A5006930844- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Birth, Development, and Health
- Per- and polyfluoroalkyl substances research
- Telomeres, Telomerase, and Senescence
- Gestational Diabetes Research and Management
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Traditional Chinese Medicine Analysis
- Health, Environment, Cognitive Aging
- Lipid metabolism and disorders
- Heavy Metal Exposure and Toxicity
- Esophageal Cancer Research and Treatment
- Atmospheric Ozone and Climate
- Medicinal Plant Pharmacodynamics Research
- Urinary and Genital Oncology Studies
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
Guangxi Medical University
2019-2024
Aim Liver‐specific non‐coding RNAs have been reported to play crucial roles in hepatocellular carcinoma (HCC). We investigated the possible biological performance of a novel liver‐specific long RNA, LINC02499, HCC. Methods The association between LINC02499 expression and HCC was evaluated based on Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases, then confirmed cohort by quantitative real‐time polymerase chain reaction. effects cells were verified gain‐ loss‐of‐function...
Abstract Background Long non-coding RNAs (lncRNAs) are involved in the development of hepatocellular carcinoma (HCC). We aimed to investigate function LINC01146 HCC. Methods The expression HCC tissues was explored via Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases verified using quantitative real-time polymerase chain reaction (qRT–PCR) our cohort. Kaplan–Meier analysis used assess relationship between prognosis patients. Cell Counting Kit 8, colony formation assays,...
Increasing evidence shows that liver-specific long non-coding RNAs (lncRNAs) play important roles in the development of hepatocellular carcinoma (HCC). We identified a novel lncRNA, FAM99A, and examined its clinical significance biological functions HCC.The expression level value FAM99A HCC were using The Cancer Genome Atlas (TCGA), International Consortium (ICGC), Gene Expression Omnibus (GEO) databases, further verified quantitative real-time polymerase chain reaction (qRT-PCR) our cohort....
Abstract Background Telomere length (TL) is variable at birth and inversely associated with body mass index (BMI) in adulthood. A growing number of evidences suggested that a higher maternal pre-pregnancy BMI results adverse offspring health outcomes, especially shorter newborn TL. However, newborn’s genetic endowment equally derived from both parents, the association between parental TL has been rarely discussed. We aimed to determine Methods total 1082 parent-newborn pairs were recruited...
Objective: To investigate the effect of esculin on proliferation triple negative breast cancer cells and its molecular mechanism. Methods: MDA-MB-231 were treated with 28, 56, 112, 225, 450 900 μmol/L for 24, 48 72 h, respectively, cell viability was detected by counting kit 8 (CCK-8) assay. In addition, 0, h. And then changes in morphology observed inverted microscope. The clone-forming ability colony formation mRNA expression levels FBI-1, p53 p21 using real-time fluorescence quantitative...
Background: Circular RNAs (circRNAs) have been demonstrated to be closely related the carcinogenesis of human cancer in recent years. However, molecular mechanism circRNAs pathogenesis hepatocellular carcinoma (HCC) has not fully elucidated. We aimed identify critical and explore their potential regulatory network HCC. Methods: The robust rank aggregation (RRA) algorithm weighted gene co-expression analysis (WGCNA) were conducted unearth differentially expressed (DEcircRNAs) expression...
Aim: To explore the expression profiles and functions of circRNAs in hepatocellular carcinoma (HCC). Materials & methods: We obtained circRNA through RNA sequencing. Expression levels were confirmed by quantitative real-time PCR. The effects on HCC progression determined using Cell Counting Kit 8, clone formation transwell assays. Results: identified 114 upregulated 144 downregulated tissues. results PCR showed that circGNAO1, circRNF180 circMERTK significantly tissues, whereas circSNX6 was...
Abstract Background: Telomere length (TL) is variable at birth and inversely associated with body mass index (BMI) in adulthood. A growing number of evidences suggested that a higher maternal pre-pregnancy BMI results adverse offspring health outcomes, especially shorter newborn TL. However, newborn’s genetic endowment equally derived from both parents, the association between parental TL has been rarely discussed. We aimed to determine Methods: total 1082 parent-newborn pairs were recruited...
Aim: To explore the expression profiles of long noncoding RNAs (lncRNAs) and identify novel lncRNAs as biomarkers for early diagnosis therapy hepatocellular carcinoma (HCC). Materials & methods: Expression mRNAs in five paired HCC adjacent normal tissues were obtained by RNA sequencing. Eight lncRNAs, including two liver-specific (NONHSAT059247.2 NONHSAT013897.2), validated another 74 pairs quantitative reverse transcription PCR. Results: The results PCR showed that NONHSAT252133.1,...
Abstract BackgroundLong non-coding RNAs (lncRNAs) have been proven to be involved in the development of hepatocellular carcinoma (HCC). We aimed investigate function LINC01146 HCC.MethodsThe expression HCC tissues was explored via Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, verified using quantitative real-time polymerase chain reaction (qRT-PCR) our cohort. Kaplan-Meier analysis used assess relationship between prognosis patients. Cell Counting Kit 8, colony...