A5080336518- Estrogen and related hormone effects
- Oral Health Pathology and Treatment
- Endometrial and Cervical Cancer Treatments
- Hidradenitis Suppurativa and Treatments
- 14-3-3 protein interactions
- Renal cell carcinoma treatment
- Colorectal and Anal Carcinomas
- Cancer, Lipids, and Metabolism
- Protein Degradation and Inhibitors
- Cancer Genomics and Diagnostics
- Inflammatory mediators and NSAID effects
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- CRISPR and Genetic Engineering
- Cancer Research and Treatments
- Melanoma and MAPK Pathways
- Peroxisome Proliferator-Activated Receptors
- Cancer Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Computational Drug Discovery Methods
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Extracellular vesicles in disease
University of Utah
2012-2025
Huntsman Cancer Institute
2016-2025
Brigham Young University
2020
Oklahoma Medical Research Foundation
2016
Division of Chemistry
2013
University of California, San Francisco
2005-2012
Pennsylvania State University
2012
UCSF Helen Diller Family Comprehensive Cancer Center
2005
University of Toronto
2000
Simon Fraser University
1997
microRNAs are promising candidate breast cancer biomarkers due to their cancer-specific expression profiles. However, efforts develop circulating challenged by the heterogeneity of in blood. To overcome this challenge, we aimed a molecular profile specifically secreted from cells. Our first step towards direction relates capturing and analyzing contents exosomes, which small secretory vesicles that selectively encapsulate indicative cell origin. our knowledge, exosome have not been...
Models that recapitulate the complexity of human tumors are urgently needed to develop more effective cancer therapies. We report a bank patient-derived xenografts (PDXs) and matched organoid cultures from represent greatest unmet need: endocrine-resistant, treatment-refractory metastatic breast cancers. leverage PDXs PDX-derived organoids (PDxO) for drug screening is feasible cost-effective with in vivo validation. Moreover, we demonstrate feasibility using these models precision oncology...
Abstract Non-classical secretory vesicles, collectively referred to as extracellular vesicles (EVs), have been implicated in different aspects of cancer cell survival and metastasis. Here, we describe how a specific class EVs, called microvesicles (MVs), activates VEGF receptors tumour angiogenesis through unique 90 kDa form (VEGF 90K ). We show that is generated by the crosslinking 165 , catalysed enzyme tissue transglutaminase, associates with MVs its interaction chaperone Hsp90. further...
Small-cell lung cancer (SCLC) has been treated clinically as a homogeneous disease, but recent discoveries suggest that SCLC is heterogeneous. Whether metabolic differences exist among subtypes largely unexplored. In this study, we aimed to determine whether vulnerabilities between can be therapeutically exploited.We performed steady state metabolomics on tumors isolated from distinct genetically engineered mouse models (GEMM) representing the MYC- and MYCL-driven of SCLC. Using genetic...
In the nematode Caenorhabditis elegans, zinc finger transcriptional regulator TRA-1A directs XX somatic cells to adopt female fates. The membrane protein TRA-2A indirectly activates by binding and inhibiting a masculinizing protein, FEM-3. Here we report that part of intracellular domain TRA-2A, distinct from FEM-3 region, directly binds TRA-1A. Overproduction this TRA-1A-binding region has tra-1-dependent feminizing activity in tissues, indicating interaction enhances activity. Consistent...
Sulf-2 is an endosulfatase with activity against glucosamine-6-sulfate modifications within subregions of intact heparin. The enzyme has the potential to modify sulfation status extracellular heparan sulfate proteoglycan (HSPG) glycosaminoglycan chains and thereby regulate interactions HSPG-binding proteins. In present investigation, data mining from published studies was employed establish mRNA upregulation in human breast cancer. We further found that cultured carcinoma cells expressed...
Glioblastoma (GBM), a uniformly lethal brain cancer, is characterized by diffuse invasion and abnormal activation of multiple receptor tyrosine kinase (RTK) signaling pathways, presenting major challenge to effective therapy. The many RTK pathways regulated extracellular heparan sulfate proteoglycans (HSPG), suggesting these molecules may be targets in the tumor microenvironment. In this study, we demonstrated that sulfatase, SULF2, an enzyme regulates HSPG-dependent was expressed primary...
Abstract Purpose: Triple-negative breast cancer (TNBC) lacks an approved targeted therapy. Despite initial good response to chemotherapy, 30% of the patients relapse within 5 years after treatment. EGFR overexpression is a common marker in TNBC, and its expression has been correlated with poor outcome. Inhibition fatty acid synthase (FASN) activity leads apoptosis human carcinoma cells overexpressing FASN. We tested hypothesis that blocking FASN combination anti-EGFR signaling agents would...
Acquired resistance to trastuzumab is a major clinical problem in the treatment of HER2-positive (HER2+) breast cancer patients. The selection trastuzumab-resistant patients great challenge precision oncology. aim this study was identify novel epigenetic biomarkers associated HER2+ BC patients.We performed genome-wide DNA methylation (450K array) and transcriptomic analysis (RNA-Seq) comparing trastuzumab-sensitive (SK) (SKTR) human cell models. expression levels candidate genes were...
Heparan sulfate (HS) chains are found in the extracellular matrix, covalently linked to core proteins collectively termed heparan proteoglycans (HSPGs). A wealth of data has demonstrated roles for HSPGs regulation many cell surface signaling pathways that crucial during development. Variations sulfation pattern along HS influence their ability interact with molecules such as growth factors, chemokines, morphogens, and adhesion molecules. Sulf1 Sulf2 members a class recently identified genes...
There are conflicting epidemiologic data on whether chronic aspirin (ASA) use may reduce melanoma risk in humans. Potential anticancer effects of ASA be mediated by its ability to suppress prostaglandin E2 (PGE2) production and activate 5'-adenosine monophosphate-activated protein kinase (AMPK). We investigated the inhibitory a panel transformed melanocyte cell lines, tumor growth preclinical model. COX-2 inhibitor celecoxib did not affect viability, but significantly reduced colony...
Benign melanocytic nevi frequently emerge when an acquired BRAF V600E mutation triggers unchecked proliferation and subsequent arrest in melanocytes. Recent observations have challenged the role of oncogene-induced senescence nevus formation, necessitating investigations into alternative mechanisms for establishment maintenance nevi. We compared transcriptomes melanocytes from healthy human skin, nevi, melanomas arising identified a set microRNAs as highly expressed nevus-enriched...
<p>Supplemental Figure and Legend 1</p>
<p>Supplemental Table 2: Secretome proteomics</p>
<p>Supplemental Figure and Legend 6</p>
<p>Supplemental Figure and Legend 3</p>
<p>Supplemental Figure and Legend 5</p>
<p>Supplemental Figure and Legend 2</p>
<p>Supplemental Table 1: Primers used</p>
<p>Additional Materials and Methods</p>
<p>Supplemental Figure and Legend 4</p>