A5005037982- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Supramolecular Self-Assembly in Materials
- Retinal Development and Disorders
- Graphene and Nanomaterials Applications
- Polymer Surface Interaction Studies
- Osteoarthritis Treatment and Mechanisms
- Retinal Diseases and Treatments
- Nanocluster Synthesis and Applications
- Molecular Sensors and Ion Detection
- IoT-based Smart Home Systems
- Advanced Drug Delivery Systems
- Nanoparticles: synthesis and applications
- IPv6, Mobility, Handover, Networks, Security
- Polyamine Metabolism and Applications
- Lipid Membrane Structure and Behavior
- Distributed and Parallel Computing Systems
- Supramolecular Chemistry and Complexes
- Bladder and Urothelial Cancer Treatments
- Pickering emulsions and particle stabilization
- Proteoglycans and glycosaminoglycans research
Fusion Academy
2023
Fusion (United States)
2023
Korea Institute of Science and Technology
2023
Korea University
2023
Korean Association Of Science and Technology Studies
2023
Korea Institute of Fusion Energy
2023
Ulsan National Institute of Science and Technology
2017-2022
Government of the Republic of Korea
2018-2021
Johns Hopkins University
2015-2017
University of Massachusetts Amherst
2009-2016
Gold colloids functionalized with amino acids provide a scaffold for effective DNA binding subsequent condensation. Particles lysine and dendron functionality formed particularly compact complexes provided highly efficient gene delivery without any observed cytotoxicity. Nanoparticles first generation dendrons (NP−LysG1) were ∼28-fold superior to polylysine in reporter expression. These acid-based nanoparticles responsive intracellular glutathione levels, providing tool controlled release...
We have synthesized a highly efficient organic dye for dye-sensitized solar cell; the overall solar-to-energy conversion efficiency was 9.1% at AM 1.5 illumination (100 mW cm−2): short-circuit current density (Jsc) = 18.1 mA cm−2, open circuit photovoltage (Voc) 743 mV and fill factor (ff) 0.675.
Surface properties dictate the behavior of nanomaterials in vitro, vivo, and environment. Such include surface charge hydrophobicity. Also key are more complex supramolecular interactions such as aromatic stacking hydrogen bonding, even topology from structural to atomic level. functionalization nanoparticles (NPs) provides an effective way control interface between biological systems they designed interact with. In medicine, for instance, proper can maximize therapeutic or imaging efficacy...
Abstract Targeted drug delivery using nanoparticles can minimize the side effects of conventional pharmaceutical agents and enhance their efficacy. However, translating nanoparticle-based into clinical applications still remains a challenge due to difficulty in regulating interactions on interfaces between biological systems. Here, we present targeting strategy for incorporated with supramolecularly pre-coated recombinant fusion protein which HER2-binding affibody combines glutathione- S...
This paper describes a home energy management system (HEMS) based on power line communication. Smart metering and communication can provide detailed information of consumption patterns intelligent controlling to appliances at home. We propose HEMS that easy-to-access in real time, planning for appliances, optimization The consists three modules: an advanced control engine, device module, resource server. Our prototype reduces the cost by about 10%.
Achieving spatiotemporal control of molecular self-assembly associated with actuation biological functions inside living cells remains a challenge owing to the complexity cellular environments and lack characterization tools. We present, for first time, organelle-localized peptide amphiphile as powerful strategy controlling fate. A phenylalanine dipeptide (FF) mitochondria-targeting moiety, triphenyl phosphonium (Mito-FF), preferentially accumulates mitochondria reaches critical aggregation...
Intracellular protein delivery is an important tool for both therapeutic and fundamental applications. Effective faces two major challenges: efficient cellular uptake avoiding endosomal sequestration. We report here a general strategy direct of functional proteins to the cytosol using nanoparticle-stabilized capsules (NPSCs). These NPSCs are formed stabilized through supramolecular interactions between nanoparticle, cargo, fatty acid capsule interior. The ~130 nm in diameter feature low...
