A5077273334- Parkinson's Disease Mechanisms and Treatments
- Gene expression and cancer classification
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Cloud Computing and Resource Management
- Genomics and Phylogenetic Studies
- Video Surveillance and Tracking Methods
- Animal Disease Management and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Neurotransmitter Receptor Influence on Behavior
- Mitochondrial Function and Pathology
- Viral gastroenteritis research and epidemiology
- Receptor Mechanisms and Signaling
- Coronary Interventions and Diagnostics
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Machine Learning in Bioinformatics
- Data Mining Algorithms and Applications
- Cardiovascular Disease and Adiposity
- Remote Sensing and Land Use
- Endoplasmic Reticulum Stress and Disease
- Graph Theory and Algorithms
- Nuclear Receptors and Signaling
- Advanced Data Storage Technologies
Anhui University
2024
South China Agricultural University
2021-2024
Key Laboratory of Guangdong Province
2021-2024
Argonne National Laboratory
2024
Second Affiliated Hospital of Zhejiang University
2019-2023
Jilin University
2012-2023
First Affiliated Hospital of Jiamusi University
2023
Capital Medical University
2016-2022
Jilin Medical University
2021
Beijing Tian Tan Hospital
2020
Abstract Microglial hyperactivation of the NOD‐, LRR‐, and pyrin domain‐containing 3 (NLRP3) inflammasome contributes to pathogenesis Parkinson's disease (PD). Recently, neuronally expressed NLRP3 was demonstrated be a Parkin polyubiquitination substrate driver neurodegeneration in PD. However, role activation microglia remains unclear. Thus, we aimed investigate whether regulates microglia. We investigated through overexpression BV2 microglial cells knockout primary after lipopolysaccharide...
Inflammasome-induced neuroinflammation is a key contributor to the pathology of Parkinson's disease (PD). NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation has been implicated in PD postmortem human brains, indicating it as potential target for treatment. Melatonin, multitasking molecule, found have anti-inflammatory activities, mediated by silence information regulator 1 (SIRT1). However, whether and how melatonin involved inflammasome-induced pathogenesis remains...
Inflammasome activation has a pathogenic role in Parkinson's disease (PD). Up-regulated expressions of inflammasome adaptor apoptosis-associated speck-like protein containing CARD (ASC) and assembly ASC specks have been observed postmortems human PD brains experimental models. Extracellular behave like danger signals sustain prolonged activation. However, the contribution propagation pathological progression not fully established.Herein, we used A53T mutant α-synuclein preformed fibrils...
Clouds and MapReduce have shown themselves to be a broadly useful approach scientific computing especially for parallel data intensive applications. However they limited applicability some areas such as mining because has poor performance on problems with an iterative structure present in the linear algebra that underlies much analysis. Such can run efficiently clusters using MPI leading hybrid cloud cluster environment. This motivates design implementation of open source Iterative system...
Peste des petits ruminants (PPR) is a highly contagious infectious disease of goats, sheep and small wild ruminant species with high morbidity mortality rates. The virus (PPRV) expresses hemagglutinin (H) glycoprotein on its outer envelope that crucial for viral attachment to host cells represents key antigen inducing the immune response.To determine whether H can be exploited generate an effective PPRV vaccine, replication-competent recombinant canine adenovirus type-2 (CAV-2) expressing...
Patients with Alzheimer's disease (AD) have a significantly higher risk of seizures than other individuals in an age-matched population, suggesting close association between epilepsy and AD. We aimed to examine the effects levetiracetam (LEV)-a drug for treating seizures-on learning memory neuropathological features AD.We crossbred APP23 mice microtubule-associated protein tau (MAPT) transgenic generate APP23/MAPT mice. These were treated different concentrations LEV presence kainic acid...
Kainic acid (KA) treatment causes neuronal degeneration, which is a feature of Alzheimer's disease (AD) symptoms such as amyloid β-protein production and memory deficits. Inflammasomes are known to be critical for the progression AD. However, underlying mechanism by inflammasomes influence AD remains unknown. The present study investigated damaging effect KA on neurons focusing inflammasome-mediated signaling pathways. Assessments using cultured microglia mouse brains demonstrated that...
