A5084751484- Infrared Thermography in Medicine
- Acute Myocardial Infarction Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Extracellular vesicles in disease
- Cardiovascular Disease and Adiposity
- Cancer Immunotherapy and Biomarkers
- Cardiac Imaging and Diagnostics
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Thermal Regulation in Medicine
- COVID-19 diagnosis using AI
- Blood Pressure and Hypertension Studies
- Thermoregulation and physiological responses
- thermodynamics and calorimetric analyses
- Chemotherapy-induced cardiotoxicity and mitigation
- Climate Change and Health Impacts
- Coronary Interventions and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Virus-based gene therapy research
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Dialysis and Renal Disease Management
- Cardiac electrophysiology and arrhythmias
Tel Aviv University
2017-2025
Tel Aviv Sourasky Medical Center
2017-2025
Sheba Medical Center
2019-2024
Afeka College of Engineering
2023
Background: The role of epicardial fat (eFat)-derived extracellular vesicles (EVs) in the pathogenesis atrial fibrillation (AF) has never been studied. We tested hypothesis that eFat-EVs transmit proinflammatory, profibrotic, and proarrhythmic molecules induce myopathy fibrillation. Methods: collected eFat specimens from patients with (n=32) without AF (n=30) during elective heart surgery. samples were grown as organ cultures, culture medium was every 2 days. then isolated purified medium,...
Abstract Background Immune checkpoint inhibitors (ICIs) have revolutionized the prognosis of cancer. Diabetes mellitus (DM) has been shown to a negative effect on patients treated with ICIs. Sodium-glucose cotransporter 2 (SGLT2i) are effective antidiabetic therapies associated reduced all-cause mortality and cardiovascular (CV) outcomes. Objective To evaluate prognostic value SGLT2i cardiotoxicity among Methods We performed retrospective analysis diagnosed cancer type DM (DM2) ICIs at our...
Abstract Introduction The use of intestinal ultrasound (IUS) for the diagnosis and follow-up inflammatory bowel disease is steadily growing. Although access to educational platforms IUS feasible, novice operators lack experience in performing interpreting IUS. An artificial intelligence (AI)–based operator supporting system that automatically detects wall inflammation may simplify by less experienced operators. Our aim was develop validate an module can distinguish thickening (a surrogate...
Chronic obstructive pulmonary disease (COPD) is an inflammatory characterized by a progressive and irreversible deterioration of lung function. Exacerbations COPD have prolonged negative effects on function major impact health status outcomes. NLRP3 inflammasome cardinal component the response, with marked evidence in stable exacerbations COPD. The aim our study was to evaluate activity during exacerbation using vitro model.A549 cells were stimulated different concentrations (10%, 4%, 2%)...
Abstract Rapid and sensitive screening tools for SARS-CoV-2 infection are essential to limit the spread of COVID-19 properly allocate national resources. Here, we developed a new point-of-care, non-contact thermal imaging tool detect COVID-19, based on advanced image processing algorithms. We captured images backs individuals with without using portable camera that connects directly smartphones. Our novel algorithms automatically extracted multiple texture shape features achieved an area...
Abstract COVID‐19‐related pneumonia is typically diagnosed using chest x‐ray or computed tomography images. However, these techniques can only be used in hospitals. In contrast, thermal cameras are portable, inexpensive devices that connected to smartphones. Thus, they detect and monitor medical conditions outside Herein, a smartphone‐based application images of human back was developed for COVID‐19 detection. Image analysis deep learning algorithm revealed sensitivity specificity 88.7%...
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment outcomes. However, the response varies across different populations, and their use may lead to life-threatening cardiovascular (CV) events. While pre-treatment reduced left ventricular ejection fraction (LVEF) is considered a marker for high-risk cardiotoxicity contraindication anthracycline HER2-targeted therapies, there limited evidence on safety efficacy of ICIs therapy in patients presenting with LVEF. The study...
Abstract Introduction The C‐reactive protein (CRP)‐troponin‐test (CTT) comprises simultaneous serial measurements of CRP and cardiac troponin might reflect the systemic inflammatory response in patients with acute coronary syndrome. We sought to test its ability stratify short‐ long‐term mortality risk non‐ST elevation myocardial infarction (NSTEMI). Methods examined 1,675 diagnosed NSTEMI on discharge who had at least two successive combined within 48 h admission. A tree classifier model...
