A5036585007- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Vascular Malformations Diagnosis and Treatment
- Ophthalmology and Visual Impairment Studies
- Ocular Diseases and Behçet’s Syndrome
- Intracranial Aneurysms: Treatment and Complications
- Corneal surgery and disorders
- Ocular Oncology and Treatments
- Ocular Surface and Contact Lens
- Ocular Disorders and Treatments
- Retinopathy of Prematurity Studies
- Cerebral Venous Sinus Thrombosis
- Drug-Induced Ocular Toxicity
- Ophthalmology and Eye Disorders
- Corneal Surgery and Treatments
- Connexins and lens biology
- Ocular Infections and Treatments
- Virus-based gene therapy research
- Diversity and Career in Medicine
- COVID-19 and healthcare impacts
Columbia University
2014-2023
NewYork–Presbyterian Hospital
1996-2023
Columbia University Irving Medical Center
2013-2023
Insall Scott Kelly Institute
1997-2022
Boehringer Ingelheim (Taiwan)
2022
Cornell University
1984-2021
New York Hospital Queens
2009-2021
Columbia College
2021
New York Proton Center
2018
Prevent Blindness
2006-2016
Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in elderly developed countries. Our previous studies implicated activation complement formation drusen, hallmark lesion AMD. Here, we show that factor H (HF1), major inhibitor alternative pathway, accumulates within drusen and synthesized by retinal pigmented epithelium. Because linkage analyses identified chromosome 1q25-32, which harbors gene ( HF1 / CFH ), as an AMD susceptibility locus, analyzed...
Angiogenesis underlies the majority of eye diseases that result in catastrophic loss vision. Recent evidence has implicated integrins alpha v beta 3 and 5 angiogenic process. We examined expression neovascular ocular tissue from patients with subretinal neovascularization age-related macular degeneration or presumed histoplasmosis syndrome retinal proliferative diabetic retinopathy (PDR). Only was observed on blood vessels tissues active histoplasmosis, whereas both were present vascular...
To improve the understanding of Stargardt disease by comparing structural changes seen on spectral domain optical coherence tomography (SD-OCT) to those visible fundus autofluorescence (FAF).
Central serous chorioretinopathy (CSC) is characterized by leakage of fluid from the choroid into subretinal space and, consequently, loss central vision. The disease triggered endogenous and exogenous corticosteroid imbalance psychosocial stress much more prevalent in men. We studied association genetic variation 44 genes response metabolism pathways with CSC phenotype two independent cohorts 400 cases 1,400 matched controls. expression cadherin 5 (CDH5), major cell-cell adhesion molecule...
Purpose.: To compare choroidal thickness (CT) measurements in early AMD between patients with and without reticular pseudodrusen (RPD) using spectral-domain optical coherence tomography (SD-OCT). Methods.: This cross-sectional study examined 84 age- sex-matched (40 RPD [63 eyes], 44 non-RPD [75 eyes]). Fundus photographs scanning laser ophthalmoscopy images were graded to identify groups by three retinal specialists (MO, SY, SB) who masked corresponding SD-OCTs. CT at the fovea 2400 3000 μm...
To estimate the incidence of and identify risk factors for late-onset open-angle glaucoma (OAG) after uncomplicated pars plana vitrectomy (PPV).All patients who underwent PPV at Edward Harkness Eye Institute between January 1998 2004 had least 6 months follow-up did not have preexisting or reason secondary development were included. Retrospective cohort matched case-control study designs used.Of 285 vitrectomized eyes that met enrollment criteria, 11.6% (n = 33) developed vitrectomy. In...
The temporary cessation and profound changes in ophthalmic care delivery that occurred as a result of the coronavirus disease 2019 (COVID-19) pandemic have yet to be fully understood. Our objective is assess patients' self-reported impact health lockdown measures on their fears anxieties during crisis period COVID-19 New York City.We conducted digital, self-reported, patient survey distributed by an e-mail at Columbia University's Department Ophthalmology outpatient faculty practice....
OBP-301 is an oncolytic adenovirus modified to replicate within cancer cells and lyse them. This open-label, non-comparative, phase I dose-escalation trial aimed assess its safety optimal dosage in 20 patients with advanced hepatocellular carcinoma. Good tolerance was shown a maximum tolerated dose of 6 × 1012 viral particles. The most common treatment-emergent adverse events were influenza-like illness, pyrexia, fatigue, decreased platelet count, abdominal distension, anemia. Cohorts 4 5...
It has been suggested that lipofuscin accumulation, as measured by increased fundus autofluorescence (FAF), precedes progression or development of junctional zone geographic atrophy (GA) in age-related macular degeneration (AMD). The tools biomedical image analysis were used to measure the probabilistic relationship GA FAF.Serial AF images eight eyes six patients with AMD registered on computer. leveled a 12-zone quadratic polynomial mathematical model minimize background variability....
Pseudoxanthoma elasticum is a disorder of connective tissue that associated with numerous systemic complications, including accelerated atherosclerosis, gastrointestinal bleeding, angioid streaks in the ocular fundus, and blindness. Diagnosis disease important because many its complications can be prevented genetic counseling offered to family members affected patients. The purpose this study was examine usefulness scar biopsy establishing diagnosis pseudoxanthoma patients but without...
This paper addresses the design considerations and dexterity evaluation of a novel hybrid two-armed micro-surgical slave robot equipped with intraocular devices. A unified framework for kinematic modeling this is presented while using constraints stemming from constrained motion eye. An augmented Jacobian describing kinematics eye relative each one two robots (IODR) presented. Using framework, capabilities in performing dexterous operations are evaluated compared to similar without...