A5082117683- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Seaweed-derived Bioactive Compounds
- Echinoderm biology and ecology
- Immune Cell Function and Interaction
- Bioactive Compounds and Antitumor Agents
- Skin Protection and Aging
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- melanin and skin pigmentation
- Macrophage Migration Inhibitory Factor
- Photodynamic Therapy Research Studies
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Food Quality and Safety Studies
- Phytoestrogen effects and research
- RNA Interference and Gene Delivery
- Neurofibromatosis and Schwannoma Cases
- Nanoparticle-Based Drug Delivery
- Cancer, Stress, Anesthesia, and Immune Response
- Supramolecular Self-Assembly in Materials
- Urban Stormwater Management Solutions
- Microbial bioremediation and biosurfactants
- Advanced biosensing and bioanalysis techniques
- Cancer Research and Treatments
Pukyong National University
2019-2025
Ajou University
2025
Yeungnam University
2012-2022
Shanghai Public Health Clinical Center
2020-2022
Fudan University
2022
Korea Research Institute of Chemical Technology
2020-2021
Himchan Hospital
2021
Korea National University of Transportation
2019
Sungkyunkwan University
2013-2018
Samsung Medical Center
2016-2018
Most cancer-related deaths are due to metastasis or recurrence. Therefore, the ultimate goal of cancer therapy will be treat metastatic and recurrent cancers. Combination for one trial effective treating In this study, Escherichia coli-mimetic nanomaterials synthesized using coli membrane proteins, adhesion gold nanorods, which named E. mimetic AuNRs (ECA), combination against its ECA treatment with 808 nm laser irradiation eliminates CT-26 4T1 tumors via a photothermal effect. induces...
Abstract Induction of antigen-specific immune activation by the maturation dendritic cells (DCs) is a strategy used for cancer immunotherapy. In this study, we find that FimH, which an Escherichia coli adhesion portion, induces toll-like receptor 4-dependent and myeloid differentiation protein 2-independent DC in mice vivo. A combined treatment regimen with FimH antigen promotes activation, including proliferation T cells, production IFN-γ TNF-α, infiltration effector into tumors,...
Recent advances in supramolecular chemistry research have led to the development of artificial chemical systems that can form self-assembled structures imitate proteins involved regulation cellular function. However, intracellular polymerization operate inside living cells been seldom reported. In this study, we developed an intramitochondrial polymerization-induced self-assembly system for regulating fate cancer cells. It showed polymeric disulfide formation occurred due high reactive...
Waste-cooking oil (WCO) is defined as vegetable that has been used to fry food at high temperatures. The annual global generation of WCO 41–67 million tons. Without proper treatment, most abandoned in sinks and the solid residue disposed landfills, resulting serious environmental problems. Recycling valorizing have received considerable attention reduce its negative impact on ecosystems. To convert into a value-added compound, we aimed produce sophorolipids (SLs) are industrially important...
Immunotherapies have been gaining attention for the prevention of cancer recurrence and metastasis. Cancer immunotherapy can induce memory cells to target cancer-specific antigens and, thus, selectively kill cells. However, there are difficulties in inducing antigen-specific immunity due limited knowledge regarding antigens. In this study, we synthesized a dual-functional hydrogel antigen generation immune activation.To elicit self-antigen-specific response, an alginate-collagen-based...
Natural polysaccharides exhibit beneficial immune modulatory effects, including stimulatory and anti-cancer activities. In this study, we examined the effect of Codium fragile polysaccharide (CFP) on natural killer (NK) cell activation, its tumor-bearing mice. Intravenous CFP treatment C57BL/6 mice resulted in upregulation CD69, which is a marker associated with NK activation. addition, intracellular levels interferon (IFN)-γ cytotoxic mediators perforin granzyme B were markedly increased...
Natural polysaccharides have shown immune modulatory effects with low toxicity in both animal and human models. A previous study has that the polysaccharide from Codium fragile (CFP) promotes natural killer (NK) cell activation mice. Since NK is mediated by dendritic cells (DCs), we examined effect of CFP on DC evaluated subsequent induction anti-cancer immunity a murine model. Treatment induced bone marrow-derived (BMDCs). Moreover, subcutaneous injection promoted spleen lymph node DCs...
