A5080473297- Visual perception and processing mechanisms
- Ophthalmology and Eye Disorders
- Neural dynamics and brain function
- Glaucoma and retinal disorders
- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Ophthalmology and Visual Impairment Studies
- Vestibular and auditory disorders
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Olfactory and Sensory Function Studies
- Medical and Biological Sciences
- Neuroinflammation and Neurodegeneration Mechanisms
- Connexins and lens biology
- Advanced Neuroimaging Techniques and Applications
- Neurological Disorders and Treatments
- Biochemical effects in animals
- Axon Guidance and Neuronal Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- ATP Synthase and ATPases Research
- Origins and Evolution of Life
- Migraine and Headache Studies
- Neural Networks and Applications
- Gaze Tracking and Assistive Technology
- Aortic aneurysm repair treatments
Centre Interdisciplinaire de Recherche en Biologie
2014-2021
Inserm
2014-2021
Collège de France
2007-2021
Université Paris Sciences et Lettres
2018-2021
Centre National de la Recherche Scientifique
1994-2021
Sorbonne Université
1984-2014
Laboratoire Psychologie de la Perception
2005-2013
Délégation Paris 6
2005
Institut de Psychiatrie et Neurosciences de Paris
1992
University of Edinburgh
1989
How astrocytes close a critical period During the visual period, brain circuits are rewired to adjust sensory input. Closure of stabilizes circuits. Looking at development in mouse cortex, Ribot et al. found that increase their expression gap junction channel subunit connexin 30, which turn inhibits matrix-degrading enzyme (see Perspective by Kofuji and Araque). As matrix stabilizes, inhibitory interneurons mature, unusual flexibility comes an end. Science , abf5273, this issue p. 77 ; see...
Strabismus is a frequent ocular disorder that develops early in life humans. As general rule, it characterized by misalignment of the visual axes which most often appears during critical period development. However other characteristics strabismus may vary greatly among subjects, for example, being convergent or divergent, horizontal vertical, with variable angles deviation. Binocular vision also greatly. Our main goal here to develop idea such "polymorphy" reflects wide variety possible...
Abstract Seventeen callosally projecting axons originating near the border between areas 17 and 18 in adult cats were anterogradely labelled with biocytin reconstructed 3‐D from serial sections. All terminated contralateral 17/18 border. However, they differed their diameter, tangential radial distributions, overall geometry of terminal arbors. Diameters ranged 0.45 2.25 μm. Most multiple columns scattered over several square millimetres cortex. Thus general callosal connections are not...
The functional specificity of callosal connections was investigated in visual areas 17 and 18 adult cats, by combining vivo optical imaging intrinsic signals with labeling axons. Local injections neuronal tracers were performed one hemisphere eight single axons reconstructed the opposite hemisphere. distributions injection sites axon terminals analyzed respect to maps both hemispheres. Typically, each displayed 2 or 3 clusters synaptic boutons layer II/III upper part IV. These preferentially...
It remains controversial whether and how spatial frequency (SF) is represented tangentially in cat visual cortex. Several models were proposed, but there no consensus. Worse still, some data indicate that the SF organization previously revealed by optical imaging techniques simply reflects non-stimulus-specific responses. Instead, stimulus-specific responses arise from homogeneous distribution of geniculo-cortical afferents representing X Y pathways. To clarify this, we developed a new...
Object orientations in the visual field are columned into specific orientation domains primary cortex [area 17 (A17) and area 18 (A18)] of cats. At single-cell level, adapting A17 neurons to a non-preferred (adaptor) shifts their preferred either towards adaptor (attractive shift) or away from it (repulsive shift). As A18 reciprocally connected, we sought determine how changes correlated with recorded anesthetised To this end, simultaneously traced populations A18, using intrinsic optical...
Aim: In humans, images in the median plane of head either fall on both nasal hemi-retinas or temporal hemi-retinas. Interhemispheric connections allow cortical cells to have receptive fields opposite sides. The major interhemispheric connection, corpus callosum, is implicated central stereopsis and disparity detection front fixation plane. Yet individuals with agenesis callosum may show normal vergence. We set out study a possible connection between primary visual areas via anterior...
In the mammalian primary visual cortex, corpus callosum contributes to unification of hemifields that project two hemispheres. Its development depends on experience. When this is abnormal, callosal connections must undergo dramatic anatomical and physiological changes. However, data concerning these changes are sparse incomplete. Thus, little known about impact abnormal postnatal experience their role in unifying representation hemifields. Here, effects early unilateral convergent strabismus...
Abstract The aim of this study was to investigate the development visual callosal transfer in normally reared cat. Two‐ nine‐week‐old kittens and adults (used as controls) underwent section optic chiasm. Three days later, animals were placed under anaesthesia paralysed; unit activities recorded from cortical areas 17 18 white matter one hemisphere. units tested for their responses stimulation each eye successively. Out 1036 neurons, 185 could be activated through contralateral explored...
Commissural connections between primary visual cortical maps of the two hemispheres are essential to unify split representation field. In normal adult cats, callosal essentially restricted border areas A17 and A18, where central vertical meridian is projected. contrast, early convergent strabismus leads an expanded callosal-receiving zone, as repeatedly indicated by anatomical experiments. We investigated here functional correlates this widespread distribution terminals analysing...
Infantile strabismus impairs the perception of all attributes visual scene. High spatial frequency components are no longer visible, leading to amblyopia. Binocularity is altered, loss stereopsis. Spatial impaired as well detection vertical orientation, fastest movements, directions movement, highest contrasts and colors. also affects other vision-dependent processes such control postural stability. But presently, rehabilitative therapies for infantile by ophthalmologists, orthoptists...