelioma (MPM) is poor, with a limited survival time. In this study, we aimed to examine expression levels genes selected from relevant literature and utilize in silico methods determine whose could reflect the patients MPM by ex-vivo validation experiments.The study group consisted 54 treated chemotherapy. Expression 6 - midkine (MDK), syndecan-1 (SDC1), hyaluronan synthase-2 (HAS2), sestrin-1 (SESN1), laminin subunit alpha-4 (LAMA4), fibulin-3 (FBLN3)...
Abstract Breast cancer shows plasticity in terms of classification. Upon drug treatment and metastasis some tumors switch to another subtype leading loss response therapy. In this study, we ask the question which molecular subclasses breast are more switchable upon therapy metastasis. We used silico data classify PAM50 classes before after using gene expression data. Similar analysis was performed for primary their metastatic growth. Our showed that both scenarios shift from one class...
Objective: Triple negative breast cancer (TNBC) is one of the most metastatic, aggressive with poor prognosis types cancers. There currently no standard molecular-targeted treatment for TNBC. Therefore, new therapeutics should be developed. The aim this study was to determine effect AZD7762 on several cell lines and evaluate RBFOX2 gene expression levels as a marker show sensitivity drug. Materials Methods: cytotoxic determined by sulforhodamine B method. were quantitative real-time...
The rapid spread of the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which causes coronavirus disease 2019 (COVID-19) facilitated emergence numerous variants. present study aimed to investigate prevalence and change important "S" protein variants such as N501Y, DelH69/ 70, E484K in SARS CoV-2 PCR positive patients diagnosed with COVID-19 who have referred a private hospital within period that mutations were detected during pandemic.One hundred eighty-seven been due...
Abstract Background The bladder cancer (BC) pathology is caused by both exogenous environmental and endogenous molecular factors. Several genes have been implicated, but the pathogenesis of BC its subtypes remains debatable. bioinformatic analysis evaluates high numbers proteins in a single study, increasing opportunity to identify possible biomarkers for disorders. Methods aim this study identification using several analytical tools methods. normal samples were compared each probeset with T...