A5100688581- Hepatocellular Carcinoma Treatment and Prognosis
- Ocular Oncology and Treatments
- Ergonomics and Musculoskeletal Disorders
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Sarcoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pulmonary Hypertension Research and Treatments
- Brain Metastases and Treatment
- Cardiovascular Function and Risk Factors
- Glioma Diagnosis and Treatment
- Lysosomal Storage Disorders Research
- Kawasaki Disease and Coronary Complications
- Infrared Thermography in Medicine
- Thermoregulation and physiological responses
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Chemotherapy-induced cardiotoxicity and mitigation
- RNA modifications and cancer
- Tumors and Oncological Cases
- Renal and related cancers
- Coronary Artery Anomalies
Capital Medical University
2016-2025
Beijing Chao-Yang Hospital
2021-2025
Beijing Tongren Hospital
2015-2024
Peking University Cancer Hospital
2024
Peking University
2024
Tongren Hospital
2020-2024
University of Oxford
2023
Walter and Eliza Hall Institute of Medical Research
2022-2023
The University of Melbourne
2023
Science Oxford
2023
Adenovirus (Ad)-based vectors have great potential for use in the gene therapy of multiple diseases, both genetic and nongenetic. While capable transducing dividing quiescent cells efficiently, Ad been limited by a number problems. Most are engineered such that transgene replaces E1a, E1b, E3 genes; subsequently replication-defective vector can be propagated only human 293 supply deleted E1 functions trans. Unfortunately, high titers E1-deleted has repeatedly demonstrated to result low-level...
Molecular docking programs are primarily designed to align rigid, drug-like fragments into the binding sites of macromolecules and frequently display poor performance when applied flexible carbohydrate molecules. A critical source flexibility within an oligosaccharide is glycosidic linkages. Recently, Carbohydrate Intrinsic (CHI) energy functions were reported that attempt quantify torsion angle preferences. In present work, CHI-energy have been incorporated AutoDock Vina (ADV) scoring...
Abstract Mutant TP53 proteins are thought to drive the development and sustained expansion of cancers at least in part through loss wild-type (wt) tumour suppressive functions. Therefore, compounds that can restore wt functions mutant expected inhibit tumours expressing TP53. APR-246 has been reported exert such effects malignant cells is currently undergoing clinical trials several cancer types. However, there evidence may also kill do not express To support it important understand its...
Renal tubule cells can recover after they undergo AKI (acute kidney injury). An incomplete repair of renal tubules result in progressive fibrotic CKD (chronic disease). Studies have revealed the relationship between tubular epithelial and fibrogenesis. However, underlying mechanism remains unclear. Hippo pathway components were evaluated complete/incomplete I/R (ischaemia/reperfusion) rat models, HK-2 human biopsy samples. We found that expression levels changed dynamically during...
Blockage of the renin-angiotensin II system (RAS) prevents or delays albuminuria in diabetic patients. The aim this study was to investigate inhibitory mechanism angiotensin receptor blocker olmesartan on a murine model nephropathy.Male db/db mice were fed with placebo 20 mg/kg by daily gavage for 12 weeks. Conditionally immortalized mouse podocytes treated glucose, II, p38 inhibitor s8307 different experimental conditions after differentiation.Olmesartan reduced without change body weight...
Retinoblastoma is the most common primary intraocular tumor and more attention has been paid to developing countries. This study was aimed evaluate clinical features, treatment, prognosis of retinoblastoma patients with central nervous system (CNS) metastasis in Beijing Tongren Hospital, one largest tertiary eye centers China.Clinical data 31 consecutive CNS metastases, who were diagnosed at Department Pediatrics Hospital between September 2005 December 2015, retrospective analyzed.The...
Orthodontic pain that is induced by tooth movement an important sequela of orthodontic treatment and has a significant effect on patient quality life. Studies have shown the high expression transient receptor potential vanilloid 1 (TRPV1) in trigeminal ganglions plays vital role transmission modulation orofacial pain. However, little known about TRPV1 In this study, male Sprague-Dawley rats were randomly assigned to six groups study tooth-movement The levels mRNA protein determined real-time...
To assess right ventricular (RV) function and RV-pulmonary arterial (PA) coupling by three-dimensions echocardiography investigate the ability of RV-PA to predict adverse clinical outcomes in patients with precapillary pulmonary hypertension (PH).
This retrospective study was designed to explore the relationship between right ventricular fibroblast activation measured by protein inhibitor (FAPI) imaging and myocardial deformation Speckle‑tracking Echocardiography (STE) in patients with pulmonary hypertension (PH). Clinical data of PH were collected [15 chronic thromboembolic (CTEPH), 4 PAH, 1 unclear and/or multifactorial mechanisms]. All underwent FAPI echocardiography within one month. activity ventricle higher than that blood pool...
