A5078072950- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Advanced Antenna and Metasurface Technologies
- Antenna Design and Analysis
- MicroRNA in disease regulation
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Metamaterials and Metasurfaces Applications
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- Circular RNAs in diseases
- Microwave Engineering and Waveguides
- Microbial Metabolism and Applications
- Acute Ischemic Stroke Management
- Endometrial and Cervical Cancer Treatments
- Ferroptosis and cancer prognosis
- Bioinformatics and Genomic Networks
- Galectins and Cancer Biology
- Glutathione Transferases and Polymorphisms
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- S100 Proteins and Annexins
Dali University
2012-2025
Dalian Medical University
2023-2025
First Affiliated Hospital of Dalian Medical University
2023-2025
Air Force Engineering University
2010-2024
Shanghai Changzheng Hospital
2024
Health First
2024
Bridge University
2024
Zhengzhou University
2024
Yunnan University
2023
Shanghai East Hospital
2014-2021
The Cancer Genome Atlas (TCGA) has accrued RNA-Seq-based transcriptome data for more than 4000 cancer tissue samples across 12 types, translating these into biological insights remains a major challenge. We analyzed and compared the transcriptomes of 4043 548 normal from 21 TCGA created comprehensive catalog gene expression alterations each type. By clustering genes co-regulated sets, we identified seven cross-cancer signatures altered diverse panel primary human samples. A 14-gene signature...
Anti-tuberculosis drugs remain as an important cause of drug-induced liver injury (DILI) worldwide. Adverse drug reactions reduce the effectiveness treatment. We aimed to determine incidence and risk factors associated with anti-tuberculosis DILI (ATDILI).Using established criteria causality assessment methods, for ATDILI were identified in a contemporary cohort validated another prospectively. Independent determinants using Cox regression analysis.In derivation (n = 3155), 170 (5.4%)...
Abstract Immune and inflammatory responses have an important function in the pathophysiology of pulmonary hypertension (PH). However, little is known about immune landscape peripheral circulation patients with high-altitude (HAPH). We apply single-cell transcriptomics to characterize monocytes that are significantly enriched blood mononuclear cells (PBMC) HAPH patients. discover increase C1 (non-classical) C2 (intermediate) PBMCs a decrease hypoxia-inducible transcription factor-1α (HIF-1α)...
<title>Abstract</title> Lung cancer is a primary malignant tumor of the lung that poses greatest health risk to population. An immune-associated protein family gene called T-cell immunoglobulin and mucin domain 1 (TIM-1) can be utilized as an immunological marker help diagnose cancer. However, correlation between TIM-1 polymorphisms has not been reported, so present study focused on genotyping polymorphic loci (rs1501909, rs2036402, rs2270924, rs870581) by TaqMan probe assay, aim was...
Baculovirus inhibitory of apoptosis repeat-containing 5 (BIRC5) is critically implicated in various types tumors. However, the specific mechanisms by which it operates glioma are yet to be fully understood. The data sourced from Cancer Genome Atlas and Gene Expression Omnibus were merged analyzed using R software investigate relationship between BIRC5 expression prognosis diagnosis outcomes. This exploration was conducted utilizing biological information repositories. correlation immunity...
High altitude polycythemia (HAPC) is a disease with high morbidity and great harm in populations. It has been shown that Single Nucleotide Polymorphisms (SNPs) correlate the genetic basis of adaptation to plateau hypoxia Tibetan The EPAS1 PPARA genes are involved by encoding transcription factors populations at altitude. aim this study was investigate association gene locus polymorphisms susceptibility HAPC Chinese population. We included 78 patients 84 healthy controls, genotyped SNP loci...
One of the biggest public health issues facing globe today is pancreatic cancer (PC). To serve as a guide for clinically identifying existing research hotspots and conducting related studies in future, bibliometric visualization analyses literature on risk factors PC prevention were carried out this work. Results published from 2004 to 2024 retrieved using Web Science database search platform. CiteSpace VOSviewer used visual analysis. Based exclusion criteria, 868 articles all screened....
In order to investigate the gene expression patterns and molecular regulatory mechanisms of obstructive sleep apnea hypopnea syndrome (OSAHS), global transcriptome profiles OSAHS patients healthy people were analyzed using sequencing technology. Differential circular RNA, microRNA, long noncoding messenger RNA was investigated between two groups. To further explore role differentially expressed genes in OSAHS, we functionally annotated enrichment analysis GO KEGG pathways. Finally, ceRNA...
Hypoxia-inducible factor 1 A (HIF1A) is considered as a potential marker gene for ischemic stroke (IS), its polymorphism may affect IS risk and be related to the pathological process. In this study, total of 159 patients 141 healthy controls were enrolled by case-control study method. HIF1A three single nucleotide polymorphisms (SNPs: rs10873142, rs11549465, rs11549467) genotyped SNaPshot method protein levels was detected enzyme-linked immunosorbent assay (ELISA), then correlation between...
