A5111913022- Obstructive Sleep Apnea Research
- Adipose Tissue and Metabolism
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Gut microbiota and health
- Birth, Development, and Health
- Metabolomics and Mass Spectrometry Studies
- Tracheal and airway disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Sleep and related disorders
- Mesenchymal stem cell research
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Gestational Diabetes Research and Management
- RNA regulation and disease
- Cancer, Hypoxia, and Metabolism
- Circadian rhythm and melatonin
- Immune cells in cancer
- Tryptophan and brain disorders
- Advanced Chemical Sensor Technologies
- Genetic and phenotypic traits in livestock
Sahlgrenska University Hospital
2018-2025
University of Gothenburg
2018-2025
AstraZeneca (Sweden)
2016-2019
University of Chicago
2012-2016
Comer Children's Hospital
2012-2015
SleepMed
2015
University of Louisville
2014
Universitat de Barcelona
2007-2012
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2007-2011
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2011
Abstract Chronic sleep fragmentation (SF) commonly occurs in human populations, and although it does not involve circadian shifts or deprivation, markedly alters feeding behaviors ultimately promoting obesity insulin resistance. These symptoms are known to be related the host gut microbiota. Mice were exposed SF for 4 weeks then allowed recover 2 weeks. Taxonomic profiles of fecal microbiota obtained prospectively, conventionalization experiments performed germ-free mice. Adipose tissue...
An increased cancer aggressiveness and mortality have been recently reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), a hallmark of OSA, enhances melanoma growth metastasis in mice.
Abstract Sleep fragmentation (SF) is a highly prevalent condition and hallmark of sleep apnea, that has been associated with increased cancer incidence mortality. In this study, we examined the hypothesis promotes tumor growth progression through proinflammatory TLR4 signaling. design, compared mice were exposed to one week before engraftment syngeneic TC1 or LL3 cells analysis four weeks later. We also host contributions use genetically deficient in its effector molecules MYD88 TRIF. found...
Sleep fragmentation (SF) is a common occurrence and constitutes major characteristic of obstructive sleep apnea (OSA). SF has been implicated in multiple OSA-related morbidities, but it unclear whether underlies any the cardiovascular morbidities OSA. We hypothesized that long-term exposures may lead to endothelial dysfunction altered vessel wall structure. Adult male C57BL/6J mice were fed normal chow exposed daylight or control (CTL) for 20 weeks. Telemetric blood pressure function...
Sleepiness and cognitive dysfunction are recognized as prominent consequences of sleep deprivation. Experimentally induced short-term fragmentation, even in the absence any reductions total duration, will lead to emergence excessive daytime sleepiness impairments humans. Tumor necrosis factor (TNF)-α has important regulatory effects on sleep, seems play a role occurrence children who have disrupted result obstructive apnea, condition associated with fragmentation. The aim this study was...
Obstructive sleep apnea (OSA) has been linked to obesity, inflammation, and metabolic syndrome. The gut microbiota, which serves as reservoir for bacterial lipopolysaccharides (LPS), could be altered by OSA trigger inflammation. LPS-binding protein (LBP) a surrogate marker of underlying low-grade endotoxemia LPS from the gut. We hypothesized that systemic LBP levels would higher in obese children those with OSA. Consecutive snoring nonsnoring (mean age 6.8 ± 1.3 y) were included after...
Plasma concentration of low-density lipoprotein (LDL) cholesterol is a well-established risk factor for cardiovascular disease. Inhibition proprotein convertase subtilisin/kexin type 9 (PCSK9), which regulates homeostasis, has recently emerged as an approach to reduce levels. The development humanized animal models important step validate and study human drug targets, use genome base editing been proposed mean target disease alleles. To address the lack validated test safety efficacy...
GFRAL-expressing neurons actuate aversion and nausea, are targets for obesity treatment, may mediate metformin effects by long-term GDF15-GFRAL agonism. Whether GFRAL+ acutely regulate glucose energy homeostasis is, however, underexplored. Here, we report that cell-specific activation of using a variety techniques causes torpor-like state, including hypothermia, the release stress hormones, shift from to lipid oxidation, impaired insulin sensitivity, tolerance, skeletal muscle uptake but...
