Abstract In situ vaccination (ISV) triggers antitumor immune responses using the patient’s own cancer antigens, yet limited neoantigen release hampers its efficacy. Our novel combination therapy involves low-dose local cisplatin followed by ISV with a TLR7/8/9 agonist formulation (CR108), in which CR108 boosts and sustains induced cisplatin-released neoantigens. mouse models, cisplatin+CR108 significantly outperformed or alone abrogating established 4T1 B16 tumors. The synergistic effects of...

Gastrointestinal bleeding (GIB) is associated with high mortality rates among critically ill patients. The hemoglobin-to-red blood cell distribution width ratio (HRR) has recently emerged as a potential prognostic marker in various clinical settings. However, the association between HRR and prognosis patients GIB unclear. We conducted retrospective cohort study using MIMIC-IV database (version 2.2). Patients diagnosed were included based on predefined criteria. was calculated of hemoglobin...

With the increasing severity of global climate change, environmental issues have become a key factor constraining sustainable economic development. Environmental, social, and corporate governance (ESG) is in line with concept enterprises’ development, it significant to study mechanism ESG disclosure on carbon performance for low-carbon transformation enterprises. Based panel data Chinese heavily polluting companies, two-way fixed-effects model used analyze relationship theoretically validate...

Carbon control has become a key strategy in the high-quality development (HQD) phase of emerging countries, but spillover effects implementing carbon instruments on HQD remain to be verified. In order explore realistic level China and mechanism how controls impact it, this paper analyzes regional differences spatio-temporal dynamics by using Chinese provincial panel data from 2006 2019. This study evaluated implications regionally implemented emissions trading scheme (ETS)...

ABSTRACT Background Respiratory syncytial virus (RSV) is an important cause of disease in older adults. Vaccines against RSV infections and respiratory diseases are large market demand. Although there currently two licensed RSV-based pre-F antigen vaccines available for adults, no G antigen-based vaccine authorized. This phase 2 study aimed to evaluate the safety immunogenicity a recombinant protein-based this population. Methods A phase-2 randomized, double-blind, placebo-controlled,...

Abstract The involved object of systematic innovation and management is neither a single goal nor meth-od. Firstly, the research organic whole composed multiple node elements with certain degree correlation. Secondly, method multi-dimensional, comprehensive, all round highly efficient. Innovation should break through existing thinking framework, change structure, add new components, give energy produce functions. 5W1H questioning approach problem-solving that answers basic within problem...

Blackbody emission such as the from incandescent sources usually possesses a broadband spectrum covering whole infrared wavelength range. Most of energy goes into unwanted range and consequently causes low efficiency. Recently, metasurfaces with two-dimensional subwavelength artificial nanostructures have been widely studied due to their flexibility in modulating optical properties, thus providing an ideal platform for controlling thermal emission. The use synthetic dimension methods has...

Abstract With the continuous expansion and change of tourism market, massive amount, complexity dynamic data make establishment management decision support system has become an important issue in industry. In this paper, we use plain Bayesian classification algorithm, improved Apriori association gray GM(1, N) prediction model to mine process big combine 3S technology Agent-based knowledge representation realize construction based on analysis, optimal for planning tourist attractions routes....

Abstract The paper proposes the concept of land use system that is considered as a whole interaction among three main bodies government, enterprises and residents, nature. With help structural equation model, based on SPSS AMOS software, according to path coefficients latent variables observed in determines impact process 20 influencing factors at Heilongjiang Province enterprise resident level economic, environmental social performance urban system. results show are importance degree...

Based on the research results of scholars from domestic and overseas, we construct a evaluation index system for post- oilfield ground engineering project focusing characteristics engineer combining development oilfield. The includes 3 primary indicators, such as pre-project, 8 secondary indicators 35 tertiary indicators. Multistage fuzzy with combination quantitative analysis qualitative degree success method are used Post-evaluation which may lead to reference decision-making investment...

Reputation is the foundation stone of market economy. Regional reputation a component social reputation, and it needs perfect system to support, an important constructing choose scientific evaluation index method. This paper sets up regional first, then evaluates with fuzzy comprehensive evaluation, uses improved AHP confirm weights.

Reputation is an important intangible asset, while reputation assessment makes a significant function in the process of choosing corporate collaborators. With technology improvements internet, management built by Supply and Demand Network has become reality. In this work system was developed through qualification reputation. Validation reliability had been done. Moreover, extended model taking frequency, amount timeliness transaction. At last, paper chart for collaborator selection using...

Port promotes economy to grow rapidly, but causes certain damage ecological environment. For the sustainable development of port, construction green port is a very wise choice. Taking Shanghai as an example, this paper discusses based on evaluation index system Analytic Hierarchy Process and fuzzy comprehensive method, puts forward corresponding suggestions, in order provide reference value for better faster Shanghai. Firstly, introduces background topic significance research, including...

This paper takes the manufacturing industry in three northeastern provinces as research object. It establishes an index system based on connotation of high-quality development from six aspects: efficiency, green development, innovation-driven, quality brand, people's livelihood sharing, and openness, measures it used entropy-weight-TOPSIS method. The results show that, whole, Northeast China has been steadily improving, there are differences level among China, showing that Liaoning is...

The Degree of Polymerization (DP) oil-paper insulation decreases gradually during thermal ageing, determining its remaining service life. Previous studies have found that under certain aging conditions, there is a lower limit value for DP called Levelling-off (LODP), which significantly impacts the life insulation. Although many used second-order kinetic models cellulose degradation to describe changes in with time, needs be more research on factors affecting LODP. This article analyzes...

Based on the network economy innovation of enterprise organization is a kind activity which regards IT application as foundation, integrates resources and shares information principle, authorizes work team emphasizes humanized management guide, quickly responds to changing market demand goal. This paper, by anglicizing drawbacks traditional hierarchies mode development trend organization, discusses learning business process reengineering virtual organizations make contributions based...

Based on traders’ goods, service,the way of transaction and time, the paper establishes B2B reputation evaluation index system, applies Analytic Hierarchy Process to give weight. Using model, takes into account evaluators’ own reputation, amount, time other factors, dynamically adjusting value generating traders which is as basis for choose trading partners, promote development e-commerce. Key words: B2B; Traders; Enterprises reputation; Evaluation

With the development of social economy, emission greenhouse gases and environmental pollution has causes effect problems that need to be urgently solved Combining with definition connotation low carbon economy development, on basis analyzing production petroleum gas resources current consumption at home abroad, this paper discusses low-carbon path enterprises.

In China, as heavily polluting enterprises, oil and gas while playing a major role in national economy the people's livelihood, should assume environmental responsibility of state-owned enterprises. Through in-depth corporate research, influencing factors motive enterprises are explored. Principal component analysis method was used to reduce dimensionality factors, extract four main factors. Then relationship between each factor implementation so various analysed depth, causality diagram...