A5005246399- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- Global Trade and Competitiveness
- Ubiquitin and proteasome pathways
- Childhood Cancer Survivors' Quality of Life
- Peroxisome Proliferator-Activated Receptors
- Education and Cultural Studies
- Family Support in Illness
- Fungal Biology and Applications
- Glioma Diagnosis and Treatment
- Innovation and Knowledge Management
- International Business and FDI
- Phytochemistry and Bioactivity Studies
- T-cell and B-cell Immunology
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Polysaccharides and Plant Cell Walls
Bambino Gesù Children's Hospital
2023-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2025
Jagiellonian University
2020-2021
Oklahoma Medical Research Foundation
2021
John Paul II Catholic University of Lublin
2013
The combination of chemotherapeutic agents with immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment. However, its success is often limited by insufficient priming in certain tumors, including pediatric malignancies. In this report, we explore clinical trials currently investigating the use immunogenic cell death (ICD)-inducing chemotherapies ICIs for both adult and cancers. Given data available focused on recent preclinical studies evaluating efficacy these combinations...
Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) metabolizes peptides inside the ER and shapes peptide repertoire available for binding to Major Histocompatibility Complex Class I molecules (MHC-I). However, it may have additional effects on cellular homeostasis, which not been explored. To address these questions, we used both genetic silencing of ERAP1 expression as well treatment with a selective allosteric inhibitor probe changes in immunopeptidome proteome A375 melanoma cancer cell...
Abstract Background Checkpoint immunotherapy unleashes tumor control by T cells, but it is undermined in non-immunogenic tumors, e.g. with low MHC class I expression and neoantigen burden, such as neuroblastoma (NB). Endoplasmic reticulum aminopeptidase 1 (ERAP1) an enzyme that trims peptides before loading on molecules. Inhibition of ERAP1 results the generation new antigens able inducing potent anti-tumor immune responses. Here, we identify a novel non-toxic combinatorial strategy based...
Abnormal secretion of epidermal growth factor (EGF) by non-neuronal cells (e.g., glioma-associated microglia) establishes a feedback loop between glioblastoma multiforme (GBM) invasion and functional disruption brain tissue. Considering the postulated significance this vicious circle for GBM progression, we scrutinized mechanisms EGF-dependent pro-invasive signaling in terms its interrelations with energy metabolism reactive oxygen species (ROS) production. The effects EGF on invasiveness...
ABSTRACT Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) metabolizes peptides inside the ER and shapes peptide repertoire available for binding to Major Histocompatibility Complex Class I molecules (MHC-I). Moreover, it may have additional effects on cellular homeostasis, which not been explored. To address these questions, we used both genetic silencing of ERAP1 expression as well treatment with a selective allosteric inhibitor probe changes in immunopeptidome proteome A375 melanoma...
Abstract Innate-like T cells, including invariant NKT mucosal-associated (MAIT) and γ δ (γδT) are groups of unconventional lymphocytes. They play important roles in the immune system. Because lack Cre recombinase lines that specific for innate-like pan–T cell often used to study cells. In this study, we found distal Lck promoter–driven (dLckCre) which gene promoter drives expression late stage thymocyte development has limited function cells using ROSA26floxed-Stop-tdTomato reporter....
Stomach cancer is the 4th most common diagnosed worldwide. Despite intensive research on its etiopathology, treatment strategies have not changed in last 50 years. Mushrooms recently attracted much attention as source of bioactive compounds that can potentially complement therapies. Here, we extracted a phenolic fraction from Lactarius deterrimus and analyzed composition bioactivity against gastric (AGS) cells. The complexity L. was revealed by an HPLC assay, accompanied cytostatic,...