A5058952306- Cutaneous Melanoma Detection and Management
- melanin and skin pigmentation
- Cutaneous lymphoproliferative disorders research
- Nonmelanoma Skin Cancer Studies
- Skin Protection and Aging
- Cancer and Skin Lesions
- Immunotherapy and Immune Responses
- Melanoma and MAPK Pathways
- Cancer Genomics and Diagnostics
- Nail Diseases and Treatments
- Autoimmune Bullous Skin Diseases
- Vascular Tumors and Angiosarcomas
- Fungal Infections and Studies
- Genetic and rare skin diseases.
- interferon and immune responses
- Urticaria and Related Conditions
- Autoimmune and Inflammatory Disorders
- Cytokine Signaling Pathways and Interactions
- Oral Health Pathology and Treatment
- Infectious Diseases and Mycology
- Lymphoma Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cell Image Analysis Techniques
- CAR-T cell therapy research
- Inflammatory mediators and NSAID effects
University of Utah
2016-2025
John Wiley & Sons (United States)
2019
Syracuse University
2019
University of Memphis
2019
Texas A&M University
2019
Smith College
2019
Huntsman Cancer Institute
2001-2013
McKay Dee Hospital
2012
University of Utah Hospital
2012
Intermountain Healthcare
2012
Histopathologic examination is sometimes inadequate for accurate and reproducible diagnosis of certain melanocytic neoplasms. As a result, more sophisticated objective methods have been sought. The goal this study was to identify gene expression signature that reliably differentiated benign malignant lesions evaluate its potential clinical applicability. Herein, we describe the development validation using multiple independent cohorts representing broad spectrum histopathologic...
Familial melanoma patients are reported to present with thinner melanomas, be younger at the time of diagnosis, and have a greater likelihood developing multiple primary tumors. We sought determine whether melanomas that occur in familial setting demonstrate different prognostic survival statistics relative sporadic melanoma.This population-based study used Utah Cancer Registry Population Database objectively evaluate population. From 1973 1999, there were 7,785 cases invasive identified...
Abstract Purpose: UV radiation is the major environmental risk factor for melanoma and a potent inducer of oxidative stress, which implicated in pathogenesis several malignancies. We evaluated whether thiol antioxidant N-acetylcysteine (NAC) could protect melanocytes from UV-induced stress/damage vitro vivo. Experimental Design: In experiments used mouse melanocyte line melan-a. For vivo experiments, mice transgenic hepatocyte growth survivin, shown previously to develop following single...
BACKGROUND Our previous experience monitoring nevi in high-risk patients using serial digital epiluminescence microscopy (DELM) photography achieved low biopsy rates but was limited by melanomas presenting as new lesions or arising from that had not been photographed. OBJECTIVE To determine whether rates, efficiency of melanoma detection, and origin (de novo vs nevus derived) differed a similar patient population monitored total body (TB) photography. METHODS One thousand seventy-six...
To determine the optimal methods for pancreatic adenocarcinoma surveillance in high-risk patients with familial melanoma and cyclin-dependent kinase inhibitor 2A (CDKN2A) mutations.Case report pedigree analysis literature review, an emphasis on guideline development kindreds adenocarcinoma.A university-affiliated research clinic. Patients The proband was referred as a participant clinic protocol found to carry germline CDKN2A mutation have history of adenocarcinoma. A total 179 family...
The dysregulation of apoptosis occurs in many cutaneous disease states. Several inhibitors have been shown elevated neoplasms and some inflammatory conditions, but their relation to proliferative apoptotic states has not defined. We examined the expression inhibitor survivin a panel keratinocytic hyperproliferative skin lesions using both immunohistochemistry newly developed situ hybridization technique. Proliferation indices were also assessed by immunohistochemical staining for...
The role of selenium (Se) supplementation in cancer prevention is controversial; effects often depend on the nutritional status subject and chemical form which Se provided. We used a combination vitro vivo models to study two unique therapeutic windows for intervention process cutaneous melanomagenisis, examine utility different forms treatment melanoma. studied UV-induced oxidative stress melanocytes, apoptosis cell cycle progression melanoma cells. In vivo, we HGF transgenic mouse model...
Background: Distinguishing merkel cell carcinoma (MCC), small lung (SCLC) metastatic to the skin, and atypical basal (BCC) can be problematic in some cases. Significant differences biology of these tumors necessitate that they need distinguished from one another. Methods: We evaluated immunophenotypic characteristics 22 MCCs, nine SCLCs, 19 BCCs using antibodies cytokeratin 20 (CK20), thyroid transcription factor‐1 (TTF‐1), CD117, DNA topoisomerase II‐α (topo II). Results: Nineteen MCCs...
Atypical nevi are a common risk factor for melanoma.The objective was to determine the utility of monitoring dermoscopic photographs atypical in high-risk population.Over 4.5-year period, digital were taken clinically at initial and follow-up visits, such that side-by-side comparisons could be made.A total 5,945 lesions monitored 297 patients over 3 52 months (median, 22 months), 324 biopsied. Photographic (dermoscopic) changes noted 96 (1.6%) lesions, which included 64 dysplastic (67%), 25...
Several reports have documented the coexistence of basal cell carcinoma (BCC) with other lesions, including melanoma. This study was performed to determine whether nests BCC contain benign melanocytes and Langerhan's cells. Ten cases were investigated cells populate tumor nests. The BCCs stained antibodies cytokeratin AE1/AE3, S-100, HMB-45, Melan-A, CD1a proteins. We report that all 10 populated by dendritic distributed at periphery (5/10 cases) or evenly throughout cases). Clusters not...
Objectives: To assess interobserver and intraobserver concordance for identifying positive negative margins in staged excisions of lentigo maligna melanoma to determine if control biopsy specimens are useful improve concordance.Design: Retrospective, randomized comparison study archived pathologic specimens.The was conducted 3 phases, slides were evaluated blindly independently by 5 pathologists: phase 1, all diagnosed as or negative.In 2, every third slide again 3, organized into cases,...
Our purpose was to evaluate the interobserver concordance for diagnoses of mycosis fungoides (MF), atypical dermatoses (AD), and benign (BD) impact T-cell immunophenotyping on MF, AD, BD. Specimens MF (n = 57), AD 27), BD normal skin 54) were reviewed by 2 hematopathologists 1 dermatopathologist establish diagnostic routine morphologic examination. Immunophenotyping performed expression CD2, CD3, CD4, CD5, CD7, CD8, CD20, CD30, MIB-1. The fair moderate compared with original diagnosis....