A5045051719- Renal and related cancers
- Renal cell carcinoma treatment
- Tissue Engineering and Regenerative Medicine
- Renal Diseases and Glomerulopathies
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- RNA modifications and cancer
- Biomedical Research and Pathophysiology
- Organ Donation and Transplantation
- Adolescent and Pediatric Healthcare
- RNA Research and Splicing
- Electromagnetic Fields and Biological Effects
- Diabetes and associated disorders
- Parathyroid Disorders and Treatments
- Spaceflight effects on biology
- Mesenchymal stem cell research
- Heat shock proteins research
- MicroRNA in disease regulation
- Immunodeficiency and Autoimmune Disorders
- Extracellular vesicles in disease
- Chronic Kidney Disease and Diabetes
University of Bari Aldo Moro
2022-2025
Abstract The rapidly developing field of renal spheroids and organoids has emerged as a valuable tool for modeling nephrotoxicity, kidney disorders, development. However, existing studies have relied on intricate sophisticated differentiation protocols to generate tubuloids, necessitating the external administration multiple growth factors within precise timeframes. In our study, we demonstrated that human adult progenitor cells (ARPCs) isolated from urine both healthy subjects patients can...
Pulsed electromagnetic fields (PEMF) are employed as a non-invasive medicinal therapy, especially in the orthopedic field to stimulate bone regeneration. However, effect of PEMF on skeletal muscle cells (SkMC) has been understudied. Here, we studied potentiality 1.5 mT early regeneration human SkMC. We showed that SkMC stimulated with for four hours repeated two days can cell proliferation without inducing apoptosis or significant impairment metabolic activity. Interestingly, when simulated...
Abstract The long non-coding RNAs (lncRNA) play an important role in several biological processes, including some renal diseases. Nevertheless, little is known about lncRNA that are expressed the healthy kidneys and involved cell homeostasis development, even less maintenance of human adult stem/progenitor cells (ARPCs) have been shown to be very for repair processes. Through a whole-genome transcriptome screening, we found HOTAIR highly progenitors potentially cycle senescence By...
Abstract Background and Aims Recent investigations have elucidated the complex system involving human adult renal stem/progenitor cells (ARPCs) their pivotal role in maintaining homeostasis facilitating regenerative processes within kidneys. CD133+/CD24+ ARPCs can repair several kinds of damage but reparative properties be compromised by cell senescence, contributing to aging impaired repair. The functional marker CD133 inversely correlates with cellular senescence plays a crucial ARPC...
Abstract Background and Aims Recent developments in stem cell biology have made it possible to create spheroids kidney organoids from human mouse pluripotent cells renal cells. Spheroids are a suitable vitro model for studies of drug can transform into whose rapidly developing field has proven useful simulating nephrotoxicity, disorders, development. However, date all the generation tubuloids required use sophisticated complex differentiation protocols involving external administration...
<title>Abstract</title> The rapidly developing field of renal spheroids and organoids has emerged as a valuable tool for modeling nephrotoxicity, kidney disorders, development. However, existing studies have relied on intricate sophisticated differentiation protocols to generate tubuloids, necessitating the external administration multiple growth factors within precise timeframes. In our study, we demonstrated that human adult progenitor cells (ARPCs) isolated from urine both healthy...
<title>Abstract</title> The rapidly developing field of renal spheroids and organoids has emerged as a valuable tool for modeling nephrotoxicity, kidney disorders, development. However, existing studies have relied on intricate sophisticated differentiation protocols to generate tubuloids, necessitating the external administration multiple growth factors within precise timeframes. In our study, we demonstrated that human adult progenitor cells (ARPCs) isolated from urine both healthy...
Abstract Background and Aims Organoids are self-organizing 3D aggregations of cells that represent the structure function organs. Kidney organoids have potential to advance field nephrology by providing a tool for study human kidney development disease, in vitro drug screening, ultimately, regenerative therapy. They can be derived from embryonic stem or induced pluripotent cells. We aimed explore first time, potentiality adult renal progenitor (ARPCs), isolated urine healthy subjects...
Abstract BACKGROUND AND AIMS Several models have been proposed to describe the pathogenesis of Immunoglobulin A nephropathy (IgAN) and, among them, multihit model where gut-microbiota may play an important role. These explain IgAN caused by production aberrant IgA, but it is believed that further predisposing factors are present, including immunological, genetic, environmental or nutritional factors. Recently, role IL-6 in becoming increasingly important. It essential for deposition...
Abstract BACKGROUND AND AIMS The complex system of human adult renal stem/progenitor cells (ARPCs) and their crucial role in the renewal epithelial regenerative processes kidneys have been recently discovered. In kidney, CD133+/CD24+ ARPCs are present within different segments nephron as a population with expansion, self-renewal differentiation capabilities. Understanding factors that regulate behaviour is fundamental to completely take advantage potential develop treatments for injury....