A5043635194- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Gut microbiota and health
- Immune Response and Inflammation
- Sarcoidosis and Beryllium Toxicity Research
- Neonatal Respiratory Health Research
- Immunotherapy and Immune Responses
- Renal Transplantation Outcomes and Treatments
- IL-33, ST2, and ILC Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Gene expression and cancer classification
- SARS-CoV-2 and COVID-19 Research
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Dermatology and Skin Diseases
- Organ Transplantation Techniques and Outcomes
- Metabolomics and Mass Spectrometry Studies
- Genomics and Phylogenetic Studies
- Clostridium difficile and Clostridium perfringens research
University of Illinois Chicago
2016-2025
University of New Mexico
2023-2025
Radiology Associates of Albuquerque
2023
University of Chicago
2023
United States Fish and Wildlife Service
2018-2022
Animal and Plant Health Inspection Service
2022
Rush University Medical Center
2021
Illinois College
2021
University of Illinois Urbana-Champaign
2014-2021
Office of Minority Health
2021
Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed examine relationships of tryptophan with incident type 2 diabetes (T2D), genetics, diet gut microbiota.
Abstract T cell activation requires at least two distinct signals, including signaling via the Ag-specific TCR and a costimulatory pathway. The best characterized pathway involves CD28 molecule, which is expressed constitutively on cells binds family of B7 counter-receptors APCs. Inhibition this prevents can lead to long-term unresponsiveness or anergy. In contrast, CTLA4, homologous CD28, has been shown be negative regulator activation. CTLA4 molecule not resting cells, but induced after...
To the Editor: Sarcoidosis is a chronic disease characterised by granulomatous depositions that can occur in virtually any organ system [1]. Currently, there no US Food and Drug Administration (FDA)-approved therapy for sarcoidosis; however, corticosteroids have proven efficacious are commonly used treatment [2]. In patients with or pulmonary who do not respond to corticosteroids, whom steroid use contraindicated, agents such as methotrexate, azathioprine tumour necrosis factor (TNF)-α...
Hyperactive and damaging inflammation is a hallmark of severe rather than mild Coronavirus disease 2019 (COVID-19). To uncover key inflammatory differentiators between COVID-19, we applied an unbiased single-cell transcriptomic analysis. We integrated two RNA-seq datasets with COVID-19 patient samples, one that sequenced bronchoalveolar lavage (BAL) cells peripheral blood mononuclear (PBMCs). The combined cell population was then analyzed focus on genes associated severity. immunomodulatory...
Toll-like receptors (TLRs) recognize highly conserved microbial molecular patterns, such as found in endotoxin. This study tested whether TLR4 and TLR2 stimulation vivo would modulate subsequent adaptive (allergic) immune responses. We analyzed the effects of pulmonary administration a agonist, lipid A (LpA), two agonists, peptidoglycan (Ppg) PamCys, murine model allergic inflammation. The TLR agonists were administered during allergen sensitization or challenge. Both decreased...
Report17 April 2007Open Access Hubs in biological interaction networks exhibit low changes expression experimental asthma Xin Lu Corresponding Author Department of Family and Preventive Medicine, University California at San Diego, CA, USA Search for more papers by this author Vipul V Jain Patricia W Finn David L Perkins Surgery, Information 1,2, Jain2, Finn2 Perkins2,3 1Department 2Department 3Department *Corresponding author. 9500 Gilman Dr., MC 0645, La Jolla, CA 92093, USA. Tel.: +1 858...
Activation of naive T cells requires at least two signals. In addition to the well characterized interaction cell antigen receptor with antigen/MHC expressed on an antigen-presenting cell, activation also costimulation by a second set The best costimulatory is CD28, which binds family B7 ligands cells. asthma, although activated play role in initiation and maintenance airway inflammation, importance bronchial hyperresponsiveness had not been characterized. Therefore, we tested hypothesis...
Obesity is a growing epidemic in most developed countries including the United States resulting an increased number of obese patients with end-stage renal disease. A previous study has shown that disease have survival benefit transplantation compared dialysis. However, due to serious comorbidities, many centers place restrictions on selection for transplantation. Further, having risk diabetes, it unclear whether obesity can be independent risk, diabetes increasing adverse transplant...
