A5012644925- RNA modifications and cancer
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- Reproductive biology and impacts on aquatic species
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Aquaculture Nutrition and Growth
- Nanoparticle-Based Drug Delivery
- Diet, Metabolism, and Disease
- Biochemical and Molecular Research
- Drug Transport and Resistance Mechanisms
- Marine Biology and Environmental Chemistry
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
University of Campania "Luigi Vanvitelli"
2020-2023
Colorectal cancer (CRC) is the second deadliest worldwide despite significant advances in both diagnosis and therapy. The high incidence of CRC its poor prognosis, partially attributed to multi-drug resistance antiapoptotic activity cells, arouse strong interest identification development new treatments. S-Adenosylmethionine (AdoMet), a natural compound nutritional supplement, well known for antiproliferative proapoptotic effects as potential overcoming drug many kinds human tumors. Here, we...
In order to study novel therapeutic approaches taking advantage of natural compounds showing anticancer and anti-proliferative effects, we focused our interest on S-adenosyl-l-methionine, a naturally occurring sulfur-containing nucleoside synthesized from adenosine triphosphate methionine by adenosyltransferase, its potential in overcoming drug resistance colon cancer cells devoid p53.In the present study, demonstrated that S-adenosyl-l-methionine overcomes uL3-mediated p53 deleted cells....
There has been an intense focus to uncover the molecular mechanisms by which fasting triggers adaptive cellular responses in major organs of body. Here, we show that mice, hepatic S-adenosylmethionine (SAMe)-the principal methyl donor-acts as a metabolic sensor nutrition fine-tune catabolic-fasting response modulating phosphatidylethanolamine N-methyltransferase (PEMT) activity, endoplasmic reticulum-mitochondria contacts, β-oxidation, and ATP production liver, together with FGF21-mediated...
(1) Purpose: The methyl donor S-Adenosylmethionine (AdoMet) has been widely explored as a therapeutic compound, and its application-alone or in combination with other molecules-is emerging potential effective strategy for the treatment chemoprevention of tumours. In this study, we investigated antitumor activity AdoMet Laryngeal Squamous Cell Carcinoma (LSCC), exploring underlying mechanisms. (2) Results: We demonstrated that induced ROS generation triggered autophagy consistent increase...
Metastasis is a leading cause of mortality and poor prognosis in colorectal cancer (CRC). Thus, the identification new compounds targeting cell migration represents major clinical challenge. Recent findings evidenced central role for dysregulated Notch CRC correlation between overexpression tumor metastasis. MicroRNAs (miRNAs) have been reported to cross-talk with its regulation. Therefore, restoring underexpressed miRNAs could represent an encouraging therapeutic approach against CRC. In...
The aim of this paper is to assess, by real-time polymerase chain reaction and in situ hybridization, the expression estrogen receptors ER1 ER2 during ovarian cycle Mytilus galloprovincialis. By considering four phases reproductive cycle, that stasis previtellogenic stage (Stage 0), early vitellogenesis I), II), full-grown oocyte III), our investigation demonstrates two are differently expressed investigated cycle: reaches highest level at Stage III, whereas II, with always present higher...