A5005799812- Cutaneous Melanoma Detection and Management
- Cell Image Analysis Techniques
- Advanced Fluorescence Microscopy Techniques
- Cutaneous lymphoproliferative disorders research
- Advanced Biosensing Techniques and Applications
- Skin Protection and Aging
- Optical Coherence Tomography Applications
- Rheumatoid Arthritis Research and Therapies
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- Dermatologic Treatments and Research
- Viral-associated cancers and disorders
- melanin and skin pigmentation
- Orthopedic Infections and Treatments
- Nonmelanoma Skin Cancer Studies
- Sepsis Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Genetic and rare skin diseases.
- Hedgehog Signaling Pathway Studies
- Tumors and Oncological Cases
- Orthopedic Surgery and Rehabilitation
- Immunotherapy and Immune Responses
- Dermatological and Skeletal Disorders
- Vascular Tumors and Angiosarcomas
- Cancer and Skin Lesions
United Health Services
2019-2025
Duke University
2023-2024
Piedmont International University
2024
Duke Medical Center
2023
Target (United States)
2021
Laguna Research
2021
University of California, Irvine
2012-2020
MD Anderson Cancer Center Madrid
2019
Saarland University
2014
Beckman Laser Institute and Medical Clinic
2014
Basal cell carcinomas (BCCs) are diagnosed by clinical evaluation, which can include dermoscopic biopsy, and histopathologic examination. Recent translation of multiphoton microscopy (MPM) to practice raises the possibility noninvasive, label-free in vivo imaging BCCs that could reduce time from consultation treatment.To demonstrate capability MPM image BCC lesions human skin, evaluate if criteria be identified images.Imaging patients with was performed at University California-Irvine Health...
Abstract Monitoring of atypical nevi is an important step in early detection melanoma, a clinical imperative preventing the disease progression. Current standard diagnosis based on biopsy and histopathologic examination, method that invasive highly dependent upon physician experience. In this work, we used multiphoton microscope to image vivo noninvasively melanocytic at three different stages: common without dysplastic changes, with structural architectural atypia, melanoma. We analyzed...
In vivo, label-free evaluation of mitochondrial function in human skin epithelia noninvasively differentiates healthy from cancerous tissues.
Abstract We introduce a compact, fast large area multiphoton exoscope (FLAME) system with enhanced molecular contrast for macroscopic imaging of human skin microscopic resolution. A versatile platform, FLAME combines optical and mechanical scanning mechanisms deep learning image restoration to produce depth-resolved images that encompass sub-mm 2 cm scale areas tissue within minutes provide means comprehensive analysis live or resected thick tissue. The which expands on design recently...
The rate of removal radioactive sodium from No S a tissue has been shown by Kety (1949) to be quantitative measure the local circulation.This technique used extensively study __ _ -..... circulation in skin, subcutaneous tissue, and muscle _-- (McGirr, 1952), it applied 5 normal human knee joint (Jacox, Johnson, Koontz, 1952; Harris Millard, 1956).In _.-__ our previous study, simple exponential curves were consistently found.When counting was z -....... plotted semi-logarithmically against...
Abstract Melasma is a skin disorder characterized by hyperpigmented patches due to increased melanin production and deposition. In this pilot study, we evaluate the potential of multiphoton microscopy (MPM) characterize non‐invasively content, location, distribution in melasma assess elastosis severity. We employed clinical MPM tomograph image vivo morphological features lesions adjacent normal 12 patients. imaged dermal melanophages most occasionally epidermal melasma. The volume fraction...
Our purpose was to evaluate the interobserver concordance for diagnoses of mycosis fungoides (MF), atypical dermatoses (AD), and benign (BD) impact T-cell immunophenotyping on MF, AD, BD. Specimens MF (n = 57), AD 27), BD normal skin 54) were reviewed by 2 hematopathologists 1 dermatopathologist establish diagnostic routine morphologic examination. Immunophenotyping performed expression CD2, CD3, CD4, CD5, CD7, CD8, CD20, CD30, MIB-1. The fair moderate compared with original diagnosis....
Mycosis fungoides (MF) classically presents with a CD4+/CD8- immunophenotype at the time of diagnosis. MF may extremely rarely present CD8+/CD4- and, even more rarely, shift between CD4+ and CD8+ phenotypes. To date, very few phenotypic shifts in have been reported, just two them were to direction. Our case report describes another instance MF, but associated transformation anaplastic lymphoma kinase (ALK)-negative large cell (ALCL) - first documented its kind. We hope spread awareness about...
Our purpose was to evaluate the interobserver concordance for diagnoses of mycosis fungoides (MF), atypical dermatoses (AD), and benign (BD) impact T-cell immunophenotyping on MF, AD, BD. Specimens MF (n = 57), AD 27), BD normal skin 54) were reviewed by 2 hematopathologists 1 dermatopathologist establish diagnostic routine morphologic examination. Immunophenotyping performed expression CD2, CD3, CD4, CD5, CD7, CD8, CD20, CD30, MIB-1. The fair moderate compared with original diagnosis....
Background and Purpose. In 2003, The University of Utah initiated the Cultural Competency Mutual Respect (CCMR) educational program for Interdisciplinary Health Sciences Students (IHSS), professionals in medicine (MED), pharmacy (PHARM), nursing (NSG), physical therapy (PT), others. This 3-year study assessed pre/post learning outcomes CCMR through Campinha-Bacote's Inventory Assessing Process Competence-Revised (IAPCC-R©).1-4 Subjects. A total 2,124 IHSS students, participating modules,...
Background: Post‐transplant lymphoproliferative disorder (PTLD) is a condition affecting immunosuppressed transplant patients and has variety of clinical presentations. It rarely found in the skin, cases PTLD skin are usually linked with lymph node or other organ involvement. Methods: We report case plasmacytoid that limited to skin. A 63‐year‐old man history cardiac presented exophytic tumors involving lower extremity. The diagnosis classification various forms discussed. Results:...
Multiphoton microscopy (MPM) is a promising non-invasive imaging tool for discriminating benign nevi from melanoma. In this study, we establish MPM morphologic catalogue of common nevi, information that will be critical in devising strategies to distinguish them are evolving melanoma may present with more subtle signs malignancy. Thirty melanocytic were imaged vivo using MPM. Quantitative parameters can between different types developed and confirmed by examining the histology eleven nevi....