Abstract Nanomedicines exploit the unusual physicochemical and biological properties of nanoparticles, including their nanoscopic size, high surface‐area‐to‐volume ratio, easy surface modification, biocompatibility. Among various therapeutic diagnostic applications nanomedicines, cancer‐targeted drug delivery systems (DDS) have been found to be a promising area research. Effective DDS rely on two major factors: slow sustained release chemotherapeutic drugs targeted tumor sites. Both...
Senolytics, which eliminate senescent cells from tissues, represent an emerging therapeutic strategy for various age-related diseases. Most senolytics target antiapoptotic proteins, are overexpressed in cells, limiting specificity and inducing severe side effects. To overcome these limitations, we constructed self-assembling targeting with intracellular oligomerization system. Intracellular aryl-dithiol-containing peptide occurred only inside the mitochondria of due to selective localization...
Recent advances in supramolecular chemistry research have led to the development of artificial chemical systems that can form self-assembled structures imitate proteins involved regulation cellular function. However, intracellular polymerization operate inside living cells been seldom reported. In this study, we developed an intramitochondrial polymerization-induced self-assembly system for regulating fate cancer cells. It showed polymeric disulfide formation occurred due high reactive...
Systemic administration of mesoporous silica nanoparticles (MSNs) in biomedical applications has recently been questioned because poor degradability, which is necessary for the successful development new drug-delivery systems. Herein, we report colloidal-state-degradable MSNs functionalized with versatile polymer-gatekeepers a cancer-cell-targeted moiety. The polymer (PMSNs) were designed disulfide cross-linking enabling safe encapsulation until cargos are delivered to target cancer cells....
Mitochondria targeting mineralization can form biominerals inside cancerous mitochondria through concentration dependent silicification, resulting in dysfunction of leading to apoptosis. These results suggest potential therapeutics for cancer treatment.
Abstract Combination chemotherapy has become the primary strategy against cancer multidrug resistance; however, accomplishing optimal pharmacokinetic delivery of multiple drugs is still challenging. Herein, we report a sequential combination drug exploiting pH-triggerable and redox switch to release cargos from hollow silica nanoparticles in spatiotemporal manner. This versatile system further enables large loading efficiency for both hydrophobic hydrophilic inside nanoparticles, followed by...
Prolonged retention of internalized nanoparticulate systems inside cells improves their efficacy in imaging, drug delivery, and theranostic applications. Especially, regulating exocytosis the nanoparticles is a key factor fabrication effective nanocarriers for chemotherapeutic treatments but orthogonal control cellular environment major challenge. Herein, we present first example gold (AuNPs), model carrier, by using simple host-guest supramolecular system. AuNPs featuring quaternary amine...
Getting out is just as important for nanotherapeutics getting in. Exocytosis rates determine residency time in the cell, an determinant therapeutic efficacy and also eventual clearance from cell. In this study, it shown that exocytosis efficiency determined by surface functionality, providing a strategy optimizing nanocarriers. As service to our authors readers, journal provides supporting information supplied authors. Such materials are peer reviewed may be re-organized online delivery,...
A dendrimer–nanoparticle hybrid scaffold based on robust dithiocarbamate formation provides a controlled drug delivery system. These composite films are non-toxic and can incorporate variety of guests, providing sustained release over multiple uses. The system is highly modular: the process be easily tuned by altering dendrimer generation size AuNPs, generating versatile Detailed facts importance to specialist readers published as "Supporting Information". Such documents peer-reviewed, but...
Current drug delivery systems are hampered by poor to tumors, in part reflecting encapsulation stability of nanocarriers. Although nanocarriers such as polymeric micelles have high colloidal and do not aggregate or precipitate bulk solution, with low can lose their cargo during circulation blood due interactions cells, cellular membranes, serum proteins, other biomacromolecules. The resulting premature release from carriers limits the therapeutic efficacy at target sites. Herein, we report a...