Aqueous extracts from seeds of Areca catechu L. (Arecaceae) (AC) and nutgalls Quercus infectoria Oliv. (Fagaceae) (QI) were investigated for their hepatoprotective potential by studying antioxidant capacity using four different methods, determining in vitro anti−inflammatory activity against 5-lipoxygenase, evaluating liver injury induced carbon tetrachloride (CCl4) rats. AC QI exhibited potent anti-inflammatory activities. Treatment rats with reversed oxidative damage hepatic tissues CCl4....

Three polyphenolic principles, 1,2,3,4,6-penta-O-galloyl-β‐D-glucopyranose (PGG), methyl gallate (MG), and gallic acid (GA), were isolated from the ethanolic extract of seed kernels Thai mango (MSKE) (Mangifera indica L. cv. "Fahlun") quantified using a TLC scanning densitometric method. The MSKE its isolates investigated by studying their antioxidant capacities four different methods, determining in vitro anti-inflammatory activities, evaluating hepatoprotective potential against liver...

The ethanolic extract from seed kernels of Thai mango (MSKE) (Mangifera indica L. cv. ‘Fahlun’) (Anacardiaceae) and its major phenolic principle (pentagalloyl glucopyranose) exhibited dose-dependent inhibitory effects on enzymatic activities phospholipase A2 (PLA2), hyaluronidase L-amino acid oxidase (LAAO) Calloselasma rhodostoma (CR) Naja naja kaouthia (NK)venoms by in vitro tests. anti-hemorrhagic anti-dermonecrotic MSKE against both venoms were clearly supported vivo Molecular docking...

The alcoholic extract from seed kernels of Thai mango (Mangifera indica L. cv. ‘Fahlun’) (Anacardiaceae) and its major phenolic principle (pentagalloylglucopyranose) exhibited potent, dose-dependent inhibitory effects on tyrosinase with respect to L-DOPA. Molecular docking studies revealed that the binding orientations principles were in pocket their located hydrophobic surrounding binuclear copper active site. results indicated a possible mechanism for anti-tyrosinase activity which may...

Snakebite envenomations cause severe local tissue necrosis and the venom metalloproteinases are thought to be key toxins involved. In this study, ethanolic extract from seed kernels of Thai mango (Mangifera indica L. cv. ‘Fahlun’) (Anacardiaceae) its major phenolic principle (pentagalloylglucopyranose) exhibited potent dose−dependent inhibitory effects on caseinolytic fibrinogenolytic activities Malayan pit viper cobra venoms in vitro tests. molecular docking studies revealed that binding...

Oncolytic adenoviruses rank among the most promising innovative agents in cancer therapy. We examined potential of boosting efficacy oncolytic adenovirus dl520 by associating it with magnetic nanoparticles and magnetic-field-guided infection multidrug-resistant (MDR) cells vitro upon intratumoral injection vivo. The virus was complexed self-assembly core−shell having a magnetite core about 10 nm stabilized shell containing 68 mass % lithium 3-[2-(perfluoroalkyl)ethylthio]propionate) 32 25...

Plant extracts are a valuable source of novel antibacterial compounds to combat pathogenic isolates methicillin-resistant Staphylococcus aureus (MRSA), global nosocomial infection. In this study, the alcoholic extract from Thai mango (Mangifera indica L. cv. ‘Fahlun’) seed kernel (MSKE) and its phenolic principles (gallic acid, methyl gallate pentagalloylglucopyranose) demonstrated potent in vitro activity against 19 clinical MRSA studies disc diffusion, broth microdilution time-kill assays....

The aims of this study were to investigate the potential benefits antioxidant, anti-inflammatory, anti-hepatotoxic, and anti-tyrosinase activities a methanolic extract fresh tea leaves (FTE) (Camellia sinensis L.). antioxidant capacity was investigated using three different methods at temperatures. anti-inflammatory activity studied in vitro by inhibition 5-lipoxygenase assay. anti-hepatotoxic effect CCl₄-induced liver injury rats. FTE its principal phenolic compounds...