<title>Abstract</title> Background and Purpose MicroRNAs (miRNAs) play multifaceted roles in cervical cancer therapy, including regulating progression, metastasis, drug resistance, HPV control, metabolic alterations. This study aims to provide a comprehensive bibliometric analysis of the existing literature on miRNAs cancer, offering insights into research trends, key contributors, emerging themes guide future investigations enhance therapeutic strategies. Method We conducted systematic...
Stroke is a serious cardiovascular disease, major cause of disability and death in both developed developing countries. Superoxide dismutases (SODs) are enzymes that catalyze the breakdown superoxide into oxygen hydrogen peroxide play key role antioxidant response. This study explored relationship between single-nucleotide polymorphisms (SNPs) SOD genes risk ischemic stroke (IS) Chinese Han population Dali City.For this case-control study, authors enrolled 144 patients who had an IS 128...
BackgroundEteplirsen (Exondys 51) is an orphan drug approved for the treatment of Duchenne muscular dystrophy (DMD), having received accelerated approval from U.S. Food and Drug Administration (FDA) in 2016. The primary aim this study to closely monitor adverse events (AEs) associated with eteplirsen identify emerging signals better characterize their safety profile.MethodsAEs due usage reported third quarter (Q3) 2016 fourth (Q4) 2023 were collected FDA Adverse Event Reporting System...
Stroke is a sudden cerebrovascular circulatory disorder with high morbidity, disability, mortality, and recurrence rate, but its pathogenesis key genes are still unclear. In this study, bioinformatics was used to deeply analyze the of stroke related genes, so as study potential provide guidance for clinical treatment. Gene Expression profiles GSE58294 GSE16561 were obtained from Omnibus (GEO), differentially expressed (DEGs) identified between IS normal control group. The different...
Global cerebral ischemia (GCI), a consequence of cardiac arrest (CA), can significantly damage the neurons located in vulnerable hippocampus CA1 areas. Clinically, neurological injury after CA contributes to death most patients. Mastoparan-M extracted from Vespa magnifica (Smith) be used treat major disorders. Hence, this study aimed assess effects on GCI.To evaluate neurotoxicity and neuroprotective effect Mastoparan-M, CCK8 Annexin V-FITC/PI apoptosis assays were first performed...
Endometriosis is associated with ovarian cancers, mainly endometrioid and clear-cell carcinomas. Iron metabolism has been shown to play a role in endometriosis. Therefore, it vital explore the relationship between iron cancer identify novel markers for diagnostics therapeutics. The endometriosis dataset GSE51981 GSE26712 were obtained from gene expression omnibus database, differentially expressed genes identified. molecular signatures hub 3 datasets obtained. Seven identified by...
Abstract Hepatocellular carcinoma (HCC) is a common malignant tumour with high rates of morbidity and mortality worldwide. Therefore, it great significance to find new molecular markers for HCC diagnosis treatment. G6PD known be dysregulated in variety tumours. In addition, the ceRNA network plays crucial role occurrence development HCC. However, mechanism by which regulates remains unclear. We used TCGA-LIHC data analyse possibility using as an independent prognostic marker. Univariate Cox...
Ischemic strokes (ISs) are commonly treated by intravenous thrombolysis using a recombinant tissue plasminogen activator; however, successful treatment can only occur within 3 hours after the stroke. Therefore, it is crucial to determine causes and underlying molecular mechanisms, identify biomarkers for early diagnosis, develop precise preventive treatments strokes. We aimed clarify differences in gene expression, drug prediction approaches between IS myocardial infarction (MI)...
Pancreatic cancer (PC) is a malignant tumour with poor prognosis and high mortality, fasting plasma glucose (HFPG) considered to be one of its important risk factors.
Ischemic stroke (IS) is the most common cardiovascular and cerebrovascular disease in clinic. Qiangli Tianma Duzhong Capsule (TMDZ capsule) has significant therapeutic effect to IS. Therefore, it great significance explore mechanism of action TMDZ capsules treatment IS.The potential active components possible targets capsule were obtained from TCMSP The Encyclopedia Traditional Chinese Medicine databases. IS related collected by Genecard database, OMIM TTD database DisGeNET database. target...
The design simulation and measurement of a highly miniaturized compound spiral antenna is presented. designed by combining typical equiangular with new terminals. Favorable wideband properties are shown in the simulated measured results. return loss less than -10 dB frequency range from 1.6 to 10 GHz axial ratio much 3 between 1.2 GHz, significantly proposed has 44.8% reduction at lower operating comparison same size.