A5091273877- Sleep and Wakefulness Research
- Bipolar Disorder and Treatment
- Sleep and related disorders
- Circadian rhythm and melatonin
- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Eating Disorders and Behaviors
- Peroxisome Proliferator-Activated Receptors
- Youth Substance Use and School Attendance
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Fatty Acid Research and Health
- Dietary Effects on Health
- Mental Health Research Topics
Douglas Mental Health University Institute
2017-2025
McGill University
2017-2025
Centre Hospitalier de l’Université de Montréal
2024-2025
HEC Montréal
2023
Infradian mood and sleep-wake rhythms with periods of 48 hours beyond have been observed in patients bipolar disorder (BD), which even persist the absence exogenous timing cues, indicating an endogenous origin. Here, we show that mice exposed to methamphetamine drinking water develop infradian locomotor extend sleep length manic state–associated behaviors support a model for cycling BD. The capacity is abrogated upon genetic disruption dopamine (DA) production DA neurons ventral tegmental...
Abstract Background Sleep problems are common in eating disorders (EDs). Purpose We evaluated whether sleep-phasing regularity associates with the of daily events. Methods ED patients (n = 29) completed hourly charts mood and occasions for 2 weeks. Locomotor activity was recorded continuously by wrist actigraphy a minimum 10 days, sleep calculated based on periods inactivity. computed center inactivity (CenDI) as measure phasing consolidation (ConDI) rhythm strength. assessed interday...
ABSTRACT The symptomatology of Alzheimer’s disease (AD) includes cognitive deficits and sleep disturbances. Recent findings suggest the involvement dysfunctions in lipid metabolism, such as oleic acid build-up, brain AD patients animal models. In addition, inhibition stearoyl-CoA desaturase (SCD), a lipid-converting enzyme, was shown to restore memory triple transgenic (3xTg)-AD mice. brain, astrocytes regulate synthesis specific lipids. Alterations their function were reported models, have...
Objective: We present novel dimensional methods to describe the timing of eating in psychopathology. focused on relationship between current mood bipolar disorder (BD) and stability temporal pattern daily events.Methods: Consenting BD patients (n = 69) from an outpatient, tertiary care clinic completed hourly charts for two weeks. Mood was also evaluated with Montgomery-Åsberg Depression Rating Scale (MADRS) Young Mania (YMRS).Results: Illustrative displays, or eatograms, enabling...
Objective: Bipolar disorder (BD) confers elevated suicide risk and associates with misaligned circadian rhythm. Real-time monitoring of objectively measured sleep is a novel approach to detect prevent suicidal behavior. We aimed at understanding associations between subjective insomnia actigraphy data severity ideation in BDs. Methods: This prospective cohort study comprised 76 outpatients BD aged 18 65 inclusively. Main measures included 10 consecutive days wrist actigraphy; the Athens...
Abstract Background Sleep problems are common in bipolar disorders (BDs). To objectively characterize these BDs, further methodological development is needed to capture subjective insomnia. Aim test psychometric properties of the Athens Insomnia Scale (AIS), and associations with actigraphy‐derived measures, applying modifications actigraphy data processing features perturbed sleep patients a BD. Methods Seventy‐four completed AIS Quick Inventory Depressive Symptomatology, self‐report...
Infradian mood and sleep-wake rhythms with periods of 48 hr beyond have been observed in bipolar disorder (BD) subjects that even persist time isolation, indicating an endogenous origin. Here we show mice exposed to methamphetamine (Meth) drinking water develop infradian locomotor which extend sleep length mania-like behaviors support a model for cycling BD. This capacity is abrogated upon genetic disruption DA production neurons the ventral tegmental area (VTA) or ablation nucleus accumbens...