A5085841417- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Multiple Sclerosis Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Sexual Differentiation and Disorders
- Plant-Microbe Interactions and Immunity
- Sexuality, Behavior, and Technology
- ATP Synthase and ATPases Research
- Fungal and yeast genetics research
- Mitochondrial Function and Pathology
- Extracellular vesicles in disease
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant nutrient uptake and metabolism
- Genetic Neurodegenerative Diseases
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Gambling Behavior and Treatments
The University of Sydney
2017-2023
Centenary Institute
2017-2020
The University of Queensland
2013-2018
Lomonosov Moscow State University
2015
Research Institute for Bioscience and Biotechnology
2013
Brisbane School of Theology
2013
Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis the central nervous system (CNS). It is unclear whether there a correlation between these and different (OL) states at adult stages. Here, we present bulk single-cell transcriptomics resources providing insights on how transitions occur. We found that post-natal OPCs from brain spinal cord similar transcriptional signatures. Moreover, OPC progeny of E13.5 electrophysiological profiles to...
This article includes examples of confronting language in relation to people living with obesity.1. weight stigma needs stop, 2. improve clarity and reduce barriers better health, 3. more supportive environments society.Under point 1, they recommend: 'Portrayal obesity
Ataxia-telangiectasia (A-T) is a rare genetic disorder caused by loss of function the ataxia-telangiectasia-mutated kinase and characterized predisposition to cancer, pulmonary disease, immune deficiency progressive degeneration cerebellum. As animal models do not faithfully recapitulate neurological aspects, it remains unclear whether cerebellar neurodevelopmental or neurodegenerative phenotype. To address necessity for human model, we first assessed previously published protocol ability...
CTCF is a master regulator of gene transcription and chromatin organisation with occupancy at thousands DNA target sites genome-wide. While essential for cell survival, haploinsufficiency associated tumour development hypermethylation. Increasing evidence demonstrates as key player in several mechanisms regulating alternative splicing (AS), however, the genome-wide impact Ctcf dosage on AS has not been investigated.We examined effect expression five tissues from hemizygous (Ctcf+/-) mice....
It was recently shown that duplications of the RevSex element, located 0.5 Mb upstream SOX9, cause XX-disorder sex development (DSD), and deletions XY-DSD. To explore how a 148 kb duplication could have turned on gonadal SOX9 expression in absence SRY an XX-male, we examined chromatin landscape primary skin fibroblast cultures from index, his duplication-carrier father six controls. The ENCODE project supports notion state maps show overlap between different cell types, i.e., our study...
Consumer Protection Tools (CPTs; e.g., deposit limits, timeouts) are provided by gambling sites to assist customers gamble without harms. We aimed understand how CPTs used, and which customers, is essential determine their effectiveness.We examined the account data of 39,853 (median age = 33 years; 84% male) across six Australian wagering over 1 year (2018/07/01-2019/06/30).Most (83%) did not use any CPTs, with low rates for limits (15.8%), timeouts (0.55%-1.57%), self-exclusion tools...
Summary Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis the central nervous system (CNS). It is unclear whether there a correlation between these and different transcriptional (OL) states at adult stages. Here we present bulk single-cell transcriptomics resource providing insights on how transitions occur. We show that E13.5 populations are not OPCs, exhibiting instead hallmarks of neural progenitors. A subset progenitors, which refer...
MicroRNAs (miRNAs) are highly conserved ∼22 nt small noncoding RNAs that bind partially complementary sequences in target transcripts. regulate both translation and transcript stability, play important roles development, cellular homeostasis, disease. There limited approaches available to agnostically identify microRNA targets transcriptome-wide, methods using miRNA mimics, which principle direct miRNA:transcript pairs, have low sensitivity specificity. Here, we describe a novel method...
The yeast cell wall is constantly remodeled to enable growth and division. In this study, we describe a novel type of modification. We report that the drug amiodarone induces rapid channel formation within Hansenula polymorpha. Light microscopy shows shortly after adding amiodarone, spherical structures, which can be stained with DNA binding dyes, form on surface. Electron microphotographs show channels 50-80 nm in diameter appear filled intracellular material. Using fluorescent microscopy,...
RNA from human iPS-derived neurons was hybridized to the NCode microarray, which contains probes for over 17 000 putative lncRNAs and protein-coding genes. Values in table represent significantly differentially expressed (B-value > 3, log2-fold change 0.5 or <-0.5). qPCR validation of two ncRNAs down-regulated response activity (Gomafu, Neat1) is shown at right, with levels ncRNA Malat1 remaining unchanged.
Abstract CTCF is a master regulator of gene transcription and chromatin organization with occupancy at thousands DNA target sites. essential for embryonic development somatic cell viability has been characterized as haploinsufficient tumor suppressor. Increasing evidence demonstrates key player in several alternative splicing (AS) regulatory mechanisms, including elongation, regulation factors, epigenetic regulation. However, the genome-wide impact Ctcf dosage on AS not investigated. We...