MapReduce has been adopted widely in both academia and industry to run large-scale data parallel applications. In MapReduce, each slave node hosts a number of task slots which tasks can be assigned. So they limit the maximum that execute concurrently on node. When all are not used, resources "reserved" for idle unutilized. To improve resource utilization, we propose stealing enable running steal reserved give them back proportionally whenever new Resource makes otherwise wasted get fully...
Many scientific applications suffer from the lack of a unified approach to support management and efficient processing large-scale data. The Twister MapReduce Framework, which not only supports traditional programming model but also extends it by allowing iterations, addresses these problems. This paper describes how is applied several kinds such as BLAST, MDS Interpolation GTM in non-iterative style without interpolation an iterative style. results show applicability data parallel EM...
Big data processing tools have evolved rapidly in recent years. MapReduce has proven very successful but is not optimized for many important analytics, especially those involving iteration. In this regard, Iterative frameworks improve performance of job chains through caching. Further, Pregel, Giraph and Graph Lab abstract as a graph process it iterations. But all these are designed with fixed abstraction limited collective communication support to synchronize application algorithm control...
The compound 3β, 16β, 17α‑trihydroxycholest‑5‑en‑22‑one 16‑O‑(2‑O‑4‑methoxybenzoyl‑β‑D‑xylopyranosyl)‑ (1→3)‑(2‑O‑acetyl‑α‑L‑arabinopyranoside (OSW‑1) is a member of the cholestane saponin family that was created in bulbs Ornithogalum saudersiae. OSW‑1 has previously been shown as cytotoxic against numerous types malignant cells, however, its antitumoral mechanisms remain unclear. present study aimed to examine potential changes gene expression hepatocellular carcinoma (HCC) cell line...
Striatal adenosine A2A receptors (A2ARs) modulate striatal synaptic plasticity and instrumental learning, possibly by functional interaction with the dopamine D2 (D2Rs) metabotropic glutamate 5 (mGluR5) through receptor-receptor heterodimers, but in vivo evidence for these interactions is lacking. Using situ proximity ligation assay (PLA), we studied subregional distribution of A2AR-D2R A2AR-mGluR5 heterodimer complexes striatum their adaptive changes over random interval ratio training...
The balance and smooth shift between flexible, goal-directed behaviors repetitive, habitual actions are critical to optimal performance of behavioral tasks. striatum plays an essential role in control versus through a rich interplay the numerous neurotransmitters neuromodulators modify input, processing output functions striatum. adenosine receptors (namely A2AR A1R), with their high expression pattern abilities interact integrate dopamine, glutamate cannabinoid signals striatum, may...
The recent advance in next generation sequencing (NGS) techniques has enabled the direct analysis of genetic information within a whole microbial community, bypassing culturing individual species lab. One can profile marker genes 16S rRNA encoded sample through amplification highly variable regions and them by using Roche/454 sequencers to generate half few millions fragments about 400 base pairs. main computational challenge analyzing such data is group these sequences into operational...
The excitotoxicity induced by kainic acid (KA) is thought to contribute the development of Alzheimer's disease (AD); however, mechanisms underlying this remain unknown.In current study, we investigated dynamic changes in tau phosphorylation and their associations with intraperitoneal injection KA mouse brain.We found that KA-induced led sustained hyperphosphorylation MAPT transgenic (Tg) mice.By using cultured microglia brains, showed treatment specifically endoplasmic reticulum (ER) stress,...
Due to their high-speed, correlation filters for object tracking have begun receive increasing attention. Traditional trackers based on typically use a single type of feature. In this paper, we attempt integrate multiple feature types improve the performance, and propose new DD-HOG fusion that consists discriminative descriptors (DDs) histograms oriented gradients (HOG). However, features as multi-vector cannot be directly used in prior filters. To overcome difficulty, filter (MVCF) can...
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, and mainly characterized by progressive degeneration dopaminergic (DA) neurons in midbrain substantia nigra non-DA many other parts brain. Previous studies have shown that several genes associated with causes PD can influence neurite outgrowth. Mutations PRKN (encoding parkin, an E3 ubiquitin ligase) are frequent cause recessively inherited PD. The lack a phenotype Prkn-knockout mice may imply unique...