A5038392890- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Bone and Joint Diseases
- Spondyloarthritis Studies and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- COVID-19 epidemiological studies
- Autoimmune and Inflammatory Disorders Research
- Vasculitis and related conditions
- COVID-19 Pandemic Impacts
- Inflammatory Myopathies and Dermatomyositis
- Gout, Hyperuricemia, Uric Acid
- COVID-19 and Mental Health
- Heterotopic Ossification and Related Conditions
- Tendon Structure and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hematological disorders and diagnostics
- Chronic Lymphocytic Leukemia Research
- Salivary Gland Disorders and Functions
- Sarcoidosis and Beryllium Toxicity Research
- Infectious Diseases and Tuberculosis
- Viral Infections and Immunology Research
- Coal and Coke Industries Research
- Cytokine Signaling Pathways and Interactions
Amrita Institute of Medical Sciences and Research Centre
2017-2024
Amrita Vishwa Vidyapeetham
2017-2021
Aims Community College
2021
Command Hospital
2009-2016
All India Institute of Medical Sciences
2003-2008
Army Hospital Research and Referral
2007
In Brief Objective Inter-individual variations to methotrexate (MTX) response among rheumatoid arthritis (RA) patients have been attributed clinical heterogeneity and genetic influencing MTX pharmacology. this study, we analyzed the association of polymorphisms in ATIC, AMPD1, ADA, ADORA2A from purine biosynthetic pathway with RA north India. We also assessed cumulative contribution these together those receptor–metabolizer–transporter folate genes that previously investigated. Methods...
Methotrexate (MTX) is the drug of choice for rheumatoid arthritis (RA) but effective only in around 60% treated patients. Bioavailability MTX may be a major determinant response status and this governed by variations receptor transporter genes responsible polyglutamation deconjugation. We investigated contribution single nucleotide polymorphisms (SNPs) RFC, FOLR1, FPGS, GGH MDR1 to RA patients from North India.RA recruited using American College Rheumatology criteria, were categorized into...
The coexistence of raised blood pressure (BP) in people with type 2 diabetes mellitus (T2DM) is a major contributor to the development and progression both macrovascular microvascular complications. aim our study was determine prevalence uncontrolled BP its associated factors persons T2DM district Kerala. Methods conducted Ernakulam Kerala, total 3,092 individuals were enrolled after obtaining consent. Those “above or equal 140 mmHg” and/or 90 thus considered have BP. If >140 mmHg,...
Rheumatoid arthritis (RA) is a polyarticular disorder with many extra-articular features. Cardiovascular disorders, including heart failure (HF), are the leading causes of mortality in RA patients. We studied prevalence left ventricular dysfunction (LVD) patients RA.In this cross-sectional study, we evaluated 100 consecutive (aged >18 years and duration >1 year) for presence LVD. excluded known cardiac systemic disorders that may contribute to LVD defined by either systolic (LVSD) or...
Vaccination is the most important prophylactic measure taken to curb COVID-19 pandemics. This study was undertaken throw light on safety of Covishield vaccine among health care workers (HCWs) and assess co-variates associated with incidence adverse events.
The reduced level of complement receptor 1 (CR1) on erythrocytes is speculated as a key mechanism contributing to immune complex (IC) overload and exaggerated (C) activation in systemic lupus erythematosus (SLE). Comparatively, fewer studies documented lower levels CR1 leukocytes glomerular podocytes this disease. decline E-CR1 largely believed an acquired phenomenon caused due the proteolytic cleavage from erythrocyte membrane. underlying expression nucleated cells under constant...
Renal involvement in systemic sclerosis (SSc) either the form of scleroderma renal crisis (SRC) or nonrenal abnormalities has been reported to be range 60-80%. is thought rare Indian patients with SSc. However, there paucity data.To study frequency and pattern SSc.A single center prospective, cross sectional study.We prospectively evaluated SSc attending Rheumatology Clinic. All were for involvement. underwent measurement blood pressure, urine examination, glomerular filtration rate (GFR)...
