A5062204015- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- DNA and Nucleic Acid Chemistry
- Immune Cell Function and Interaction
- Luminescence and Fluorescent Materials
- Seaweed-derived Bioactive Compounds
- Surfactants and Colloidal Systems
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Molecular Sensors and Ion Detection
- Nanoparticle-Based Drug Delivery
- Luminescence Properties of Advanced Materials
- Ubiquitin and proteasome pathways
- Echinoderm biology and ecology
- Graphene and Nanomaterials Applications
- Carbon Nanotubes in Composites
- Supramolecular Self-Assembly in Materials
- Advanced Polymer Synthesis and Characterization
- Carbon and Quantum Dots Applications
- Electrospun Nanofibers in Biomedical Applications
- Ammonia Synthesis and Nitrogen Reduction
- Immune cells in cancer
- Photoacoustic and Ultrasonic Imaging
Pukyong National University
2016-2025
Kongju National University
2023
Marine Biodiversity Institute of Korea
2022-2023
DWI – Leibniz Institute for Interactive Materials
2020-2021
Government of the Republic of Korea
2020
University of Groningen
2010-2017
Dana-Farber Cancer Institute
2012
Bioengineering Center
2010-2012
Max Planck Institute for Polymer Research
2010
University of Twente
2010
Most previously reported methods for purifying DNA-origami nanostructures rely on agarose-gel electrophoresis (AGE) separation. Although AGE is routinely used to yield 0.1–1 µg purified DNA nanostructures, obtaining >100 of structure through typically laborious because the post-electrophoresis extraction, desalting and concentration steps. Here, we present a readily scalable purification approach utilizing rate-zonal centrifugation, which provides comparable separation resolution as AGE. The...
DNA amphiphile particles template formation of virus capsids and enable their loading.
Efficient cancer therapy is sought not only for primary tumor treatment but also the prevention of metastatic growth. Immunotherapy has been shown to prevent metastasis by inducing antigen-specific immune responses. Indocyanine green (ICG) a peak spectral absorption at about 800 nm, which makes it photothermal reagent direct solid tumors (PTT). Since PTT alone cannot fully induce response metastasis, combination and immunotherapy developed as new strategy treatment.Thermal responsive...
Abstract Induction of antigen-specific immune activation by the maturation dendritic cells (DCs) is a strategy used for cancer immunotherapy. In this study, we find that FimH, which an Escherichia coli adhesion portion, induces toll-like receptor 4-dependent and myeloid differentiation protein 2-independent DC in mice vivo. A combined treatment regimen with FimH antigen promotes activation, including proliferation T cells, production IFN-γ TNF-α, infiltration effector into tumors,...
In advanced cancer therapy, the combinational therapeutic effect of photothermal therapy (PTT) using near-infrared (NIR) light-responsive nanoparticles (NPs) and anti-cancer drug delivery-mediated chemotherapy has been widely applied. present study, a facile, low-cost, solution-based method, we developed synthesized fucoidan, natural polymer isolated from seaweed that demonstrated effect, coated NPs with it as an ideal candidate in chemo-photothermal against cells. Fucoidan-coated copper...
DNA block copolymer doing it all: A potentially scalable self-assembly method for single-walled carbon nanotubes (SWNTs) involves the use of amphiphilic copolymers. One such hybrid is able to cover entire area solution-based SWNT technologies, from selective dispersion nondestructive functionalization high-yield device fabrication as field-effect transistors (see picture; S: source, G: gate, D: drain electrode).
Rehmannia glutinosa polysaccharide (RGP) has shown an activation of immune cells in vitro. However, the stimulatory effect RGP a mouse vivo is not well studied. In this study, we examined on dendritic cell (DC) and anticancer immunity vivo. Treatments C56BL/6 mice induced increased levels co-stimulatory molecule expression pro-inflammatory cytokine production spleen DCs dependent toll-like receptor 4 (TLR4), those promoted interferon-gamma (IFNγ) CD4+ CD8+ T cells. also enhanced ovalbumin...
Abstract This work describes the synthesis and characterization of a new family DNA amphiphiles containing modified nucleobases. The hydrophobicity was imparted by introduction dodec‐1‐yne chain at 5‐position uracil base, which allowed precise simple tuning hydrophobic properties through solid‐phase synthesis. micelles formed from these sequences were characterized atomic force microscopy, dynamic light scattering, polyacrylamide gel electrophoresis. These experiments revealed role quantity...
Eine potenziell skalierbare Methode der Selbstorganisation von einwandigen Kohlenstoff-Nanoröhren (SWNTs) nutzt amphiphile DANN-Blockcopolymere. Ein solches Hybrid ist dazu in Lage, die gesamte Bandbreite lösungsbasierter SWNT-Technologien abzudecken, selektiver Dispergierung über zerstörungsfreie Funktionalisierung bis zur Herstellung z. B. Feldeffekttransistoren (siehe Bild, S: Source-, G: Gate-, D: Drain-Elektrode). Detailed facts of importance to specialist readers are published as...
Functional interfaces of biomolecules and inorganic substrates like semiconductor materials are utmost importance for the development highly sensitive biosensors microarray technology. However, there is still a lot room improving techniques immobilization biomolecules, in particular nucleic acids proteins. Conventional anchoring strategies rely on attaching biomacromolecules via complementary functional groups, appropriate bifunctional linker molecules, or non-covalent electrostatic...