A5101414247- Heart Rate Variability and Autonomic Control
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Foot and Ankle Surgery
- Census and Population Estimation
- Cardiovascular and exercise physiology
- Tendon Structure and Treatment
- Survey Methodology and Nonresponse
- Blood Pressure and Hypertension Studies
- HIV-related health complications and treatments
- Parasitic Diseases Research and Treatment
- Orthopedic Surgery and Rehabilitation
- Arsenic contamination and mitigation
- Racial and Ethnic Identity Research
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Cardiac Imaging and Diagnostics
- Musculoskeletal synovial abnormalities and treatments
- Cardiovascular Function and Risk Factors
- Healthcare Policy and Management
- Patient-Provider Communication in Healthcare
- Cardiovascular Syncope and Autonomic Disorders
- Healthcare Systems and Technology
- Conflict of Laws and Jurisdiction
- Thermoregulation and physiological responses
Brigham and Women's Hospital
2020-2024
Harvard University
2021-2024
Michigan State University
2024
Boehringer Ingelheim (United States)
2022-2024
Indiana University – Purdue University Indianapolis
2024
Indiana University School of Medicine
2024
Grand Rapids Community College
2024
West Virginia University
2023
LivaNova (United States)
2022
Prisma Health
2022
We previously reported that hypoxia-mediated reductions in alpha-adrenoceptor sensitivity do not explain the augmented vasodilatation during hypoxic exercise, suggesting an enhanced vasodilator signal. hypothesized beta-adrenoceptor activation contributes to exercise vasodilatation. Fourteen subjects (age: 29 +/- 2 years) breathed gas titrate arterial O(2) saturation (pulse oximetry) 80%, while remaining normocapnic via a rebreath system. Brachial artery and antecubital vein catheters were...
We previously reported that statin myopathy is associated with impaired carbohydrate (CHO) oxidation in fast-twitch rodent skeletal muscle, which we hypothesised occurred as a result of forkhead box protein O1 (FOXO1) mediated upregulation pyruvate dehydrogenase kinase-4 (PDK4) gene transcription. Upregulation FOXO targets known to regulate proteasomal and lysosomal muscle breakdown was also evident. increasing CHO vivo, using the complex (PDC) activator, dichloroacetate (DCA), would blunt...
Abstract Background Protection against COVID-19 from authorized SARS-CoV-2 vaccines diminishes after six months, so it is evident we need a second-generation vaccine that provides durable cross-variant protection through antibody responses and/or T cell to conserved epitopes. CORAL-CEPI (NCT05435027) Phase I study conducted in South Africa evaluating three self-amplifying mRNA (samRNA)-based candidates.Figure 1Vaccine Cassette Design GRT-R914 encodes full length SpikeBeta and epitopes (TCE)...
Abstract: The syndesmosis is a complex joint and plays critical role in ankle stability. Disruption of the most commonly occurs when foot dorsiflexed position, an external rotation force applied. Injuries can be obvious or subtle, appropriate imaging paramount for diagnosis. Weight-bearing radiographs, stress magnetic resonance imaging, weight-bearing computed tomography scans are used to evaluate integrity syndesmosis. Ankle arthroscopy also diagnosis; however, it inherently more invasive....
Strain echocardiography (SE) provides the rate and extent of myocardial segment shortening lengthening. Thus we hypothesized that SE will noninvasively provide estimates velocity (SV) length change (δ L). We compared SE-derived strain (SR) (ϵ) to force/length transducer-derived SV percent δ L in isolated muscle strips at multiple load levels under varying conditions. Electrically stimulated contractions left ventricular ( n = 20) were simultaneously recorded with a transducer (to measure L)...
We previously demonstrated a bimodal distribution of vasodilator responsiveness to adenosine (Ado) infusion in human subjects, despite similar responses exercise between subgroups [subjects responsive Ado (Ado responders) and subjects with blunted nonresponders]). (Martin EA, Nicholson WT, Eisenach JH, Charkoudian N, Joyner MJ. J Appl Physiol 101: 492-499, 2006). A component this difference was attributed larger nitric oxide Ado-mediated vasodilation responders. However, there may also be...
To gain insight into the role of adenosine (Ado) in exercise hyperemia, we compared forearm vasodilation induced by intra-arterial infusion three doses Ado with during workloads handgrip 27 human subjects. We measured blood flow (FBF) using Doppler ultrasound and mean arterial pressure (MAP) via brachial artery catheters calculated vascular conductance (FVC = FBF/MAP) each dose or workload. found that about half subjects demonstrated robust vasodilator responsiveness to both exercise, other...
