Multiscale entropy (MSE) analysis is a novel entropy-based method for quantifying the complexity of dynamic neural signals and physiological systems across multiple temporal scales.This approach may assist in elucidating pathophysiologic mechanisms amnestic mild cognitive impairment (aMCI) Alzheimer's disease (AD).Using resting-state fNIRS imaging, we recorded spontaneous brain activity from 31 healthy controls (HC), 27 patients with aMCI, 24 AD.The quantitative MSE revealed that reduced...

Communication within the brain is highly dynamic. Alzheimer's disease (AD) exhibits dynamic progression corresponding to a decline in memory and cognition. However, little known of whether dynamics are disrupted AD its prodromal stage, mild cognitive impairment (MCI). For our study, we acquired high sampling rate functional near-infrared spectroscopy imaging data at rest from entire cortex 23 patients with dementia, 25 amnestic (aMCI), 30 age-matched healthy controls (HCs). Sliding-window...

Introduction: With around 25 different salivary gland tumor entities described by the World Health Organization, correct preoperative identification of masses as benign or malignant remains a challenge. If needle biopsy is inconclusive, frozen section analysis possible alternative for accurate histological identification. The purpose our study was to evaluate diagnostic effectiveness performed primary submandibular masses. Methods: In addition acquiring epidemiological data from patients who...

Hypoglossal nerve stimulation (HNS) is a novel therapy in the treatment of obstructive sleep apnea. Previous studies have focused on effectiveness HNS, but there are no specifically investigating long-term changes intensities HNS. Increasing intensity requirements been reported past other peripheral therapies. The aim this study was to investigate development over observation period 4 years.All patients who were implanted with an HNS system since December 2013 and maintained bipolar...

oneAPI is based on Data Parallel C++ (DPC++) and incorporates SYCL from the Khronos Group to support a cross-architecture programming environment. It delivers freedom choose suitable hardware for specific applications. In this paper, we developed real-time medical ultrasound imaging application using an open-source project SUPRA [1]. The takes raw data equipment as input processes it obtain B-mode images. processing pipeline contains four modules: Beamforming, Envelope Detection,...

Introduction: Hereditary angioedema (HAE) is a disease that leads to recurrent swelling of the skin and mucous membranes, including upper airway tract. Apart from being deadly, these attacks can be debilitating, which poor quality life in patients. Clinicians are occasionally confronted with patients who have despite treatment C1 esterase inhibitor concentrate or β 2 -receptor antagonists. The goal this study was investigate repeated occur 48 hours 7 days (“cluster attacks”) after treatment,...

Therapies of head and neck squamous cell carcinoma (HNSCC), particularly irradiation chemotherapy (C/RT), can affect salivary glands to some extent. Recent studies suggest that point shear wave elastography (pSWE) is well suited for the diagnosis rating homogenous damage parenchymatous organs. The purpose this study was assess value sonographic modality as a tool evaluation both gland affection after HNSCC therapy effect replacement based on liposomes. A total 69 patients were included in...

Sarcoidosis is a systemic inflammatory disease characterized by non-caseating granulomas. In addition to the lungs as classical site of affection, extrapulmonary manifestations are common, for example in cervical lymph nodes or salivary glands. The aim this investigation analysis long-term course glandular symptoms and sonographic evaluation gland changes. All patients with diagnosis sarcoidosis over period 20 years departments otorhinolaryngology, rheumatology, pneumology were identified....

Introduction Type-2 biologics allow for successful treatment of patients with severe chronic rhinosinusitis nasal polyps (CRSwNP). Eosinophils have been established as a reliable biomarker type-2 disease and enable the differentiation inflammatory patterns in CRSwNP. Aim this study was to evaluate, whether peripheral blood eosinophilia before initiation therapy allows assesment response

Introduction Hypoglossal nerve stimulation is an established therapy for patients suffering from obstructive sleep apnea. Recently, it has been shown that the presence of a complete lateral wall collapse at oropharyngeal level in preoperative drug induced endoscopy might by associated with less favorable response to hypoglossal stimulation. Since bilateral concentric soft palate, we investigated, if also could benefit this therapy.

Introduction Hypoglossal nerve stimulation is an established treatment for obstructive sleep apnea with CPAP incompliance. Women show a better response to therapy, but specific reasons this are still unclear. We investigated whether there gender-specific differences in the change of electrode configuration during follow-up.