Abstract Serotonin transporter (SERT) plays a critical role in regulating extracellular availability of serotonin (5-HT) the gut and brain. Mice with deletion SERT develop metabolic syndrome as they age. Changes microbiota are being increasingly implicated Metabolic Syndrome Diabetes. To investigate relationship between microbiome SERT, this study assessed fecal cecal profile 11 to 12 week-old +/+ −/− mice. Microbial DNA was isolated, processed for metagenomics shotgun sequencing, taxonomic...
T cell activation and cytokine secretion are important mediators of inflammation in allergic asthma. The costimulatory pathway CD28/CD80/CD86 has been shown to play an role cellactivation asthma, but less is known about the effect other molecules allergy. molecule OX40 ligand (OX40L), a member tumor necrosis factorsuperfamily, be priming production. We investigated OX40L murine model using OX40L–/– mice. In this model, following OVA sensitization challenge, mice develop features including...
Abstract Recent studies have established that the human urine contains a complex microbiome, including virome about which little is known. Following immunosuppression in kidney transplant patients, BK polyomavirus (BKV) has been shown to induce nephropathy (BKVN), decreasing graft survival. In this study we investigated profile of BKV+ and BKV− recipients. Virus-like particles were stained confirm presence VLP samples. Metagenomic DNA was purified, analyzed using metagenomic shotgun...
Microbial longitudinal studies are powerful experimental designs utilized to classify diseases, determine prognosis, and analyze microbial systems dynamics. In studies, only identifying differential features between two phenotypes does not provide sufficient information whether a change in the relative abundance is short-term or continuous. Furthermore, sample collection suffers from all forms of variability such as different number subjects per phenotypic group, samples subject, collected...
Olfactory receptor-78 (Olfr-78) is a recently identified G protein-coupled receptor activated by short-chain fatty acids acetate and propionate. A suggested role for this exists in the prostate where it may influence chronic inflammatory response leading to intraepithelial neoplasia. Olfr-78 has also been shown be expressed mouse colon. Short-chain their receptors are well known modulate inflammation gut. Considering possibility, we first explored if colitis regulated expression gut,...
Background. Both animal models and clinical outcomes studies of transplantation suggest that antigen-independent mechanisms can alter graft survival function. It has been suggested processes interact with alloantigen-specific responses to augment the rejection reaction. A major link between antigen-specific adaptive immunity pro-inflammatory stimuli is innate immunity. During transplantation, may be stimulated by multiple factors, including ischemia, reperfusion, sterile injury, systemic...
Background. Interleukin (IL)-6 is a pleiotropic cytokine that functions in both the innate and adaptive immune responses. However, role of IL-6 allograft rejection remains poorly understood. Methods. In this study, we demonstrate critical for graft-produced murine model cardiac transplantation. Results. The results show IL-6-deficient grafts transplanted into allogeneic wild-type recipients have significantly prolonged survival, approximately three times survival time controls. contrast,...
We have used an approach of linking previously characterized T cell epitopes into immunologically complex synthetic peptides in order to investigate the mechanism immunodominance. Our results show that first, cI12-26 is highly dominant following immunization with lambda repressor (cI) protein, but a minor epitope context cI:NP peptide. In contrast, response peptide new junctional epitope, which composed sequences derived from both cI and influenza nucleoprotein (NP) segments composite...
The majority of human T-cell leukemia virus isolates (HTLV-I) are associated with clinically aggressive adult leukemia/lymphomas. By contrast, HTLV-II has been isolated from a patient relatively benign hairy leukemia. To characterize differences in the viral genomes that might contribute to these different pathologies, we determined nucleotide sequence long terminal repeat (LTR) provirus. Comparison type I HTLV LTR reveals that, whereas overall structural features similar, two sequences...
Abstract Background Maternal atopic background and stimulation of the adaptive immune system with allergen interact in development allergic disease. Stimulation innate through microbial exposure, such as activation Toll-like-receptor 2 (TLR2), may reduce allergy childhood. However, little is known about immunological effects on early responses association maternal atopy. Methods We analyzed cord blood mononuclear cells (CBMC) from 50 healthy neonates (31 non-atopic 19 mothers). Cells were...