A5046074980- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Essential Oils and Antimicrobial Activity
- Piperaceae Chemical and Biological Studies
- Phytochemicals and Antioxidant Activities
- Andrographolide Research and Applications
- Ginger and Zingiberaceae research
- African Botany and Ecology Studies
- Synthesis and biological activity
- Food Chemistry and Fat Analysis
- Plant Pathogenic Bacteria Studies
- Proteins in Food Systems
- Synthesis and Biological Evaluation
- Phytochemical compounds biological activities
- Saffron Plant Research Studies
- Phytochemistry and biological activities of Ficus species
- Conservation, Biodiversity, and Resource Management
- Seed and Plant Biochemistry
- Indigenous Knowledge Systems and Agriculture
- Synthesis of heterocyclic compounds
- Plant biochemistry and biosynthesis
- Metabolism and Genetic Disorders
- Gout, Hyperuricemia, Uric Acid
- Coconut Research and Applications
Forest Research Institute Malaysia
2008-2023
Universiti Teknologi MARA System
2013-2014
Universiti Teknologi MARA
2013
Muntingia calabura L. (Muntingiaceae) is locally known as kerukup siam. Its leaves, flowers, barks and roots have been used traditionally in East Asia South America to treat various diseases including ulcer-related diseases. The present study aimed investigate the mechanism(s) of gastroprotective effect methanol extract leaves (MEMC) using pylorus ligation induced gastric ulceration rats. Five groups rats (n=6) were administered orally once daily for 7 days with 8% Tween 80 (negative...
The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes oxidation of unsaturated fatty acids, such linoleic acid form hydroperoxides. search for selective inhibitors may provide new therapeutic approach diseases. Herein, we report synthesis tHGA analogs using simple...
The crude extracts and isolated compounds of Piper porphyrophyllum (Piperaceae) were evaluated for antibacterial anti-inflammatory activities. ethyl acetate extract 3′,4′,5,7-tetramethoxyflavone exhibited the highest activity against Staphylococcus aureus giving values MIC = 62.5 250 μg/mL, respectively. 5-Hydroxy-7-methoxyflavanone 4′,5-dihydroxy-3′,7-dimethoxyflavone active Pseudomonas aeruginosa, both with value 125 μg/mL. hexane gave in vitro quantitative lipoxygenase inhibition assay...
A new series of 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) analogues were synthesized and evaluated for their lipoxygenase (LOX) inhibitory activity. Prenylated 4a⁻g (half maximal concentration (IC50) values ranging from 35 μ M to 95 M) did not exhibit better activity than tHGA (3a) (IC50 value: 23.6 due the reduction in hydrophobic interaction when alkyl chain length was reduced. One geranylated analogue, 3d, with an IC50 value 15.3 M, exhibited LOX compared (3a), which agreement our...
Preliminary screening study revealed that the methanolic extract of stem T. indica showed xanthine oxidase inhibitory activity in a concentration-dependent manner.EA fraction was selected to be further due its potential inhibit enzyme with IC 50 value 21.14 µg/ml which lower than MeOH extract, 42.02 µg/ml.Further separation and purification EA led isolation two known compounds.Those compounds were identified by analysis their spectroscopic data comparisons literature betulinic acid...
Anti-inflammatory activity of a crude extract Piper magnibaccum (Piperaceae) and compounds isolated from it was established using the TPA-induced mouse ear edema model an in vitro quantitative lipoxygenase inhibition assay. Five were P. [β-sitosterol, N-isobutyl-(2 E,4 E)-tetradecadienamide, linoleic acid, 13-(4′, 5′-dimethoxytridecanoyl)piperidine, piperine]. The light petroleum plant exhibited significant anti-inflammatory both models. E)-tetradecadienamide showed activity, with IE % value...
Before United Nations Convention on Biodiversity (CBD) 1993, documentation of traditional forest related knowledge medicinal plants did not consider much the issue sustainable development and sharing benefits with holders. While some academicians obtained their higher degrees from research local knowledge, indigenous communities providing gained little. With signing CBD, countries have taken efforts to document achieve CBD’s triple objective conserving biological diversity, using natural...
Medicinal plants are a vital source of new bioactive compounds due to their ecological biodiversity and varied chemical properties each species. Phenotypic selection coupled with the evaluation genotypes based on profile can be used for development high-yielding variety. However, most raw material that has been commercial production herbal products is mainly derived from wild sources, little knowledge quality genetic materials. Thus, three medicinal species, Chromolaena odorata (Siam weed),...
With the growing interest in these species as a source of new pharmaceutical products and increasing demand for herbal Malaysia, its raw materials is also increasing. Therefore, initiatives have been taken by Forest Research Institute Malaysia (FRIM) to select produce high quality planting future uses. To our knowledge, most used producing development were being sourced from wild, with little knowledge on materials. In order ensure sustainability market, it important come out suitable...
Dichloromethane extract of the Vitex rotundifolia stems was subjected to in vitro anti-inflammatory tests using xanthine oxidase inhibitory assay and lipoxygenase inhibition assay.The showed 54.6% against NDGA as a positive control however did not exhibit any activity lipoxigenase.Further separation successfully yielded two aldehydic compounds identified 6-hydroxy-4-(4'-hydroxy-3'-methoxyphenyl)-3hydroxymethyl-7-methoxy-3,4-dihydro-2-napthaldehyde...
Three of dihydrochalcone, 2 ',4'-dihydroxy-4,6'-dimethoxydihydrochalcone (1), 2',4',6'-trihydroxy-4-methoxy-dihydrochalcone (2) and uvangoletin (3), were isolated from the chloroform extract leaves Ellipeia cuneifolia.Purification crude was carried out by using various chromatographic techniques such as vacuum column.The structures these compounds elucidated based on spectroscopic methods NMR (1D 2D), LCMS, UV, IR comparison with published data.