A5073816266- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Bacteriophages and microbial interactions
- Supramolecular Self-Assembly in Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Lipid Membrane Structure and Behavior
- Nanopore and Nanochannel Transport Studies
- Perovskite Materials and Applications
- Optical properties and cooling technologies in crystalline materials
- Protein Structure and Dynamics
- Quantum Dots Synthesis And Properties
- RNA modifications and cancer
- Chalcogenide Semiconductor Thin Films
- Astronomical Observations and Instrumentation
- Chemical Synthesis and Analysis
- Solid-state spectroscopy and crystallography
- Astrophysical Phenomena and Observations
- Supramolecular Chemistry and Complexes
- Microbial Metabolic Engineering and Bioproduction
- CRISPR and Genetic Engineering
- Luminescence and Fluorescent Materials
- Advanced Biosensing Techniques and Applications
St. Jude Children's Research Hospital
2023-2025
King's College London
2021-2023
University of Cambridge
2016-2019
Imperial College London
2018
University of Copenhagen
2018
Metal halide perovskite crystal structures have emerged as a class of optoelectronic materials, which combine the ease solution processability with excellent optical absorption and emission qualities. Restricting physical dimensions crystallites to few nanometers can also unlock spatial confinement effects, allow large spectral tunability high luminescence quantum yields at low excitation densities. However, most promising rely on lead cationic species, thereby hindering commercial...
Biological cells display complex internal architectures with distinct micro environments that establish the chemical heterogeneity needed to sustain cellular functions. The continued efforts create advanced cell mimics, namely, artificial cells, demands strategies for constructing similarly heterogeneous structures localized functionalities. Here, we introduce a platform membraneless from self-assembly of synthetic DNA nanostructures in which domains can be established thanks prescribed...
Biology has evolved a variety of agents capable permeabilizing and disrupting lipid membranes, from amyloid aggregates, to antimicrobial peptides, venom compounds. While often associated with disease or toxicity, these are also central many biosensing therapeutic technologies. Here, we introduce class synthetic, DNA-based particles membranes. The have finely programmable size, self-assemble all-DNA cholesterol-DNA nanostructures, the latter forming membrane-adhesive core former protective...
Thanks to its biocompatibility, versatility, and programmable interactions, DNA has been proposed as a building block for functional, stimuli-responsive frameworks with applications in biosensing, tissue engineering, drug delivery. Of particular importance vivo is the possibility of making such nanomaterials responsive physiological stimuli. Here, we demonstrate how combining noncanonical G-quadruplex (G4) structures amphiphilic constructs yields nanostructures, which termed "Quad-Stars",...
Many emerging technologies require materials with well-defined three-dimensional nanoscale architectures. Production of these structures is currently underpinned by self-assembling amphiphilic macromolecules or engineered all-DNA building blocks. Both approaches produce restricted ranges crystal geometries due to synthetic amphiphiles' simple shape and limited specificity, the technical difficulties in designing space-filling DNA motifs targeted shapes. We have overcome limitations...
Synthetic cells, like their biological counterparts, require internal compartments with distinct chemical and physical properties where different functionalities can be localized. Inspired by membrane-less compartmentalization in here, we demonstrate how microphase separation used to engineer heterogeneous cell-like architectures programmable morphology compartment-targeted activity. The synthetic cells self-assemble from amphiphilic DNA nanostructures, producing core-shell condensates due...
The reliable preparation of functional, ordered, nanostructured frameworks would be a game changer for many emerging technologies, from energy storage to nanomedicine. Underpinned by the excellent molecular recognition nucleic acids, along with their facile synthesis and breadth available functionalizations, DNA nanotechnology is widely acknowledged as prime route rational design materials. Yet, crystalline programmable structure functionality remains challenge. Here we demonstrate potential...
Templated synthesis of proteins containing non-natural amino acids (nnAAs) promises to expand the chemical space available biological therapeutics and materials, but existing technologies are still limiting. Addressing these limitations requires a deeper understanding mechanism protein how it is perturbed by nnAAs. Here we examine impact nnAAs on formation ribosome utilization central elongation substrate: ternary complex native, aminoacylated tRNA, thermally unstable factor, GTP. By...
The binding of imidazolium salts to cucurbit[8]uril, CB[8], triggers a stepwise self-assembly process with semiflexible polymer chains and crystalline nanostructures as early- late-stage species, respectively. In such process, which involves the crystallization host–guest complexes, guest plays critical role in directing toward desirable morphologies. These include platelet-like aggregates two-dimensional (2D) fibers, which, moreover, exhibit viscoelastic lyotropic properties. Our...
DNA nanostructures with programmable shape and interactions can be used as building blocks for the self-assembly of crystalline materials prescribed nanoscale features, holding a vast technological potential. Structural rigidity bond directionality have been recognised key design features motifs to sustain long-range order in 3D, but practical challenges associated prescribing building-block geometry sufficient accuracy limited variety available designs. We recently introduced novel platform...
Target-induced DNA strand displacement is an excellent candidate for developing analyte-responsive circuitry to be used in clinical diagnostics and synthetic biology. While most available technologies rely on free diffuse bulk, here we explore the use of liposomes as scaffolds DNA-based sensing nanodevices. Our proof-of-concept circuit responds presence a model target analyte by releasing strand, which turn activates fluorescent reporter. Through combination experiments coarse-grained Monte...
Three-dimensional crystalline frameworks with nanoscale periodicity are valuable for many emerging technologies, from nanophotonics to nanomedicine. DNA nanotechnology has emerged as a prime route constructing these materials, most approaches taking advantage of the structural rigidity and bond directionality programmable building blocks. Recently, we have introduced an alternative strategy reliant on flexible, amphiphilic junctions dubbed C-stars, whose ability crystallize is modulated by...
<div> <p>The reliable preparation of functional, ordered, nanostructured frameworks would be a game changer for many emerging technologies, from energy storage to nanomedicine. Underpinned by the excellent molecular recognition nucleic acids, along with their facile synthesis and breadth available functionalizations, DNA Nanotechnology is widely acknowledged as prime route rational design materials. Yet, crystalline programmable structure functionality remains challenge. Here we...
Abstract Biological cells display complex internal architectures, with distinct micro environments that establish the chemical heterogeneity needed to sustain cellular functions. The continued efforts create advanced cell mimics – artificial demands strategies construct similarly heterogeneous structures localized functionalities. Here, we introduce a platform for constructing membrane-less from self-assembly of synthetic DNA nanostructures, in which domains can be established thanks...
A study of the dwarf nova EM Cyg is presented, based on 562 photographic observations, 1949-54. The nova-like variation shows, from time to time, relatively stable light curves up 200-220 days as well considerable seasonal changes curve and period. mean cycle length may be around 24-25 days. An attempt has been made detect eclipsing in close binary system. Key words: photometry - novae binaries
The reliable preparation of functional, ordered, nanostructured frameworks would be a game changer for many emerging technologies, from energy storage to nanomedicine. Underpinned by the excellent molecular recognition nucleic acids, along with their facile synthesis and breadth available functionalizations, DNA Nanotechnology is widely acknowledged as prime route rational design materials. Yet, crystalline programmable structure functionality remains challenge. Here we demonstrate potential...
Thanks to its biocompatibility, versatility and programmable interactions, DNA has been proposed as a building block for functional, stimuli-responsive frameworks with applications in biosensing, tissue engineering drug delivery. Of particular importance vivo is the possibility of making such nano-materials responsive physiological stimuli. Here we demonstrate how combining noncanonical G-quadruplex (G4) structures amphiphilic constructs yields nanostructures, which termed "Quad-Stars",...