A5048158896- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- Early Childhood Education and Development
- Advanced Neuroimaging Techniques and Applications
- Child Abuse and Trauma
- Mental Health Research Topics
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
- Neural and Behavioral Psychology Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroendocrine regulation and behavior
- Psychological Well-being and Life Satisfaction
- Advanced MRI Techniques and Applications
- Cognitive Abilities and Testing
- Health disparities and outcomes
- Neonatal and fetal brain pathology
- Cutaneous lymphoproliferative disorders research
- Heart Rate Variability and Autonomic Control
- Maternal Mental Health During Pregnancy and Postpartum
- Nail Diseases and Treatments
- Cutaneous Melanoma Detection and Management
- Topological and Geometric Data Analysis
- Global Health Care Issues
- Nonmelanoma Skin Cancer Studies
University of Pittsburgh
2017-2025
Saint Louis University
2023
Allen Institute for Brain Science
2023
Icahn School of Medicine at Mount Sinai
2023
UCLouvain Saint-Louis Brussels
2022
Florida International University
2021
University of California, Berkeley
2021
Temple University
2021
Technical University of Darmstadt
2021
Center for the Neural Basis of Cognition
2019-2021
Children living in poverty generally perform poorly school, with markedly lower standardized test scores and educational attainment. The longer children live poverty, the greater their academic deficits. These patterns persist to adulthood, contributing lifetime-reduced occupational
Individuals who experience early adversity, such as child maltreatment, are at heightened risk for a broad array of social and health difficulties. However, little is known about how this behavioral instantiated in the brain. Here we examine neurobiological contribution to individual differences human behavior using methodology appropriate use with pediatric populations paired an in-depth measure behavior. We show that alterations orbitofrontal cortex among individuals experienced physical...
Living in poverty places children at very high risk for problems across a variety of domains, including schooling, behavioral regulation, and health. Aspects cognitive functioning, such as information processing, may underlie these kinds problems. How might affect the brain functions underlying processes? Here, we address this question by observing analyzing repeated measures development young between five months four years age from economically diverse backgrounds (n = 77). In doing so,...
Facets of the post-natal environment including type and complexity environmental stimuli, quality parenting behaviors, amount stress experienced by a child affects brain behavioral functioning. Poverty is pervasive experience that likely to influence biobehavioral processes because children developing in such environments often encounter high levels reduced stimulation. This study explores association between socioeconomic status hippocampus, region involved learning memory known be affected...
Cognitive deficits have been reported in children who experienced early neglect, especially raised institutionalized settings. Previous research suggests that neglect may differentially affect the directional organization of white matter prefrontal cortex (PFC). This be one mechanism to explain cognitive associated with neglect. To test this idea, properties and neurocognitive performance were assessed suffered those typical environments (n = 63, Mage 11.75 years). As predicted,...
Prior research demonstrates a link between exposure to childhood adversity and psychopathology later in development.However, work on mechanisms linking fails account for specificity these pathways across different types of adversity.Here, we test conceptual model that distinguishes deprivation threat as distinct forms with psychopathology.Deprivation involves an absence inputs from the environment, such cognitive social stimulation, influence by altering development, verbal abilities.Threat...
Neuroscience is advancing standardization and tool development to support rigor transparency. Consequently, data pipeline complexity has increased, hindering FAIR (findable, accessible, interoperable reusable) access. brainlife.io was developed democratize neuroimaging research. The platform provides standardization, management, visualization processing automatically tracks the provenance history of thousands objects. Here, described evaluated for validity, reliability, reproducibility,...
A large corpus of research indicates that exposure to stress impairs cognitive abilities, specifically executive functioning dependent on the prefrontal cortex (PFC). We collected structural MRI scans (<i>n</i> = 61), well-validated assessments functioning, and detailed interviews assessing in humans examine whether cumulative life affected brain morphometry one type spatial working memory, during adolescence—a critical time development reorganization. Analysis variations structure revealed...
Early life stress (ELS) is strongly associated with negative outcomes in adulthood, including reduced motivation and increased mood. The mechanisms mediating these relations, however, are poorly understood. We examined the relation between exposure to ELS reward-related brain activity, which known predict mood, at age 26, a sample followed since kindergarten annual assessments. Using functional neuroimaging, we assayed individual differences activity of ventral striatum (VS) during...
The experience of early life stress is a consistently identified risk factor for the development mood and anxiety disorders. Preclinical research employing animal models has made inroads in understanding this association suggests that negative sequelae may be mediated by developmental disruption corticolimbic structures supporting responsiveness. Work humans corroborated idea, as childhood adversity been associated with alterations gray matter volumes hippocampus, amygdala, medial prefrontal...
Children who experience early adversity often develop emotion regulatory problems, but little is known about the mechanisms that mediate this relation. We tested whether general associative learning processes contribute to associations between adversity, in form of child maltreatment, and negative behavioral outcomes.Eighty-one participants 12 17 years age were recruited for study completed a probabilistic Task. Forty-one these had been exposed physical abuse, adversity. Forty additional...
The experience of child maltreatment is a significant risk factor for the development later internalizing disorders such as depression and anxiety. This particularly heightened after exposure to additional, more contemporaneous stress. While behavioral evidence exists "stress sensitization," little known about mechanisms mediating relationships, within brain. Here we report that independent recent life stress, gender, age associated with reduced structural integrity uncinate fasciculus,...
Abstract Children who experience severe early life stress show persistent deficits in many aspects of cognitive and social adaptation. Early might be associated with these broad changes functioning because it impairs general learning mechanisms. To explore this possibility, we examined whether individuals experienced abusive caregiving childhood had difficulties instrumental and/or flexibility as adolescents. Fifty‐three 14–17‐year‐old adolescents (31 exposed to high levels stress, 22...
Abstract Subject motion can introduce noise into neuroimaging data and result in biased estimations of brain structure. In-scanner compromise quality a number ways varies widely across developmental clinical populations. However, quantification structural image is often limited to proxy or indirect measures gathered from functional scans; this may be missing true differences related these potential artifacts. In study, we take advantage novel informatic tools, the CAT12 toolbox, more...
Sparse systems are usually parameterized by a tuning parameter that determines the sparsity of system. How to choose right is fundamental and difficult problem in learning sparse In this paper, treating as an additional dimension, persistent homological structures over space introduced explored. The then further exploited speeding up computation using proposed soft-thresholding technique. topological used multivariate features tensor-based morphometry (TBM) characterizing white matter...
Background The experience of childhood maltreatment is a significant risk factor for the development depression. This particularly heightened after exposure to additional, more contemporaneous stress. While behavioral evidence exists this relation, little known about biological correlates these stress interactions. Identifying such may provide biomarkers later Methods Here, we leverage behavioral, experiential, and neuroimaging data from Duke Neurogenetics Study identify potential exposure....
Abstract On-going, large-scale neuroimaging initiatives can aid in uncovering neurobiological causes and correlates of poor mental health, disease pathology, many other important conditions. As projects grow scale with hundreds, even thousands, individual participants scans collected, quantification brain structures by automated algorithms is becoming the only truly tractable approach. Here, we assessed spatial numerical reliability for newly deployed segmentation hippocampal subfields...