Agonism of GPR119 is viewed as a potential therapeutic approach for the treatment type II diabetes and other elements metabolic syndrome. During progression previously disclosed candidate 1 through mice toxicity studies, we observed tonic–clonic convulsions in several at high doses. An vitro hippocampal brain slice assay was used to assess seizure liability subsequent compounds, leading identification an aryl sulfone replacement 3-cyano pyridyl group. Subsequent optimization improve overall...
Purpose: The Consortium of Student-Led Eye Clinics (CSLEC), founded in 2021, administered a comprehensive survey to document the types services, most common diagnoses, and follow-up care protocols offered by student-led free vision screening programs (SLFVSP) United States. Methods: An 81-question institutional review board (IRB)-approved was eye clinics from October 1, 2022 February 24, 2023. Results: Sixteen SLFVSPs were included final analysis, which 81% (n = 13) conducted variations...
Background: Climate change poses a substantial threat to human health, and operating rooms (ORs) have an outsized environmental impact. The Program for Research in Sustainable Medicine (PRiSM) designed protocol minor foot ankle surgery intended reduce waste, streamline instrument trays, minimize laundry. We conducted randomized controlled trial compare the carbon footprint of procedures performed using PRiSM vs traditional protocol. Methods: Forty adult patients undergoing foreign body...
Summary In 25 cardiac surgical patients, right ventricular ejection fraction was continuously measured with a new pulmonary artery catheter and transoesophageal echocardiography, scanning the ‘fractional area change’ in standardised transatrial cross section area. Measurements were recorded at three predefined time points (pre‐, intra‐, postoperatively). Both methods compared using Bland‐Altman analysis. Comparing values obtained from those assessed by bias −3.7%, precision of 30.9%. Bias...
In humans, vasoactive intestinal peptide (VIP) may play a role in reflex cutaneous vasodilation during body heating. We tested the hypothesis that nitric oxide (NO)-dependent contribution to active is enhanced skin of subjects with cystic fibrosis (CF), compensating for sparse levels VIP. 2 parallel protocols, microdialysis fibers were placed 11 CF and 12 controls. Lactated Ringer was perfused at one site NG-nitro-L-arginine methyl ester (2.7 mg/ml) second site. Skin blood flow monitored...
Abstract Methanol poisoning has become very uncommon in Australasia with regulations that have reduced its retail availability. This report describes a young tourist who developed sudden onset visual failure and rapid breathing 2 days after ingestion of complimentary local drink called Arrack when travelling Indonesia. She presented to hospital New Zealand severe metabolic acidosis highly toxic methanol level at 17 mmol/L. The cocktail was consumed popular bar but is likely been mixed from...
A prespecified integrated safety analysis was conducted for 3 doravirine (DOR) double-blind trials (Phase IIb: P007 [NCT01632345]; Phase III: DRIVE-FORWARD [NCT02275780] and DRIVE-AHEAD [NCT02403674]). DOR (100 mg) arms from these were compared with darunavir plus ritonavir (DRV+r) in efavirenz (EFV) DRIVE-AHEAD. Background therapies emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) P007; abacavir/lamivudine (ABC/3TC) or FTC/TDF DRIVE-FORWARD; 3TC/TDF EFV The primary endpoint the...
Journal Article The Effects of Questionnaire Design on Reporting Detailed Hispanic Origin in Census 2000 Mail Questionnaires Get access ELIZABETH MARTIN Search for other works by this author on: Oxford Academic Google Scholar Public Opinion Quarterly, Volume 66, Issue 4, February 2002, Pages 582–593, https://doi.org/10.1086/343863 Published: 01 2002
' We previously demonstrated a bimodal distribution of forearm vasodilator responsiveness to adenosine (ADO) infusion in the brachial arteries human subjects. also that ADO receptor antagonism blunted exercise hyperaemia during heavy rhythmic handgripping, but responses exogenous were only responders. In this study, we continued investigating contribution and possible differences between responders non-responders. hypothesized transporter would increase vasodilatation response only, not...
Abstract Background Doravirine (DOR) is a novel non-nucleoside reverse-transcriptase inhibitor (NNRTI). In the phase 3 DRIVE-AHEAD trial in HIV-1-infected treatment-naïve adults, DOR demonstrated noninferior efficacy to efavirenz (EFV) and favorable profiles for neuropsychiatric tolerability lipids at 48 weeks. We present data through week 96. Methods DRIVE- AHEAD (Clinical Trials Registration: NCT02403674) 3, multicenter, double-blind, noninferiority that compared with EFV. Eligible...