Background: We compared the diagnostic accuracy of procalcitonin, C-reactive protein (CRP), and ferritin in differentiating an infectious aetiology versus disease flare children with systemic juvenile idiopathic arthritis (sJIA). Methods: This prospective study included 52 consecutive hospitalisations 25 diagnosed sJIA (International League Associations for Rheumatology 2001) presenting a fever to rheumatology department quaternary care centre. categorised post-discharge as flare, depending...
Background: In this study the clinical outcomes of different biologics agents in patients with rheumatoid arthritis (RA) has been appraised. Methods: Nineteen RA DMARD failure were administered etanercept (n = 7) or infliximab 12), and 17 TNFi rituximab 13), abatacept 2), tocilizumab 2) as per 2013 EULAR guidelines. Baseline demographic details, disease duration, factor, anticyclic citrullinated peptide antibody obtained. To monitor activity, activity score 28-erythrocyte sedimentation rate...
Sulfasalazine has been widely used in treatment of rheumatoid arthritis and spondyloarthritis. This study aims to assess persistence with sulfasalazine also frequency severity adverse drug reactions (ADRs) encountered this very well-established disease-modifying anti-rheumatoid drug.This retrospective was done 1,114 patients from medicine rheumatology outpatient departments six centers across India. The inclusion criteria taking sulfasalazine. Patients receiving for or spondyloarthritis were...
The assessment of disease activity in patients with ankylosing spondylitis (AS) continues to be a challenging issue. currently available markers like C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) show poor correlation clinical activity. There is need for good biomarkers assess We explored serum nitrite, stable end product metabolism NO, which known rise inflammation, as potential biomarker AS. To compare the levels nitrite between AS healthy controls correlate four (ASAS)...
Tennis elbow or lateral epicondylitis is a chronic, painful condition and often resistant to conventional therapy. We evaluated the benefits of combined steroid lignocaine injection in cases tennis elbow.In this prospective, interventional study, we included chronic patients analgesics physiotherapy. The pain was assessed by visual analog scale (VAS), with baseline VAS >4. All were given local infiltration at site methylprednisolone (1 ml) peppering technique. primary outcome change from end...
Ankylosing Spondylitis (AS) with non-steroidal anti-inflammatory drug (NSAID) therapeutic failure is treated biologics.To compare the clinical outcomes of different biologics for Asian Indian patients AS who have NSAID failure.Thirty-five were administered Etanercept (n=15) (50mg SQ, weekly) or Infliximab (n=20) (5mg/kg IV every 2(nd) month) based on patient convenience physician discretion as per 2015 ACR/SAA/SPARTAN recommendations. Baseline demographic details, time to diagnosis, disease...
Introduction: Diagnosis and initial management of diabetes mellitus (DM) in the young are clinical dilemma. Gliptins may be a safer more effective option than sulfonylureas. Few Indian studies have addressed this issue relevance. Aim: To compare use sitagliptin glimepiride as early add-on drugs along with metformin patients DM to achieve optimum glycemic targets. Methods: This was prospective, open-label, cohort study set tertiary care hospital North India. Newly diagnosed ≤35 year age were...
Advances in bioinformatics, information technology, advanced computing, imaging techniques are changing fundamentally the way physicians define, diagnose, treat, and prevent disease. New disciplines - Artificial Intelligence, Machine Learning, Computational Biology improving healthcare. Digital health solutions have immense scope. Education practice need to keep pace.We aimed at assessment of "Technology proficiency" required by medical graduates its implementation, if found useful. All this...
Background: The COVID-19 lockdown has caused increased psychological disturbances among the student community. Medical students are susceptible to mental stressors and thus more likely be affected by pandemic. aim of study was determine prevalence depression, anxiety stress in medical during Kerala along with associated socio-demographic factors.Methods: A web-based cross-sectional conducted a southern state India. Collected data included details scale-21 (DASS-21). Chi square test used...
Paederus dermatitis is the skin irritation resulting from contact with haemolymph of certain rove beetles, a group that comprised by genus Paederus. In May 2018, there was an increase in number residential students reporting burning lesions. this context, outbreak investigation conducted. A team public health specialists visited these buildings and premises. The inmates who were affected interviewed examined. Suspected insects collected entomologically evaluated Zoological Survey India. On...