A5076237848- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- NF-κB Signaling Pathways
- Liver Disease and Transplantation
- Microtubule and mitosis dynamics
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- ATP Synthase and ATPases Research
Sun Yat-sen University
2019-2024
State Key Laboratory of Oncology in South China
2022
Sun Yat-sen University Cancer Center
2019-2022
Background and Aims DNA damage‐induced NF‐κB activation is a major obstacle to effective antitumour chemotherapy. Long noncoding RNAs (lncRNAs) that regulate chemoresistance of cancer cells remain largely unknown. This study aimed characterize the lncRNAs may affect chemotherapy sensitivity. Approach Results We found lncRNA PDIA3P1 (protein disulfide isomerase family A member 3 pseudogene 1) was up‐regulated in multiple types following treatment with DNA‐damaging chemotherapeutic agents,...
Although thousands of long noncoding RNAs (lncRNAs) have been annotated, only a limited number them functionally characterized. Here, we identified an oncogenic lncRNA, named lnc‐UCID ( lnc RNA u p‐regulating C DK6 by i nteracting with D HX9). Lnc‐UCID was up‐regulated in hepatocellular carcinoma (HCC), and higher level correlated shorter recurrence‐free survival HCC patients. Both gain‐of‐function loss‐of function studies revealed that enhanced cyclin‐dependent kinase 6 (CDK6) expression...
Abstract Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether pyroptosis can be death form of MC remains unknown. Proteasome-mediated protein degradation is crucial for M-phase. Bortezomib (BTZ), inhibits the 20S catalytic particle proteasome, approved treat multiple myeloma and mantle cell lymphoma, but not solid tumors due primary resistance. To date, whether how proteasome inhibitor affected fates...
Abstract Oncogenic c-Myc is a master regulator of G1/S transition. Long non-coding RNAs (lncRNAs) emerge as new regulators various cell activities. Here, we found that lncRNA SnoRNA Host Gene 17 (SNHG17) was elevated at the early G1-phase cycle. Both gain- and loss-of function studies disclosed SNHG17 increased protein level, accelerated transition proliferation, consequently promoted tumor growth in vitro vivo. Mechanistically, 1-150-nt physically interacted with 1035-1369-aa leucine rich...
To investigate the role of human serum albumin (hsa)_circular (circ)_0000711 in hepatocellular carcinoma (HCC). Circular ribonucleic acids (circRNAs) are proven numerous studies to play crucial tumor biology, but their roles HCC remain unknown a great extent.The circRNA expression profile microarray was employed screen differentially expressed circRNAs tissues and adjacent from patients, Reverse Transcription-quantitative Polymerase Chain Reaction (RT-qPCR) assay performed for further...