- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Particle Detector Development and Performance
- Dark Matter and Cosmic Phenomena
- Cosmology and Gravitation Theories
- Computational Physics and Python Applications
- Neutrino Physics Research
- Radiation Detection and Scintillator Technologies
- Astrophysics and Cosmic Phenomena
- Black Holes and Theoretical Physics
- Medical Imaging Techniques and Applications
- Muon and positron interactions and applications
- Particle Accelerators and Free-Electron Lasers
- Distributed and Parallel Computing Systems
- Nuclear Physics and Applications
- Antimicrobial Peptides and Activities
- Nuclear reactor physics and engineering
- Monoclonal and Polyclonal Antibodies Research
- Radiation Therapy and Dosimetry
- Advanced Data Storage Technologies
- Gamma-ray bursts and supernovae
- Biochemical and Structural Characterization
- Atomic and Subatomic Physics Research
- Glycosylation and Glycoproteins Research
Sofia University "St. Kliment Ohridski"
2016-2025
Institute of High Energy Physics
2012-2024
Bulgarian Academy of Sciences
1994-2024
University of Antwerp
2024
A. Alikhanyan National Laboratory
2022-2024
Beihang University
2023
Institute of High Energy Physics
2019-2021
National Center for Supercomputing Applications
2012-2020
Peking University
2020
Center for Migration Studies of New York
2020
Our objective is to reveal the molecular mechanism of anti-inflammatory action low-molecular-weight heparin (LMWH) based on its influence activity two key cytokines, IFNγ and IL-6. The binding IL-6 resulting inhibition their were studied by means extensive molecular-dynamics simulations. effect LMWH signalling inside stimulated WISH cells was investigated measuring antiproliferative translocation phosphorylated STAT1 in nucleus. We found that binds with high affinity able fully inhibit...
In view of the High Luminosity upgrade CERN LHC, forward CMS Muon spectrometer will be extended with two new stations improved Resistive Plate Chambers (iRPC) covering pseudorapidity range from 1.8 to 2.4. Compared present RPC system, gap thickness is reduced lower avalanche charge, and an innovative 2D strip readout geometry proposed. These improvements allow iRPC detector cope higher background rates. A Front-End-Board (FEB) designed signals a threshold as low 30 fC integrated Time Digital...
ORF6 is responsible for suppressing the immune response of cells infected by SARS-CoV-2 virus. It also most toxic protein SARS-CoV-2, and its actions are associated with viral pathogenicity. Here, we study in silico vitro structure protein, interaction RAE1 mechanism action behind high toxicity. We show both computationally experimentally that ORF6, embedded cytoplasmic membranes, binds to sequesters it cytoplasm, thus depleting availability nucleus impairing nucleocytoplasmic mRNA...
Human interferon γ (hIFNγ) is a crucial immunomodulatory cytokine that exerts its effects by binding to high-affinity receptor complex on the cell surface. In addition binding, hIFNγ also displays strong affinity for heparin and heparan sulphate, primarily via C-terminal domain. This interaction influences various physicochemical properties of cytokine, including affinity, could be harnessed designing inhibitors. Current experimental methods cannot precisely determine sulphate group...
Machine learning methods are being introduced at all stages of data reconstruction and analysis in various high-energy physics experiments. We present the development application convolutional neural networks with modified autoencoder architecture for pulse arrival time amplitude individual scintillating crystals electromagnetic calorimeters other detectors. The network performance is discussed as well xAI further investigation algorithm improvement output accuracy.
The SARS-CoV-2 spike receptor-binding motif is crucial for viral entry via interaction with the human ACE2 receptor. Mutations N501Y and E484K, found in several variants of concern, impact transmissibility immune escape, but experimental data on their binding effects remain inconsistent. Using isothermal titration calorimetry (ITC) molecular dynamics (MD) simulations, we analyzed thermodynamic structural these mutations. ITC confirmed that increases affinity by 2.2-fold, while E484K enhances...