A5039193721- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Insect Pest Control Strategies
- Data-Driven Disease Surveillance
- Pharmacogenetics and Drug Metabolism
- Toxin Mechanisms and Immunotoxins
- Nuclear Receptors and Signaling
- Berberine and alkaloids research
- HIV/AIDS oral health manifestations
- Research on Leishmaniasis Studies
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- GDF15 and Related Biomarkers
- Natural product bioactivities and synthesis
- FOXO transcription factor regulation
- Aquaculture disease management and microbiota
Centre de Recherche en Cancérologie de Toulouse
2023
Inserm
2023
Université Toulouse III - Paul Sabatier
2023
Centre National de la Recherche Scientifique
2023
Institut universitaire du cancer de Toulouse Oncopole
2023
Universidade Federal do Pará
2021-2023
Gastric cancer is among the major causes of death from neoplasia leading worldwide, with high incidence rates and problems related to its treatment. Here, we outline how Geissospermum sericeum exerts antitumor activity on ACP02 cell line (human gastric adenocarcinoma) mechanism death. The ethanol extract fractions, neutral fraction alkaloid fraction, were characterized by thin-layer chromatography HPLC-DAD, yielding an (geissoschizoline N4-methylchlorine) identified NMR. cytotoxicity samples...
GSCs play an important role in GBM recurrence. Understanding the resistance mechanisms these cells is therefore crucial for radiation therapy optimization. In this study, using patient-derived GSCs, we demonstrate that GDF15, a cytokine belonging to TGF-β superfamily, regulated by irradiation (IR) and transcription factor WWTR1/TAZ. Blocking WWTR1/TAZ specific siRNAs significantly reduces GDF15 basal expression reverses upregulation of induced IR. Furthermore, plays GSC radioresistance....
This study aimed to evaluate the anti-leishmania activity of extracts and fractions from stem leaf Montrichardia linifera against Leishmania amazonensis. The (EES) (EEL) were obtained by maceration powders with 96º GL alcohol. subjected exhaustive extraction using a reflux system solvents increasing polarity, obtaining 4 for each extract: hexane, dichloromethane, ethyl acetate methanol. submitted phytochemical prospecting study. antipromastigote cytotoxicity in macrophages (J774) performed...
the Italian National HIV Surveillance, instituted by Ministerial Decree of March 31st, 2008, is based on 21 regional surveillance systems and adopts an essential data collection form with a definite flow. The unification AIDS implementation identical are priorities HIV/AIDS Action Plan 2017 (PNAIDS).to describe to verify feasibility their unification.in 2017, questionnaire containing 13 questions was sent all representatives systems. main were about timeliness, flow, quality system. measured...
O presente estudo objetivou caracterizar o perfil clinico-epidemiológico de pessoas vivendo com HIV (PVHIV) residentes no estado do Pará. Foram incluídos todos os indivíduos, independente idade ou sexo, cujas amostras, 2013 a 2015, foram encaminhadas ao Laboratório Central Pará (LACEN-PA) para realização teste genotipagem HIV. Os dados obtidos por meio da coleta informações nos laudos guardados LACEN. coletadas como idade, nível escolaridade, raça, ano diagnóstico, motivos relacionados...
Objetivo: Caracterizar o perfil de miRNAs virais, seus mecanismos patogênese e descrever sua interação com hospedeiro. Métodos: Essa pesquisa é uma revisão integrativa, as palavras-chaves foram padronizadas acordo os Descritores em Ciências da Saúde (DeCS), bases dados consultadas NCBI, LILACS, BVS SciELO. Resultados: Os regulam negativamente a sinalização IFNγ, RIGI, suprimindo resposta imune inata, funcionam como imunomoduladores também sendo regulados positivamente várias vias PI3K/Akt...