Carlos González‐Fernández
A5101967270- Nerve injury and regeneration
- Wnt/β-catenin signaling in development and cancer
- Spinal Cord Injury Research
- Cancer-related gene regulation
- Astrophysics and Star Formation Studies
- Cancer Genomics and Diagnostics
- Health, Environment, Cognitive Aging
- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- Amyotrophic Lateral Sclerosis Research
- Stellar, planetary, and galactic studies
- Neuropeptides and Animal Physiology
- Autoimmune Neurological Disorders and Treatments
- Anesthesia and Pain Management
- Adipose Tissue and Metabolism
- Scientific Computing and Data Management
- Pediatric Pain Management Techniques
- Delphi Technique in Research
- Nerve Injury and Rehabilitation
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Evolution and Genetic Dynamics
- Shoulder Injury and Treatment
- Advanced Fluorescence Microscopy Techniques
- Osteoarthritis Treatment and Mechanisms
Althaia
2024
Hospital Nacional de Parapléjicos
2011-2024
University of Cambridge
2016-2023
Universidad Nacional Experimental Simón Rodríguez
2020
Servicio de Salud de Castilla La Mancha
2016
Summary: The Imaging and Molecular Annotation of Xenografts Tumors Cancer Grand Challenges team was set up with the objective developing “next generation” pathology cancer research by using a combination single-cell spatial omics tools to produce 3D molecularly annotated maps tumors. Its activities overlapped, in some cases catalyzed, revolution biology that saw new technologies being deployed investigate roles tumor heterogeneity micro-environment. See related article Stratton et al., p. 22...
Background Spinal cord injury is a major cause of disability that has no clinically accepted treatment. Functional decline following spinal caused by mechanical damage, secondary cell death, reactive gliosis and poor regenerative capacity damaged axons. Wnt proteins are family secreted glycoproteins play key roles in different developmental processes although little known the expression patterns functions Wnts adult central nervous system normal or diseased states. Findings Using qRT-PCR...
The Wnt family of proteins plays key roles during central nervous system development and has been involved in several neuropathologies adulthood, including spinal cord injury (SCI). However, Wnts expression knowledge is relatively limited adult stages. Here, we sought to define the pattern after SCI mice by using quantitative polymerase chain reaction (qPCR) immunohistochemistry (IHC). Under physiological conditions, messenger RNAs (mRNAs) most ligands, inhibitors, receptors, coreceptors are...
NGC 6067 is a young open cluster hosting the largest population of evolved stars among known Milky Way clusters in 50-150 Ma age range. It thus represents best laboratory our Galaxy to constrain evolutionary tracks 5-7 M$_{\odot}$ stars. We have used high-resolution spectra large sample bright members (45), combined with archival photometry, obtain accurate parameters for as well stellar atmospheric parameters. derive distance 1.78$\pm$0.12 kpc, an 90$\pm$20 and tidal radius...
<p>IMAXT Consortium Author List</p>
<div>Summary:<p>The Imaging and Molecular Annotation of Xenografts Tumors Cancer Grand Challenges team was set up with the objective developing “next generation” pathology cancer research by using a combination single-cell spatial omics tools to produce 3D molecularly annotated maps tumors. Its activities overlapped, in some cases catalyzed, revolution biology that saw new technologies being deployed investigate roles tumor heterogeneity micro-environment.</p><p><a...
<p>IMAXT Consortium Author List</p>
Wnt proteins are a large family of molecules that critically involved in multiple central nervous system (CNS) developmental processes. Experimental evidences suggest role for this many CNS disorders, including spinal cord injury (SCI), which is major neuropathology owing to its high prevalence and chronic sensorimotor functional sequelae. Interestingly, most their inhibitors expressed the uninjured cord, temporal expression patterns dramatically altered after injury. However, little known...
It is well known that inflammation crucial in the onset and progression of neurodegenerative diseases traumatic central nervous system (CNS) injuries, microglia monocyte-derived macrophages (MDMs) play a pivotal role neuroinflammation. Therefore, exploration molecular signaling pathways are involved microglia/macrophage response might help us to shed light on their eventual therapeutic modulation. Interestingly, there growing evidence showing Wnt family proteins different neuropathologies...
Amyotrophic lateral sclerosis is a chronic neurodegenerative disease characterized by progressive paralysis due to degeneration of motor neurons unknown causes. Recent evidence shows that Wnt signaling involved in processes, including Lateral Sclerosis. However, date, little known regarding the expression components this fatal condition. In present study we used transgenic SOD1G93A mice evaluate several components, with special focus on Frizzled-5 cellular alteration along progression.Based...
ABSTRACT Average stellar orbits of the Galactic disk may have some small intrinsic ellipticity which breaks exact axisymmetry and there also be migration stars inwards or outwards. Both phenomena can detected through kinematic analyses. We use red clump selected spectroscopically from APO Evolution Experiment, with known distances radial velocities, to measure component Galactocentric velocities within 5 kpc < R 16 kpc, <?CDATA $| b| \lt 5^\circ $?> , 20° Sun–Galactic center line. The...
We present an atlas composed of more than 1500 spectra late-type stars (spectral types from G to M) observed simultaneously in the optical and calcium triplet spectral ranges. These were obtained as part a survey search for cool supergiants Magellanic Clouds taken over four epochs. provide luminosity classification each spectrum (71% are supergiants, 13% giants or luminous giants, 4% carbon S stars, remaining 12% foreground lesser luminosities). also detailed guide result extensive work done...
With the aim of producing a 3D representation tumors, imaging and molecular annotation xenografts tumors (IMAXT) uses large variety modalities in order to acquire tumor samples produce map every cell its host environment. volume data produced project, we developed automatic workflows analysis pipelines. We introduce research methodology where scientists connect cloud environment perform close are located, instead bringing their local computers. Here, present infrastructure, discuss unique...
Abstract Accordingly to its known function in corticospinal tract (CST) developmental growth, previous reports have shown an inhibitory role of Wnt5a CST regeneration after spinal cord injury (SCI). Interestingly, it has been subsequently demonstrated that also modulates the growth non‐CST axons and different receptors are expressed neurons, oligodendrocytes, NG2+ glial precursors reactive microglia/macrophages astrocytes SCI. However, response these cell types, functional recovery SCI is...
Despite the promising potential of hydrogel-based therapeutic approaches for spinal cord injury (SCI), need new biomaterials to design effective strategies SCI treatment and outstanding properties silk-elastin-like polymers (SELP), use SELPs in is currently unknown. In this context, we assessed effects elicited by vivo acute intraparenchymal injection an SELP named (EIS)2-RGD6 a clinically relevant model SCI. After optimization system, distribution, structure, biodegradability, cell...
Mounting experimental evidence has underscored the remarkable role played by Wnt family of proteins in spinal cord functioning and therapeutic potential injury (SCI). We aim to provide a prospect associated with modulation canonical signaling, examining spatio-temporal expression pattern Dickkopf-1 (Dkk1) its neutralization after SCI. employ an intraparenchymal injection clinically validated Dkk1-blocking antibody, BHQ880, elucidate effects
Abstract With the aim of producing a 3D representation tumours, IMAXT uses large variety modalities in order to acquire tumour samples and produce map every cell its host environment. volume data produced project we develop automatic workflows analysis pipelines introduce research methodology where scientists connect cloud environment perform close are located instead bringing their local computers. Here present infrastructure, discuss unique computational challenges describe chains...