A5088186669- Vitamin D Research Studies
- Diet and metabolism studies
- Diabetes Management and Research
- Vitamin C and Antioxidants Research
- Nutritional Studies and Diet
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bone health and osteoporosis research
- Eating Disorders and Behaviors
- Obesity, Physical Activity, Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacology and Obesity Treatment
- Obesity and Health Practices
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Education
- Dietary Effects on Health
- Diabetes and associated disorders
- Regulation of Appetite and Obesity
- Chronic Disease Management Strategies
- Thyroid Cancer Diagnosis and Treatment
- Mobile Health and mHealth Applications
- Physical Activity and Health
- Cancer Risks and Factors
- Healthcare cost, quality, practices
Tufts Medical Center
2016-2025
Maine Medical Center
2022
Towson University
2022
Providence College
2021
King Faisal Specialist Hospital & Research Centre
2017
Tufts University
2004-2016
Diabetes Australia
2003-2016
Jean Mayer Human Nutrition Research Center on Aging
2004-2015
Brown University
2015
University of Wisconsin–Madison
2015
OBJECTIVE—The purpose of this study was to prospectively examine the association between vitamin D and calcium intake risk type 2 diabetes. RESEARCH DESIGN AND METHODS—In Nurses’ Health Study, we followed 83,779 women who had no history diabetes, cardiovascular disease, or cancer at baseline for development Vitamin from diet supplements assessed every 2–4 years. During 20 years follow-up, documented 4,843 incident cases RESULTS—After adjusting multiple potential confounders, there total...
We sought to compare the effects of combined calcium and vitamin D supplementation versus placebo on blood glucose markers inflammation in nondiabetic adults aged > or =65 years.A total 314 Caucasian without diabetes received either 500 mg citrate 700 IU D(3) placebos daily for 3 years a double-blind, randomized, controlled trial designed bone-related outcomes. In post hoc analysis, fasting plasma (FPG), insulin sensitivity (estimated by homeostasis model assessment resistance [HOMA-IR]),...
Observational studies support an association between a low blood 25-hydroxyvitamin D level and the risk of type 2 diabetes. However, whether vitamin supplementation lowers diabetes is unknown.We randomly assigned adults who met at least two three glycemic criteria for prediabetes (fasting plasma glucose level, 100 to 125 mg per deciliter; hours after 75-g oral load, 140 199 glycated hemoglobin 5.7 6.4%) no diagnostic receive 4000 IU day D3 or placebo, regardless baseline serum level. The...
To determine whether neurodegeneration in Alzheimer disease brain is associated with degradation of structural cell membrane molecules, we measured tissue levels the major phospholipids and their metabolites three cortical areas from postmortem brains patients matched controls. Among phospholipids, there was a significant (P less than 0.05) decrease phosphatidylcholine phosphatidylethanolamine. There were decreases initial phospholipid precursors choline ethanolamine increases deacylation...
Osteocalcin has been reported to contribute the regulation of glucose tolerance and insulin secretion sensitivity in experimental animals.Our objective was examine association between serum osteocalcin concentration markers dysmetabolic phenotype using data from a completed clinical trial adults age 65 older [n = 380, mean 71 yr, body mass index (BMI) 26.9 kg/m(2), 5% with diabetes].In cross-sectional analyses (baseline data), we estimated associations urine N-telopeptide metabolic including...
In recent years, vitamin D has been received increased attention due to the resurgence of deficiency and rickets in developed countries identification extraskeletal effects D, suggesting unexpected benefits health disease, beyond bone health. The possibility was first noted with discovery receptor (VDR) tissues cells that are not involved maintaining mineral homeostasis health, including skin, placenta, pancreas, breast, prostate colon cancer cells, activated T cells. However, biological...
Calorie restriction (CR) increases longevity in many species and reduces risk factors for chronic diseases. In humans, CR may improve health span, yet concerns remain about potential negative effects of CR.To test the effect on mood, quality life (QOL), sleep, sexual function healthy nonobese adults.A multisite randomized clinical trial (Comprehensive Assessment Long-term Effects Reducing Intake Energy Phase 2 [CALERIE 2]) was conducted at 3 academic research institutions. Adult men women (N...
OBJECTIVE Postrandomization biases may influence the estimate of efficacy supplemental vitamin D in diabetes prevention trials. In Vitamin and Type 2 Diabetes (D2d) study, repeated measures serum 25-hydroxyvitamin [25(OH)D] level provided an opportunity to test whether intratrial exposure affected risk effect was modified by trial assignment (vitamin vs. placebo). RESEARCH DESIGN AND METHODS The D2d study compared daily supplementation with 100 μg (4,000 units) D3 versus placebo on new-onset...
Abstract Background Numerous studies demonstrate associations between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and a variety common disorders, including musculoskeletal, metabolic, cardiovascular, malignant, autoimmune, infectious diseases. Although causal link 25(OH)D many disorders has not been clearly established, these have led to widespread supplementation with vitamin increased laboratory testing for in the general population. The benefit-risk ratio this increase use is...