Short sleep confers a higher risk of obesity in humans. Restricted increases appetite, promotes calorie intake from fat and carbohydrate sources, induces insulin resistance. However, the effects fragmented (SF), such as occurs apnea, on body weight, metabolic rates, adipose tissue distribution are unknown.C57BL/6 mice were exposed to SF for 8 weeks. Their food consumption, expenditure monitored over time, their plasma leptin levels measured after exposure 1 day well 2 In addition, was...
Sleep fragmentation (SF) is highly prevalent and may constitute an important contributing factor to excessive weight gain the metabolic syndrome. Increased endoplasmic reticulum (ER) stress activation of unfolded protein response (UPR) leading attenuation leptin receptor signaling in hypothalamus leads obesity dysfunction.Mice were exposed SF sleep control (SC) for varying periods time during which ingestive behaviors monitored. UPR pathways assessed hypothalami. To further examine...
Intermittent hypoxia (IH) is a frequent occurrence in sleep and respiratory disorders. Both human murine studies show that IH may be implicated metabolic dysfunction. Although the effects of nocturnal low-frequency intermittent (IH(L)) have not been extensively examined, it would appear IH(L) high-frequency (IH(H)) elicit distinct adaptations. To this effect, C57BL/6J mice were randomly assigned to IH(H) (cycles 90 s 6.4% O(2) 21% during daylight), (8% daylight hours), or control (CTL) for 5...
Chronic intermittent hypoxia during sleep (IH), as occurs in apnea, promotes systemic insulin resistance. Resveratrol (Resv) has been reported to ameliorate high-fat diet-induced obesity, inflammation, and To examine the effect of Resv on IH-induced metabolic dysfunction, male mice were subjected IH or room air conditions for 8 weeks treated with either vehicle (Veh). Fasting plasma levels glucose, insulin, leptin obtained, homeostatic model assessment resistance index calculated,...
Sleep fragmentation (SF) is a common condition among pregnant women, particularly during late gestation. Gestational perturbations promote the emergence of adiposity and metabolic disease risk in offspring, most likely through epigenetic modifications. Adiponectin (AdipoQ) expression inversely correlates with obesity insulin resistance. The effects SF gestation on function AdipoQ visceral white adipose tissue (VWAT) offspring mice are unknown. Male were assessed at 24 weeks after dams...
Activation of brown adipose tissue (BAT) and browning white (WAT) present potential new therapies for obesity type 2 diabetes. Here, we examined the effects β3-adrenergic stimulation on tissue-specific uptake storage free fatty acids (FFA) its implications whole body FFA metabolism in diet-induced obese rats using a multi-radiotracer technique. Male Wistar were high fat-fed 12 wk administered β3-agonist CL316,243 (CL, 1 mg·kg-1·day-1) or saline via osmotic minipumps during last 3 wk. The...
The upper airway of obstructive sleep apnoea patients is subjected to recurrent negative pressure swings promoting its collapse and reopening. aim the present study was ascertain whether this mechanical stress induces inflammation in a rat model. Sprague–Dawley rats periodic pattern (-40 cmH 2 O, 1 s) positive (4 pressures inducing reopening for 5 h. Rats that were instrumented but not used as controls. gene expression pro-inflammatory biomarkers macrophage inflammatory protein (MIP)-2,...
To investigate whether noninvasive application of recurrent airway obstructions induces early release mesenchymal stem cells into the circulating blood in a rat model obstructive sleep apnea.Prospective controlled animal study.University laboratory.Twenty male Sprague-Dawley rats (250-300 g).A specially designed nasal mask was applied to anesthetized rats. Ten were subjected pattern apneas (60 per hour, lasting 15 seconds each) for 5 hours. used as controls.Mesenchymal from and bone marrow...
BACKGROUND: The microbially produced amino acid–derived metabolite imidazole propionate (ImP) contributes to the pathogenesis of type 2 diabetes. However, effects ImP on endothelial cell (EC) physiology and its role in atherosclerotic coronary artery disease are unknown. Using both human animal model studies, we investigated potential contributory development atherosclerosis. METHODS: Plasma levels were measured patients undergoing elective cardiac angiography (n=831) by ultra-high...
Excessive sleep fragmentation (SF) is common in pregnant women. Adult-onset metabolic disorders may begin during early development and exhibit substantial sex dimorphism. We hypothesized that dysfunction induced by gestational SF male mice would not be apparent female littermates. Body weight food consumption were measured weekly offspring after late or control (SC). At 20 weeks, plasma leptin, adiponectin, lipid profiles, insulin glucose tolerance tests assessed. Leptin M1, M2 macrophage...