A5026400127- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Obstructive Sleep Apnea Research
- Sleep and related disorders
- High Altitude and Hypoxia
- Infective Endocarditis Diagnosis and Management
- Antibiotic Resistance in Bacteria
- Streptococcal Infections and Treatments
- Regulation of Appetite and Obesity
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Antibiotic Use and Resistance
- Heme Oxygenase-1 and Carbon Monoxide
- Hemoglobin structure and function
- Circadian rhythm and melatonin
- Nerve injury and regeneration
- Stress Responses and Cortisol
University of Chicago
2010-2018
Atlantic Health System
2018
Biomedical Research Institute
2018
Vardhman Mahavir Medical College & Safdarjung Hospital
2007-2016
National Institute of Mental Health and Neurosciences
2006
Although neurotrophins have been postulated to antidepressant properties, their effect on anxiety is not clear. We find that transgenic overexpression of the neurotrophin BDNF has an unexpected facilitatory anxiety-like behavior, concomitant with increased spinogenesis in basolateral amygdala. Moreover, anxiogenesis and amygdalar are also triggered by chronic stress control mice but occluded overexpression, thereby suggesting a role for signaling stress-induced plasticity causes effects,...
Sleep fragmentation (SF) is one of the major characteristics sleep apnea, and has been implicated in its morbid consequences, which encompass excessive daytime sleepiness neurocognitive impairments. We hypothesized that absence nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity neuroprotective SF-induced cognitive impairments.To examine whether increased NADPH may play a role central nervous system dysfunction.The effect chronic SF during sleep-predominant period on...
In rodents, exposure to intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), is associated with neurobehavioral impairments, increased apoptosis in the hippocampus and cortex, as well oxidant stress inflammation. Excessive NADPH oxidase activity may play role IH-induced CNS dysfunction.The effect IH during light period on two forms spatial learning water maze markers oxidative was assessed mice lacking (gp91phox(_/Y)) wild-type littermates. On standard place training task,...
Sleepiness and cognitive dysfunction are recognized as prominent consequences of sleep deprivation. Experimentally induced short-term fragmentation, even in the absence any reductions total duration, will lead to emergence excessive daytime sleepiness impairments humans. Tumor necrosis factor (TNF)-α has important regulatory effects on sleep, seems play a role occurrence children who have disrupted result obstructive apnea, condition associated with fragmentation. The aim this study was...
Short sleep confers a higher risk of obesity in humans. Restricted increases appetite, promotes calorie intake from fat and carbohydrate sources, induces insulin resistance. However, the effects fragmented (SF), such as occurs apnea, on body weight, metabolic rates, adipose tissue distribution are unknown.C57BL/6 mice were exposed to SF for 8 weeks. Their food consumption, expenditure monitored over time, their plasma leptin levels measured after exposure 1 day well 2 In addition, was...
Exposure to intermittent hypoxia (IH), such as occurs in sleep-disordered breathing, is associated with substantial cognitive impairments, oxidative stress and inflammation, increased neuronal cell losses brain regions underlying learning memory rats. Physical activity (PA) now recognized neuroprotective models of injury degeneration.To examine whether PA will ameliorate IH-induced deficits.Young adult Sprague-Dawley rats were randomly assigned one four treatment groups including normal (NA)...
Decreased susceptibility of Neisseria meningitidis isolates to ciprofloxacin emerged from an outbreak in Delhi, India. Results antimicrobial testing the meningococcal and further sequencing DNA gyrase A quinolone-resistance-determining region confirmed emergence resistance outbreak.
Abstract Intermittent hypoxia ( IH ) during sleep, such as occurs in obstructive sleep apnea OSA ), leads to degenerative changes the hippocampus, and is associated with spatial learning deficits adult mice. In both patients murine models of , disease suppression growth hormone GH secretion, which actively involved growth, development, function central nervous system CNS ). Recent work showed that exogenous therapy attenuated neurocognitive elicited by rats. Here, we show administration...
The first of several cases meningococcal meningitis was reported in April 2005, New Delhi, India. Subsequent to this the Government declared an outbreak, which persisted for two periods, from April-July 2005 and January-March 2006. National Institute Communicable Diseases (NICD) recommended using WHO criteria diagnosis disease. During outbreak 380 clinically suspected were investigated. Of 55 diagnosed as confirmed/probable mortality rate 14.6%. Meningitis 60% meningococcaemia 40%....
Background: Obstructive sleep apnea (OSA) is a highly prevalent disease manifesting as intermittent hypoxia during (IH) and increasingly recognized being independently associated with neurobehavioral deficits. These deficits may be due to increased apoptosis in the hippocampus cerebral cortex, well oxidative stress inflammation. It has been reported that neuroglobin (Ngb) upregulated response hypoxia-ischemia insults exhibits protective role ischemia-reperfusion brain injury. We hypothesized...
Abstract Decreased susceptibility of Neisseria meningitidis isolates to ciprofloxacin emerged from an outbreak in Delhi, India. Results antimicrobial testing the meningococcal and further sequencing DNA gyrase A quinolone-resistance–determining region confirmed emergence resistance outbreak.