Abstract Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of progressive pathologies, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. A biopsy is currently required stratify high-risk patients, predicting the degree inflammation using non-invasive tests remains challenging. Here, we sought develop novel, cost-effective screening tool for NAFLD based on thermal imaging. We used commercially available camera developed new image...
Malignant tumors have high metabolic and perfusion rates, which result in a unique temperature distribution as compared to healthy tissues. Here, we sought characterize the thermal response of cervix following brachytherapy women with advanced cervical carcinoma. Six patients underwent imaging camera before treatment session after 7-day follow-up period. A designated algorithm was used calculate store texture parameters examined tissues across all time points. We supervised machine learning...
Thermal infrared imaging has been suggested as a non-invasive alternative to monitor physiological processes and disease. However, the use of this technique image internal organs, such heart, not yet investigated. We sought determine ability our novel thermal image-processing algorithm detect structural functional changes in mouse model hypertension cardiac remodeling. Twelve mice were randomly assigned receive either pro-inflammatory, hypertensive hormone angiotensin-II (2 mg/kg/day, n = 6)...
Elevated concentrations of C-reactive protein (CRP) early during an acute coronary syndrome (ACS) may reflect the magnitude inflammatory response to myocardial damage and are associated with worse outcome. However, routine measurement both CRP cardiac troponin simultaneously in setting ST-segment infarction (STEMI) is not used broadly. Here, we sought identify characterize individuals who prone elevated following STEMI by using a combined test (CTT) determine their short- long-term We...
Albuminuria is an established marker for endothelial dysfunction and cardiovascular risk in diabetes prediabetes. Exercise induced albuminuria (EiA) appears earlier may be a more sensitive biomarker renal damage. We sought to examine the association between EiA, parameters of metabolic syndrome, A1C levels, exercise ECG test results sex related differences large cohort healthy, pre-diabetic diabetic subjects. A total 3029 participants from Tel-Aviv Medical Center Inflammation Survey (mean...
Inflammation and fibrosis limit the reparative properties of human mesenchymal stromal cells (hMSCs). We hypothesized that disrupting toll-like receptor 4 (TLR4) gene would switch hMSCs toward a phenotype improve outcome cell therapy for infarct repair. developed optimized an improved electroporation protocol CRISPR-Cas9 editing. This achieved 68% success rate when applied to isolated from heart epicardial fat patients with ischemic disease. While editing lowered TLR4 expression in hMSCs, it...
<h3>Introduction/Background</h3> Cervical cancer poses a significant global health threat, necessitating comprehensive treatment approaches. Brachytherapy stands out as crucial component in combating this disease. The success of cervical relies heavily on the effective monitoring tissue response, ensuring both efficacy and well-being patients. <h3>Methodology</h3> This study focused nine patients who underwent thermal imaging assessments before after brachytherapy session involving 5.5Gy...
Metabolic syndrome (MetS) and high-sensitivity cardiac troponin T (hs-TnT) are associated with higher risk for cardiovascular diseases (CVD). Our aim was to assess the relation between hs-TnT elevation MetS in a general population sample.Individuals participating an annual health survey program 2010 2016 were included study. Blood samples including levels collected. The study divided into three groups based on - undetectable (<5 ng/L), intermediate (5-14 ng/L) elevated (>14 ng/L).A total of...
Abstract Background The exercise ECG stress test ( EST ) is still the first step of work‐up in intermediate risk patients many clinical scenarios. High‐sensitive cardiac troponin T (hs‐ cTnT elevation related to future cardiovascular events general population and with ischaemic heart disease. relation between these 2 tests not well described. Materials methods A total 2780 participants from Tel‐Aviv Medical Center Inflammation Survey cohort (mean age 49 years, 79% men) were analysed....
The global prevalence of metabolic syndrome and its association with increased morbidity mortality has been rigorously studied. However, the true "metabolic health", i.e. individuals without any abnormalities is not clear. Here, we sought to determine "metabolically healthy" characterize "transition phase" from health development dysfunction over a follow-up period 5 years.We included 20,507 Tel Aviv Sourasky Medical Center Inflammation Survey (TAMCIS) which comprises apparently healthy...
Imbalanced autonomic nervous system (ANS) activity is associated with poor cardiovascular outcome. However, clinically validated biomarkers to assess parasympathetic function are not yet available. We sought evaluate dysfunction by measuring serum cholinesterase and determine its relationship high sensitive cardiac troponin T (hs-cTnT) as well traditional non-invasive parameters of ANS during exercise in apparently healthy individuals.We enrolled 1526 individuals (mean age 49 ± 11 yr., 75%...