Einleitung Die Hypoglossusnervstimulation ist eine etablierte Behandlungsmethode der obstruktiven Schlafapnoe bei CPAP-Incompliance. Frauen zeigen ein besseres Therapieansprechen, spezifische Gründe dafür sind bisher unklar. Es wurde untersucht, ob es in Nachsorge geschlechtsspezifische Unterschiede Änderung Elektrodenkonfiguration gibt. Material und Methode: erfolgte die retrospektive Analyse von 237 PatientInnen (32 Frauen, 205 Männer) über einen Nachsorgezeitraum bis zu 6 Jahren nach...

Einführung Die Neurostimulation des Nervus hypoglossus ist eine etablierte Therapie bei Patienten mit obstruktiver Schlafapnoe (OSA). Kürzlich wurde gezeigt, dass ein kompletter oropharyngealer lateraler Kollaps in der medikamentös induzierten Schlafvideoendoskopie möglicher negativer Prädiktor bzgl. Therapieansprechens kann.Nachdem die bilaterale Stimulation positive Effekte auch einem komplett konzentrischen auf Velumebene gezeigt hatte, nun Frage untersucht, ob komplettem lateralen...

Die initiale Vorstellung des Patienten erfolgte im Juli 2023 mit progredienter Visusminderung, Doppelbildern, Cephalgie und frontaler Sensibilitätsstörung rechts. Vier Wochen zuvor war alio loco eine beidseitige FESS erfolgt, die Histologie sowie Mikrobiologie ergaben hier lediglich den Nachweis von Strp. constallatus. Aufgrund der Kombination nun vollständiger Erblindung Ophthalmoplegie wurde Diagnose eines Apex orbitae Syndroms unklarer Genese gestellt. angeschlossene Bildgebung mittels...

Introduction Structured tumor aftercare is considered the most important component in treatment of patients after completion therapy. As regular examinations are often associated with a high financial and time expenditure for patients, question arises possible complement sense digital which could be used to record patient-reported outcome measures [1]. These have been shown lead an improved quality life [2]. However, it still unclear what extent majority older will accept digitally supported...

Introduction Hypoglossal nerve stimulation (HNS) effectively treats obstructive sleep apnea (OSA), but nonresponders (NR) occur at 28-34% (1). NR have not been well characterized so far. The aim of this study was to identify significant differences between therapy responders (R) find potential predictors for a good outcome.

Einleitung Die Hypoglossusnervstimulation (HNS) ist eine wirksame Therapie bei obstruktiver Schlafapnoe (OSA), aber die Therapie-Nonresponder-Rate (NR) beträgt 28-34%. Bisher wurden NR nicht umfassend charakterisiert. Ziel war es, Entwicklung der zu untersuchen und Unterschiede Therapie-Respondern (R) finden.

Case The patient first presented with progressive vision loss as well double vision, head ache and frontal of sensibility in July 2023. Four weeks ahead he underwent sinus surgery, the histological microbiological examinations brought up presence streptococcus constallatus. Due to complete loss, ophthalmolplegia was diagnosed orbital apex syndrome unknown cause. CT MRI scans showed a compression right optic nerve by an expanding leasion around posterior funnel. More sphenoid were performed...

Zusammenfassung Hintergrund „Patient-reported outcome measures“ führen bei Tumorpatient*innen sowohl zu einer verbesserten Lebensqualität als auch möglicherweise früheren Erkennung von Tumorrezidiven. Fragestellung Erfragt wurde das Interesse der Patient*innen an Ergänzung Tumornachsorge durch Apps zur Erfassung (patient-reported [PRO]). Material und Methode Dazu erfolgte die Auswertung eines selbstständig erstellten Fragebogens des Interesses digitalisierten Form ( n = 110) Ergebnisse In...

Zusammenfassung Die Wiedererlangung einer Stimmfunktion nach Laryngektomie ist ein zentrales Element für die postoperative Lebensqualität. Dazu haben sich Stimmprothesen als probates Mittel etabliert. Häufige Prothesenwechsel stellen einige Patienten jedoch eine teils große Belastung dar, sodass besseres Verständnis der Ätiologie Stimmprothesen- und Stimmprothesenlagerinsuffizienz benötigt wird. Material Methoden Es erfolgte retrospektive Auswertung klinischer Daten von 58 Laryngektomie. Des...

Xerostomia and keratoconjunctivitis sicca are the main symptoms of Sjögren's syndrome. Often patients also suffer from laryngeal complaints, but there is a lack specific treatment options. The aim this study was to evaluate effect liposomal inhalation therapy. Patients with syndrome were included received two-month period evaluated by standardized questionnaires (patient-reported indices) measurement unstimulated whole salivary flow glandular stiffness. Forty-five in study. A comparison...