A5102708648- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Escherichia coli research studies
- Veterinary medicine and infectious diseases
- interferon and immune responses
- Viral Infectious Diseases and Gene Expression in Insects
- Ubiquitin and proteasome pathways
- Viral Infections and Vectors
- Cancer Research and Treatments
- Virus-based gene therapy research
- RNA modifications and cancer
Chinese Academy of Agricultural Sciences
2017-2020
Type I interferon (IFN) plays an essential role in the host innate immune responses. Several ubiquitin-conjugating enzyme (E2) family members were reported to regulate type IFN production and antiviral However, molecular mechanisms are still not fully understood. Here, we report that UBE2S acts as a negative regulator signaling pathway. Ectopic expression of inhibits responses enhances viral replications, whereas deficiency suppresses replications both vitro vivo. Inhibition І by is...
Abstract Background Bovine viral diarrhea virus (BVDV) is a single stranded RNA with worldwide distribution that belongs to the genus Pestivirus, family Flaviviridae. Infection of cattle BVDV causes range clinical syndromes and can result in major economic losses. Here, we reported two isolates obtained from serum collected Shandong province, China commercial fetal bovine serum. Results The isolates, named BJ-2013 BJ-2016, were both members Pestivirus A, belonged genotype 1a 1b,...