A5037417048- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cardiovascular Function and Risk Factors
- RNA regulation and disease
- Adipose Tissue and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Nuclear Receptors and Signaling
- Cardiovascular Disease and Adiposity
- interferon and immune responses
- Cancer-related gene regulation
- Cardiac Ischemia and Reperfusion
- Caveolin-1 and cellular processes
- Cardiac electrophysiology and arrhythmias
Kyoto University
2019-2021
Abstract Adaptive thermogenesis is essential for survival, and therefore tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the brain indispensable adaptive thermogenesis. Cold stress increases miR-33 levels hypothalamus −/− mice are unable to maintain body temperature cold environments due reduced sympathetic nerve activity impaired brown adipose tissue (BAT) Analysis of f/f dopamine-β-hydroxylase ( DBH )-Cre indicates importance Dbh -positive cells....
No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic reticulum stress, maintained adenosine triphosphate levels, ameliorated the in a murine cardiac ischemia injury model. confirmed cardioprotective effect of KUS121 porcine These findings promising...
Background Micro RNA (miR)-33 targets cholesterol transporter ATP -binding cassette protein A1 and other antiatherogenic contributes to atherogenic progression. Its inhibition or deletion is known result in the amelioration of atherosclerosis mice. However, mice lack member miR-33 family, miR-33b, which exists humans large mammals. Thus, precise evaluation comparison responsibilities these 2 miRs during progression has not been reported, although they are essential. Methods Results In this...