Dietary protein restriction is one major therapy in chronic kidney disease (CKD), and ketoacids have been evaluated CKD patients during restricted-protein diets. The objective of the present study was to compare efficacy a low-protein diet supplemented with (LPD+KA) alone (LPD) halting development renal lesions CKD. 5/6 Nephrectomy Sprague–Dawley rats were randomly divided into three groups, fed either 22 % (normal-protein diet; NPD), 6 or 5 plus 1 for 24 weeks. Sham-operated used as...
Galactosialidosis (GS) is a lysosomal storage disease linked to deficiency of the protective protein/cathepsin A (PPCA). Similarly GS patients, Ppca-null mice develop systemic reticuloendothelial system, affecting most visceral organs and nervous system. Symptoms include severe nephropathy, visceromegaly, infertility, progressive ataxia, shortened life span. Here, we have conducted preclinical, dose-finding study on large cohort injected intravenously at 1 month age with increasing doses...
A colistin-resistant Escherichia coli strain isolated from dog feces was characterized in this study.A multiplex PCR assay used to detect the presence of mcr genes; it found that E. QDFD216 co-harbored mcr-1 and mcr-3 genes. Whole-genome sequencing further bioinformatics analysis revealed belonged serotype O176:H11, fimH1311 type ST132. The resistance genes blaCTX-M-14, mdfA, dfrA3, acrA, acrB, tolc, sul3 were present chromosome. mcr-1.1 mcr-3.7 located two plasmids different incompatibility...
It is not clear which known adverse prognostic factors of neuroblastoma are closely associated with tumor recurrence after complete response. We analyzed the for post-remission in children through a retrospective study.A total 179 who achieved initial response were included this study. Kaplan-Meier method and multivariate Cox regression model used to assess that may have impact on response.The 5-year overall survival rates entire cohort (n = 179), group 86) non-recurrence 93) 81.9%, 66.2%,...
Balloon pulmonary angioplasty (BPA) is an established treatment for inoperable chronic thromboembolic hypertension (CTEPH), but its efficacy in CTEPH patients with a comorbidity has not been well-studied. Here, we compared post-BPA outcomes between and without disease at baseline analyzed predictors of BPA success. From August 2017 to October 2022, 62 who underwent were consecutively enrolled grouped based on the presence baseline. All transthoracic echocardiography, function tests, right...
The prognostic significance of microRNA (miR)-210 and the caspase 8-associated protein 2 (CASP8AP2) gene in children with acute lymphoblastic leukemia (ALL) has been validated CASP8AP2 demonstrated as a target miR-210. In present study, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to determine miR-210 expression 91 ALL. Associations between levels value combined detection two indicators were analyzed. Results from receiver operating characteristic curve...
Surgical treatment is mainly used for atlantoaxial tuberculosis with neurological damage. However, the anatomic structure around joint complex, and position of vertebral body deep, which increases difficulty operation it challenging surgeon to develop surgical strategy. The purpose this study was evaluate clinical outcomes one-stage combined anterior posterior approach impairment.From January 2005 2015, 12 patients suffering from impairment were surgically treated by approach. Preoperative...
The crisis of male infertility is an issue human reproductive health worldwide. Wuzi Yanzong pill (WZYZP) a traditional Chinese medicine prescription that shows efficacy in kidney reinforcement and essence benefit to ameliorate dysfunctions. However, the pharmacological mechanisms WZYZP on have not been investigated clarified clearly. This study was designed investigate effects spermatogenesis disorder explore its underlying mechanisms. First, based network pharmacology study, 39 bioactive...
We retrospectively investigated the role of neoadjuvant chemotherapy in low-risk patients with hepatoblastoma (HB) who underwent curative resection between February 2009 and December 2017. also verified feasibility risk stratification system to select optimal for upfront surgery.We compared 5-year overall survival (OS) event-free (EFS) surgery (n = 26) 104) groups at three oncology centers Beijing, China. To reduce effect covariate imbalance, propensity score matching (PSM) was used....
Background: Cardiotoxicity is one of the most serious chronic complications anthracyclines therapy. Assessment left ventricular ejection fraction (LVEF) fails to detect subtle cardiac dysfunction (LV). This study aimed and evaluate new parameters subclinical anthracyclines' cardiotoxicity in children with solid tumor. Methods: A detailed echocardiographic examination was performed 36 hepatoblastoma or rhabdomyosarcoma after receiving chemotherapy healthy controls from January 2015 December...