Abstract The essential oil of Zingiber cassumunar (Plai oil) exhibits antimicrobial activity against a wide range Gram‐positive and Gram‐negative bacteria, dermatophytes yeasts. Dermatophytes were found to be the most susceptible microorganisms followed by yeasts, whereas bacteria least susceptible. mean diameter inhibition zone determined disc diffusion screening method increased with increasing Plai concentration between 6.25 50 vol %. minimum bactericidal (MBC) broth macrodilution ranged...

The methanolic extract of fresh tea leaves Camellia sinensis L. (Theaceae) (CS) was assayed for its potential to inhibit enzymes with hydrolytic activity in Naja naja kaouthia Lesson (Elapidae) and Calloselasma rhodostoma Kuhl (Viperidae) venoms. These snake venom are responsible the early effects envenomation, such as local tissue damage inflammation. CS inhibited phospholipase A(2), proteases, hyaluronidase L-amino acid oxidase both venoms by vitro neutralization hemorrhagic dermonecrotic...

Mango seed kernel extract (MSKE) and its key components (gallic acid, GA; methyl gallate, MG; pentagalloyl glucopyranose, PGG) have generated interest because of their pharmacological activities. To develop the potential use in MSKE as natural therapeutic agents, pharmacokinetic data are necessary. Therefore, this study was performed to evaluate factors affecting oral bioavailability pure compounds MSKE. The vitro chemical stability, biological absorption were evaluated Hanks’ Balanced Salt...

A microemulsion system containing Thai mango seed kernel extract (MSKE, cultivar "Fahlun") was developed and characterised for the purpose of topical skin delivery. The MSKE-loaded microemulsions were prepared by using spontaneous emulsification method. Isopropyl myristate (IPM) selected as oil phase. polyoxyethylene sorbitan monooleate monododecanoate (1:1, w/w) used surfactant phase; an aqueous mixture different cosurfactants (absolute ethanol, 96.3% v/v 1-propanol, 2-propanol or...

Polyphenols from the extracts of Areca catechu L. and Quercus infectoria Oliv. inhibited phospholipase A2, proteases, hyaluronidase L-amino acid oxidase Naja naja kaouthia Lesson (NK) Calloselasma rhodostoma Kuhl (CR) venoms by in vitro tests. Both hemorrhagic activity CR venom dermonecrotic NK vivo The inhibitory plant polyphenols against local tissue necrosis induced snake may be caused inhibition inflammatory reactions, hemorrhage, necrosis. result implies therapeutic potential snakebite victims.

Pectinate gel beads containing Thai mango seed kernel extract (MSKE, cultivar ‘Fahlun’) were developed and characterised for the purpose of colon-targeted delivery. The MSKE-loaded pectinate prepared using ionotropic gelation with varying pectin-to-MSKE ratios, MSKE concentrations, concentrations two cross-linkers (calcium chloride zinc acetate). formulated spherical in shape ranged size between 1.13 mm 1.88 mm. Zinc-pectinate (ZPG) high amounts showed complete entrapment efficiency (EE)...

The ethyl acetate extract of Eclipta prostrata. L. (Asteraceae) was evaluated for its antivenom potential against Calloselasma rhodostoma. Kuhl (Viperidae) (Malayan pit viper; MPV) venom. partially purified (PEE) found to contain 47% wedelolactone as major constituent. PEE and demonstrated strong antiproteolytic antihemorrhagic activities MPV venom in a dose-dependent manner. extract, at 5 mg/mL, could inhibit proteolytic activity 100 µg the hemorrhagic 3 minimum doses (MHD) 95% 68%,...

The in vitro. venom neutralizing capacity of tannic acid against the activities Naja kaouthia. (Naja naja Lesson [Elapidae]) was investigated. Tannic found to be effective (NK) venom. lethal effect four-times LD50 mice and necrotizing one minimum dose (1 MND) rats NK were fully inhibited by at ≥ 431 µg/mouse, with median (ED50) 334 µg/mouse 30 µg/rat, respectively. acetylcholinesterase activity almost completely neutralized (≥ 99%) 1% w/v. It evident that nontoxic did not cause either a (at...