A5100429248- Gut microbiota and health
- Antimicrobial Peptides and Activities
- Pharmaceutical and Antibiotic Environmental Impacts
- Aquaculture disease management and microbiota
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Dermatological diseases and infestations
- Parasitic Infections and Diagnostics
- Retinoids in leukemia and cellular processes
- Immune Cell Function and Interaction
- Protein Hydrolysis and Bioactive Peptides
Shanghai Medical College of Fudan University
2021
Fudan University Shanghai Cancer Center
2021
South China Agricultural University
2019-2020
South China Botanical Garden
2020
China Agricultural University
2016-2017
Boston Children's Hospital
2014
Background: Targeted therapeutic strategies for advanced colorectal cancer (CRC) have been limited. STING is crucial to the antitumor immunotherapy, it stimulates IFN signaling mediate crosstalk between innate and adaptive immune responses. Emerging evidence suggests that also contributes prognosis of CRC. However, prognostic models relating not yet explored. Methods: A total 431 CRC samples from TCGA database were analyzed explore value STING-related genes. We trained using multivariate Cox...
Our previous studies have shown that vitamin A (VA) status is associated with antiviral immunity and pathogenic conditions in enterovirus 71 (EV71)-infected children. In the present study, we established an vitro model to investigate effects potential mechanism of activity VA. Human monocytic U937 cells were cultured infected EV71. All-trans-retinoic acid (ATRA), active metabolite VA, Ro 41-5253, a retinoic receptor-α (RAR-α) antagonist, used as experimental treatment agents. The percentage...
Abstract Background: Antimicrobial resistance has become a global problem that poses great threats to human health. Antimicrobials are widely used in broiler chicken production and consequently affect the fecal resistome. Here we metagenomic approach investigate effects of pulsed antimicrobial administration on Chickens received three 5-day-course alone/combined antimicrobials at therapeutic dose, including amoxicillin, chlortetracycline florfenicol. Chicken feces was collected T0 (before...
Abstract Background Chlortetracycline is widely used for disease treatment and prevention in animal production system. However, the impact of chlortetracycline on gastrointestinal tract microbial communities growing chickens has not been fully explored. Results Chickens received 5-day-course at actual therapeutic dose/low doses. By using 16S-rRNA sequencing-based approach, We found predominant Firmicutes Oscillospira significantly increased, while Shigella decreased therapeutic-dose group....