A5002384165- Health disparities and outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Gene expression and cancer classification
- Global Health Care Issues
- Nutrition and Health in Aging
- Obesity, Physical Activity, Diet
- Genetic Associations and Epidemiology
- Sleep and related disorders
- Bioinformatics and Genomic Networks
- Consumer Attitudes and Food Labeling
- Nutritional Studies and Diet
- Frailty in Older Adults
- Ferroptosis and cancer prognosis
- Healthcare Systems and Reforms
- Health Promotion and Cardiovascular Prevention
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Vitamin D Research Studies
- Adolescent and Pediatric Healthcare
- Restless Legs Syndrome Research
- Cerebrovascular and Carotid Artery Diseases
- Molecular Biology Techniques and Applications
- Bone health and osteoporosis research
Soochow University
2021-2024
Zhejiang Cancer Hospital
2024
Chinese Academy of Sciences
2024
Abstract Background This study aimed to investigate the associations between ultra-processed food (UPF) consumption and risk of cardiovascular disease all-cause mortality in UK Biobank Cohort. Methods observational prospective evaluated 60 298 participants aged 40 years or older. We used NOVA classification system identify categorize UPF. The among UPF consumption, (CVD) incidence were estimated using multivariable Cox proportional hazards models. Dose–response analysis CVD was performed a...
Abstract Background Although studies have shown that sleep quality (duration) is associated with health-related of life (HRQoL), most these been small-sized and targeted at young middle-aged adults. In addition, few explored the path mechanism disorders leading to impaired HRQoL. Objectives This study aimed determine association between duration HRQoL among elderly in United Kingdom, assess whether depression mediated association, explore role physical activity (PA) association. Methods Data...
Background: Global ultra-processed food (UPF) consumption has risen rapidly. The development and prognosis of depression anxiety remain unclarified. Herein, we aimed to examine the association between UPF incidence progression trajectory anxiety. Methods: In our study, participants were recruited 2006 2010. was expressed as servings, energy ratio, weight ratio. relationships or assessed using Cox proportional hazards model. Multi-state models used explore risks all transitions from a healthy...
Abstract Background Although previous studies have reported an association between multimorbidity and frailty, its direction mechanism remain unclear. This study aimed to investigate the of this association, as well role depression among older Europeans. Methods We used a cross-lagged panel design evaluate temporal relationship frailty depression. Multimorbidity status was assessed by self-reporting 14 chronic diseases. Frailty based on phenotype. The European-Depression Scale (EURO-D)...
Abstract Background This study aimed to assess the activity of apatinib plus toripalimab in second line for patients with advanced gastric or esophagogastric junction cancer (GC/EGJC). Methods In this open-label, phase II, randomized trial, GC/EGJC who progressed after first-line chemotherapy were enrolled and received 250 mg per day 240 on 1 3 weeks (arm A) physician’s choice (PC, arm B). The primary endpoint was 1-year survival rate. Progression-free (PFS), overall (OS), response rate...
Background and aims This study aimed to examine whether the combination of elevated-C-reactive protein (CRP) levels hypertension increased risk stroke among middle-aged elderly Chinese. Methods analysis included 9,821 Chinese participants aged ≥45 years in China Health Retirement Longitudinal Study (CHARLS). Data based on three waves CHARLS were used (2011, 2013, 2015). Multivariable Cox proportional hazards regression models estimate hazard ratios (HRs) with a 95% confidence interval...
Abstract There have been few investigations of cancer prognosis models based on Bayesian hierarchical models. In this study, we used a novel method to screen mRNAs and estimate the effects patients with lung adenocarcinoma. Based identified mRNAs, can build prognostic model combining clinical features, allowing us explore new molecules potential predict The mRNA data ( n = 594) 470) for adenocarcinoma were obtained from TCGA database. Gene set enrichment analysis (GSEA), univariate Cox...
Abstract Although national health-related quality of life population norms had been published based on the EuroQol 5-Dimensions 5-levels scale, China is a vast country with diverse cultural and social development in various regions. Therefore, regional may better reflect health status residents given area. The purpose study was to derive HRQoL norm for adult general southern Jiangsu Province using EQ-5D-5L scale explore potential influencing factors. data were cross-sectional survey...
Abstract Background Although studies have demonstrated associations between sleep quality (SQ) and grip strength (GS) in older adults, the direction underlying mechanisms of this relationship are yet to be better delineated. We aimed longitudinally investigate bidirectional association SQ GS mediating role depression association. Methods Based on 2 nationally representative samples with people aged ≥50 years from China Health Retirement Longitudinal Study (CHARLS; 4 200 participants) English...
Evidence on the association between frailty and quality of life (QoL) is mostly limited to cross-sectional studies. Thus, temporal order potential mechanisms this are largely unknown. Our study examines both directionality role cognition in longitudinal data.
Objective Gastric cancer (GC) is one of the most common tumour diseases worldwide and has poor survival, especially in Asian population. Exploration based on biomarkers would be efficient for better diagnosis, prediction, targeted therapy. Methods Expression profiles were downloaded from Gene Omnibus (GEO) database. Survival-related genes identified by gene set enrichment analysis (GSEA) univariate Cox. Then, we applied a Bayesian hierarchical lasso Cox model prognostic signature screening....
To investigate the relationship between multimorbidity and health-related quality of life (HRQoL), explore effects functional status cognitive function on Chinses elderly behind this relationship.The Multivariate logistic regression Tobit models were used to determine influence HRQoL. Bootstrap analysis was probe mediating moderating role cognition HRQoL.Results 2,887 participants age ≥ 60 years included in analysis, 51.69% had chronic diseases. Stroke (β = -0.190; 95% confidence interval...
In addition to considering the main effects, understanding gene-environment (G × E) interactions is imperative for determining etiology of diseases and factors that affect their prognosis. existing statistical framework censored survival outcomes, there are several challenges in detecting G E interactions, such as handling high-dimensional omics data, diverse environmental factors, algorithmic complications analysis. The effect heredity principle has widely been used studies involving...
The Liyang cohort study on chronic diseases and risk factors monitoring in China (Liyang Study) is a prospective population-based which aims to investigate identify the determinants of most prevalent non-communicable (NCDs) evaluate impact demographic characteristics, lifestyle, dietary habits, cognition, disability NCDs health-related quality life. Between March 2019 June 2020, 10 056 individuals aged ≥18 years were administered baseline survey through multistage cluster random sampling...