A5047242285- Mitochondrial Function and Pathology
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- ATP Synthase and ATPases Research
- Takotsubo Cardiomyopathy and Associated Phenomena
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neural Engineering
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Metabolism and Genetic Disorders
- Endoplasmic Reticulum Stress and Disease
- Cardiac Ischemia and Reperfusion
- Monoclonal and Polyclonal Antibodies Research
- Health and Lifestyle Studies
- Advanced Biosensing Techniques and Applications
- Inflammasome and immune disorders
Tecnológico de Monterrey
2015-2023
Background Traditional Body Mass Index based obesity classification presents limitations in pediatric populations, particularly among physically active children. The 2025 Obesity Classification Framework proposed by Lancet Diabetes & Endocrinology Commission integrates body fat distribution and metabolic biomarkers, aiming to enhance diagnostic accuracy obesity. Methods We evaluated 111 children (aged 5–11 years) from the Monterrey Football League Mexico using both traditional...
Pressure-overload (PO) causes cardiac hypertrophy (CH), and eventually leads to heart failure (HF). HF ventricular myocytes present transverse-tubules (TT) loss or disarrangement decreased sarcoplasmic reticulum (SR) density, both contribute altered Ca2+ signaling dysfunction. It has been shown that TT remodeling precedes HF, however, it is unknown whether SR structural functional also starts early in CH.Using confocal microscopy, we assessed (with Di-8-ANNEPS) SR-trapped Mag-Fluo-4)...
Patients with breast cancer (BC) overexpressing HER2 (HER2+) are selected for Trastuzumab treatment, which blocks and improves prognosis. However, HER2+ diagnosis, by the gold standard, immunohistochemistry, could lead to errors, associated to: a) variability in sample manipulation (thin 2D sections), b) use of subjective algorithms, c) heterogeneity expression within tissue. Therefore, we explored 3D detection multiplexed imaging Affibody-Quantum Dots conjugates (Aff-QD), ratiometric analysis (RMA
Mitochondria modify their function and morphology to satisfy the bioenergetic demand of cells. Cancer cells take advantage these features sustain metabolic, proliferative, metastatic, survival necessities. Understanding morphological changes mitochondria in different grades triple-negative breast cancer (TNBC) could help design new treatments. Consequently, this research explored mitochondrial gene expression some proteins related dynamics, as well associated with oxidative non-oxidative...
The mitochondrion is an organelle that can be elongated, fragmented, and renovated according to the metabolic requirements of cells. remodeling mitochondrial network allows healthy mitochondria meet cellular demands; however, loss this capacity has been related development or progression different pathologies. In skeletal muscle, density distribution changes are observed in physiological pathological conditions such as exercise, aging, obesity, among others. Therefore, study may provide a...
The mitochondrion is an organelle that can be elongated, fragmented, and renovated according to the metabolic requirements of cells. remodeling mitochondrial network allows healthy mitochondria meet cellular demands; however, loss this capacity has been related development or progression different pathologies. In skeletal muscle, density distribution changes are observed in physiological pathological conditions such as exercise, aging, obesity, among others. Therefore, study may provide a...
Abstract Background: Triple negative breast cancer (TNBC) is characterized by heterogeneous metastatic and metabolic properties, which difficult the diagnosis development of specific treatment. Therefore, understanding mitochondria´s role in different grades TNBC could be relevant for design novel treatments. This research aimed to explore mitochondria morphology gene expression proteins related oxidative non-oxidative metabolism non-metastatic cell lines. Methods: We performed a analysis...