How the prefrontal cortex contributes to working memory remains controversial, as theories differ in their emphasis on its role storing memories versus controlling content. To adjudicate between these competing ideas, we tested how perturbations human (both sexes) lateral impact storage and control aspects of during a task that requires subjects allocate resources items based behavioral priority. Our computational model made strong prediction disruption this process would counterintuitively...

The brain forms certain deliberative decisions following normative principles related to how sensory observations are weighed and accumulated over time. Previously we showed that these can account for people adapt their the temporal dynamics of (Glaze et al., 2015). Here show this adaptability extends accounting correlations in observations, which have a dramatic impact on weight evidence provided by those observations. We tested online human participants novel visual-discrimination task...

There is growing interest in how neuromodulators shape brain networks. Recent neuroimaging studies provide evidence that brainstem arousal systems, such as the locus coeruleus-norepinephrine system (LC-NE), influence functional connectivity and network topology, suggesting they have a role flexibly reconfiguring networks order to adapt behavior cognition environmental demands. To date, however, relationship between systems has not been assessed within context of task with an established...

In the cognitive domain, enormous variation in methodological approach prompts questions about generalizability of behavioral findings obtained from studies transcranial direct current stimulation (tDCS). To determine impact common variations approach, we systematically manipulated two key parameters—current polarity and intensity—and assessed their on a task inhibitory control (the Eriksen Flanker). Ninety participants were randomly assigned to one nine experimental groups: three conditions...

ABSTRACT How the prefrontal cortex contributes to working memory remains controversial, as theories differ in their emphasis on its role storing memories versus controlling content. To adjudicate between these competing ideas, we tested how perturbations human (both sexes) lateral impact storage and control aspects of during a task that requires subjects allocate resources items based behavioral priority. Our computational model made strong prediction disruption this process would...

Expectations, such as those arising from either learned rules or recent stimulus regularities, can bias subsequent auditory perception in diverse ways. However, it is not well understood if and how these effects depend on the source of expectations. Further, unknown whether different sources use same computational physiological mechanisms. We examined rule-based stimulus-based expectations influenced behavior pupil-linked arousal, a marker certain forms expectation-based processing, human...

The brain forms certain deliberative decisions following normative principles related to how sensory observations are weighed and accumulated over time. Previously we showed that these can account for people adapt their the temporal dynamics of (Glaze et al., 2015). Here show this adaptability extends accounting correlations in observations, which have a dramatic impact on weight evidence provided by those observations. We tested online human participants novel visual-discrimination task...

The brain forms certain deliberative decisions following normative principles related to how sensory observations are weighed and accumulated over time. Previously we showed that these can account for people adapt their the temporal dynamics of (Glaze et al., 2015). Here show this adaptability extends accounting correlations in observations, which have a dramatic impact on weight evidence provided by those observations. We tested online human participants novel visual-discrimination task...

The brain forms certain deliberative decisions following normative principles related to how sensory observations are weighed and accumulated over time. Previously we showed that these can account for people adapt their the temporal dynamics of (Glaze et al., 2015). Here show this adaptability extends accounting correlations in observations, which have a dramatic impact on weight evidence provided by those observations. We tested online human participants novel visual-discrimination task...

Instructions have a powerful effect on learning and decision-making, biasing choice even in the face of disconfirming feedback. Detrimental effects been reported number studies which instruction was given prior to trial-and-error learning. Previous work has attributed individual differences instructional bias variations prefrontal striatal dopaminergic genes, suggesting role for prefrontally-mediated cognitive control processes The current study replicates extends these findings. Human...

Abstract Expectations, such as those arising from either learned rules or recent stimulus regularities, can bias subsequent auditory perception in diverse ways. However, it is not well understood if and how these effects depend on the source of expectations. Further, unknown whether different sources use same computational physiological mechanisms. We examined rule-based stimulus-based expectations influenced behavior pupil- linked arousal, a marker certain forms expectation-based...