A5007536349- Nerve injury and regeneration
- Spinal Cord Injury Research
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Advanced Breast Cancer Therapies
- Adipose Tissue and Metabolism
- Protease and Inhibitor Mechanisms
- Cancer Treatment and Pharmacology
- Regulation of Appetite and Obesity
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Cancer-related gene regulation
- Anesthesia and Pain Management
- Cellular Mechanics and Interactions
- Pediatric Pain Management Techniques
- Nerve Injury and Rehabilitation
- Hernia repair and management
- Receptor Mechanisms and Signaling
- Cardiac Arrest and Resuscitation
- Spine and Intervertebral Disc Pathology
- Breast Cancer Treatment Studies
- Electrospun Nanofibers in Biomedical Applications
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
Servicio de Salud de Castilla La Mancha
2024
Hospital Nacional de Parapléjicos
2011-2024
USP Institut Universitari Dexeus
2009
Centro de Investigaciones Biológicas Margarita Salas
2003-2008
Consejo Superior de Investigaciones Científicas
2003
Background Spinal cord injury is a major cause of disability that has no clinically accepted treatment. Functional decline following spinal caused by mechanical damage, secondary cell death, reactive gliosis and poor regenerative capacity damaged axons. Wnt proteins are family secreted glycoproteins play key roles in different developmental processes although little known the expression patterns functions Wnts adult central nervous system normal or diseased states. Findings Using qRT-PCR...
We have studied the function of Hep III fibronectin domain in cytoskeletal response initiated by alpha5beta1 integrin-mediated adhesion. Melanoma cells formed stress fibers and focal adhesions on RGD-containing FNIII7–10 fragment. Coimmobilization FNIII4–5, a fragment spanning containing alpha4beta1 ligand H2 with FNIII7–10, or addition soluble FNIII4–5 to preattached inhibited induced cytoplasmic protrusions. This effect involved since: 1) mutations reverted inhibition; 2) other ligands...
Imaging mass spectrometry (IMS) is quickly becoming a technique of reference to visualize the lipid distribution in tissue sections. Still, many questions remain open, and data analysis has be optimized avoid interpretation pitfalls. Here we analyze how variation on [Na+]/[K+] relative abundance affects detection lipids between sections spinal cord (uninjured) control rats models demyelination traumatic contusion injury. The [M + Na]+/[M K]+ adducts ratio remained approximately constant...
Cell adhesion to fibronectin results in formation of actin stress fibres and focal adhesions. In fibroblasts, this response requires two co-operative signals provided by interactions the RGD sequence with alpha5beta1 integrin heparin-binding domain II (Hep II) syndecan-4. Within Hep II, activity was mapped repeat III13 peptide FN-C/H-V(WQPPRARITGY, III14). We previously described that synthetic peptide/III5 (HBP/III5) (WTPPRAQITGYRLTVGLTRR, III5) binds heparin mediates cell via chondroitin...
Abstract α4β1 integrin is highly expressed in lymphocytes and essential hematopoiesis, extravasation, the inflammatory response. can be activated by intracellular signals elicited upon T‐cell activation phorbol esters, CD3 crosslinking, or certain chemokine/receptor interactions (inside‐out activation). Divalent cations anti‐ β1 mAbs (i.e., TS2/16) also bind activate integrins directly (outside‐in In both cases, results increased adhesion and/or affinity for ligands. It not known if these...
Mounting experimental evidence has underscored the remarkable role played by Wnt family of proteins in spinal cord functioning and therapeutic potential injury (SCI). We aim to provide a prospect associated with modulation canonical signaling, examining spatio-temporal expression pattern Dickkopf-1 (Dkk1) its neutralization after SCI. employ an intraparenchymal injection clinically validated Dkk1-blocking antibody, BHQ880, elucidate effects
Spinal cord injury (SCI) is a devastating event with huge personal and social costs, for which there no effective treatment. Cell therapy constitutes promising therapeutic approach SCI; however, its clinical potential seriously limited by their low survival in the hostile conditions encompassing acute phase of SCI. Human HC016 (hHC016) cells, generated from expanded human adipose mesenchymal stem cells (hAMSCs) pulsed patented protocol hydrogen peroxide (H2O2), are expected to acquire...
Despite the promising potential of hydrogel-based therapeutic approaches for spinal cord injury (SCI), need new biomaterials to design effective strategies SCI treatment and outstanding properties silk-elastin-like polymers (SELP), use SELPs in is currently unknown. In this context, we assessed effects elicited by vivo acute intraparenchymal injection an SELP named (EIS)2-RGD6 a clinically relevant model SCI. After optimization system, distribution, structure, biodegradability, cell...
There has been progress in the identification of factors that confer important risk for development breast cancer.The include: heritable mutations susceptibility genes; exposure to therapeutic radiation during (as Hodgkin's disease survivors who received chest); and histologic lesions, including LCIS atypical hyperplasias.Testing BRCA1 BRCA2 ovarian cancer genes become part established care patients.Genetic information from BRCA1/2 testing is used help healthy at-risk women avoid and/or...