Although fucoidan, a well-studied seaweed-extracted polysaccharide, has shown immune stimulatory effects that elicit anticancer immunity, mucosal adjuvant via intranasal administration have not been studied. In this study, the effect of Ecklonia cava-extracted fucoidan (ECF) on induction anti-cancer immunity in lung was examined by administration. C57BL/6 and BALB/c mice, ECF promoted activation dendritic cells (DCs), natural killer (NK) cells, T mediastinal lymph node (mLN). The ECF-induced...
In this study, we tested whether biodiesel could be used as a feedstock for the microbial synthesis of sophorolipid, high value-added chemical. Sophorolipid was successfully produced from Starmerrella bombicola using hydrophobic substrate. Fed-batch fermentation carried out high-level production. Compared to flask culture, sophorolipid production concentration significantly increased 58.1 g/L 224.2 (an approximate increase 386%) fed-batch fermentation, which is highest value ever reported...
Melanoma is the most lethal form of skin cancer because it spreads easily to other tissues, thereby decreasing efficiency its treatment via chemo-, radio-, and surgical therapies. We suggest application an attachable hydrogel for melanoma whereby size amount incorporated indocyanine green (ICG) photothermal therapy (PTT) can be controlled. An (poly(acrylamide-co-diallyldimethylammonium chloride); PAD) that incorporates ICG as a near-infrared (NIR) absorber was fabricated using biocompatible...
Activity-guided isolation of a methanolic extract Galla Rhois using pancreatic lipase and 3T3-L1 adipocytes led to the seven phenolic compounds: protoaphin-fb (1), 2-O-digalloyl-1,3,4,6-tetra-O-galloyl-b-D-glucose (2), 1,2,3,4,6-penta-O-galloyl-b-D-glucose (3), 1,2,4,6-tetra-O-galloyl-b-D-glucose (4), 3-hydroxy-5-methoxy-phenol 1-O-b-D-glucoside (5), methylgallate (6), gallic acid (7). Their structures were established on basis NMR MS spectroscopic data interpretation. All isolates evaluated...
Background Advanced cancer therapy is targeted at primary tumors and also recurrent or metastatic cancers. Combinational treatment has recently shown high efficiency against In this study, we synthesized a thermal responsive hybrid nanoparticle (TRH) containing FimH, an immune stimulatory recombinant protein, for the induction of combination photothermal (PTT) immunotherapy its metastasis. Methods The was incorporated with near-infrared (NIR) absorbent, indocyanine green, decorated FimH on...
Abstract Rylene derivatives are known for their strong fluorescence, large absorption coefficients, and outstanding thermal photo‐stability. We report quantum‐mechanical (QM) calculations of various Lumogen® dyes encapsulated within core‐stabilized micelles. Theoretical methods were employed to calculate dyes' wavelengths, including time‐dependent density functional theory configuration interaction with implicit solvation models. Then, the calculated spectra compared experimental ones....
The surface charge of nanoparticles (NPs) is one the major physicochemical factors for their interactions in biological systems. To improve behavior NPs cellular environment, there are numerous efforts to evaluate effect on uptake NPs. In this study, we synthesized Pluronic block copolymer F127-based by modifying both ends with phosphate (PP) impart a negative and trimethylammonium bromide (AB) confer positive charge. By varying ratios PP-F127 AB-F127, produced range densities through...
본 연구는 눈개승마의 에탄올 추출물과 물 추출물의 항산화 및 주름개선 효과에 대하여 알아보고자 하였다. 실험결과, 폴리페놀 함량과 플라보노이드 함량은 추출물이 122 <TEX>${\mu}g/g$</TEX>, 36 <TEX>${\mu}g/g$</TEX>이고 87 26 <TEX>${\mu}g/g$</TEX>으로 나타났다. 눈개승마 DPPH 활성에 대한 <TEX>$RC_{50}$</TEX> 값은 각각 395 <TEX>${\mu}g$</TEX>와 4,682 <TEX>${\mu}g/mL$</TEX>이였고 ABTS 227 <TEX>${\mu}g/mL$</TEX>과 336 <TEX>${\mu}g/mL$</TEX>로 환원력은 2 mg/mL에서 1.58을 보였고 추출물에서는 0.88로 수렴효과는 10,000 <TEX>${\mu}g/mL$</TEX>에서 91.27, 16.35%로 또한 자외선을 조사하여 세포사멸을 유도한 실험에서 추출물을 100 <TEX>${\mu}g/mL$</TEX>의 농도로...